51093-55-1

• 常用中文名：Roseoflavin
• 常用英文名：Roseoflavin
• CAS号：51093-55-1
• 分子式：C₁₈H₂₃N₅O₆
• 分子量：404.417
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2016-12-05 06:21:10
• 更新时间：2024-01-02 19:19:35
• Roseoflavin 是一种天然色素,最初从 Streptomyces davawensis 中分离出来,是核黄素和黄素单核苷酸的抗代谢类似物,具有抗菌作用。

名称

• 中文名: 玫瑰黄色素
• 英文名: roseoflavin
• 英文别名: Roseoflavine; Riboflavin,8-demethyl-8-(dimethylamino); C18H23N5O6; 8-Dimethylaminoriboflavin; D-Ribitol, 1-deoxy-1-[8-(dimethylamino)-3,4-dihydro-7-methyl-2,4-dioxopyrimido[4,5-b]quinolin-10(2H)-yl]-; 8-(dimethylamino)-7-methyl-10-(2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4-dione; 7-Methyl-8-dimethylamino-10-(1'-D-ribityl)isoalloxazin; 8-(dimethylamino)-7-methyl-10-((2S,3S,4R)-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione; 8-demethyl-8-(dimethylamino)riboflavin; 8-dimethylamino-7-methyl-10-D-ribitol-1-yl-10H-benzo[g]pteridine-2,4-dione; 1-Deoxy-1-[8-(dimethylamino)-7-methyl-2,4-dioxo-3,4-dihydropyrimido[4,5-b]quinolin-10(2H)-yl]-D-ribitol; Roseoflavin

物化性质

• 密度: 1.5±0.1 g/cm3
• 熔点: 276-278ºC
• 分子式: C₁₈H₂₃N₅O₆
• 分子量: 404.417
• 精确质量: 404.169586
• PSA: 151.91000
• LogP: -0.55
• 折射率: 1.688
• 储存条件: -20°C

生物活性

• 描述: Roseoflavin 是一种天然色素,最初从 Streptomyces davawensis 中分离出来,是核黄素和黄素单核苷酸的抗代谢类似物,具有抗菌作用。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 体外研究: 玫瑰黄酮是黄素单核苷酸(FMN)和核黄素的化学类似物,具有抗菌活性,可直接与FMN核糖开关(Kd～100nm)适体结合,下调枯草芽孢杆菌FMN核糖开关lacZ报告基因的表达[1]。
• 参考文献:

  [1]. Lee ER, et al. Roseoflavin is a natural antibacterial compound that binds to FMN riboswitches and regulates gene expression. RNA Biol. 2009;6(2):187-194.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VJ1300000 CHEMICAL NAME : Riboflavin, 8-demethyl-8-(dimethylamino)- CAS REGISTRY NUMBER : 51093-55-1 LAST UPDATED : 199309 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C18-H23-N5-O6 MOLECULAR WEIGHT : 405.46 WISWESSER LINE NOTATION : T C666 BN DNVMV INJ B1YQYQYQ1Q L1 MN1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,277,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 27,88,1974