毒理学数据:
LD50:9000 mg/kg(大鼠经口).锰可造成中枢神经系统严重病变,严重者可出现帕金森氏症。对大脑纹状体苍白球部位能造成严重破坏,对肝、肾及心肌出现变性改变。
生态学数据:
水中浓度 0.1mg/L时,使BOD5降低。水中嗅觉阈浓度: 其浓度 0.5mg/L时,水有金属味。
CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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OO9275000
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CHEMICAL NAME :
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Manganese
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CAS REGISTRY NUMBER :
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7439-96-5
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LAST UPDATED :
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199712
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DATA ITEMS CITED :
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52
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MOLECULAR FORMULA :
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Mn
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MOLECULAR WEIGHT :
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54.94
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WISWESSER LINE NOTATION :
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MN
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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REFERENCE :
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28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,21,1972
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
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Rodent - rabbit
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REFERENCE :
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28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,21,1972 ** ACUTE TOXICITY DATA **
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Human - man
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DOSE/DURATION :
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2300 ug/m3
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TOXIC EFFECTS :
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Brain and Coverings - other degenerative changes Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness
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REFERENCE :
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AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 27,454,1966
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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9 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,21,1972 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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180 mg/kg/30D-I
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TOXIC EFFECTS :
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Brain and Coverings - other degenerative changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - changes in metals, not otherwise specified
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REFERENCE :
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TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 7,217,1981 ** TUMORIGENIC DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intramuscular
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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400 mg/kg/1Y-I
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REFERENCE :
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NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the National Cancer Institute by The Institute of Chemical Biology, University of San Francisco. (San Francisco, CA 94117) Volume(issue)/page/year: PH43-64-886 *** REVIEWS *** ACGIH TLV-TWA 0.2(Mn)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW TRBMAV Texas Reports on Biology and Medicine. (Galveston, TX) V.1-41(2), 1943-81/82. Discontinued. Volume(issue)/page/year: 33,85,1975 TOXICOLOGY REVIEW ACLSCP Annals of Clinical and Laboratory Science. (1833 Delancey Pl., Philadelphia, PA 19103) V.1- 1971- Volume(issue)/page/year: 4,487,1974 TOXICOLOGY REVIEW ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued. Volume(issue)/page/year: 5,51,1972 TOXICOLOGY REVIEW FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ. Volume(issue)/page/year: 7,313,1942 TOXICOLOGY REVIEW KOTTAM Kogai to Taisaku. Journal of Environmental Pollution Control. (Kogai Taisaku Gijutsu Dokokai, Shuwa-Akasaka Bldg., 9-1-244, Akasaka, Minato-ku, Tokyo 107, Japan) V.1- 1965- Volume(issue)/page/year: 11,1300,1975 TOXICOLOGY REVIEW 85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77 Volume(issue)/page/year: Mn,1,1973 TOXICOLOGY REVIEW PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1960- Volume(issue)/page/year: 12,102,1969 TOXICOLOGY REVIEW IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5. Volume(issue)/page/year: 24,1,1955 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD:air-CL 5 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,149,1971 OSHA PEL (Gen Indu):CL 5 mg(Mn)/m3, fume CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):CL 5 mg(Mn)/m3, fume CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):CL 5 mg(Mn)/m3, fume CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):CL 5 mg(Mn)/m3, fume CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 5 mg/m3 JAN 1993 OEL-AUSTRALIA:TWA 1 mg/m3;STEL 3 mg/m3 (fume) JAN 1993 OEL-BELGIUM:TWA 1 mg/m3;STEL 3 mg/m3 (fume) JAN 1993 OEL-DENMARK:TWA 1 mg/m3 (fume) JAN 1993 OEL-DENMARK:TWA 2.5 mg/m3 JAN 1993 OEL-FINLAND:TWA 1 mg/m3 (fume) JAN 1993 OEL-FINLAND:TWA 2.5 mg/m3 JAN 1993 OEL-FRANCE:TWA 1 mg/m3 (fume) JAN 1993 OEL-GERMANY:TWA 5 mg/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 5 mg/m3 JAN 1993 OEL-RUSSIA:STEL 0.2 mg/m3 (fume) JAN 1993 OEL-SWEDEN:TWA 2.5 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 1 mg/m3 (fume) JAN 1993 OEL-SWITZERLAND:TWA 5 mg/m3 JAN 1993 OEL-THAILAND:TWA 5 mg/m3 JAN 1993 OEL-TURKEY:TWA 5 mg/m3 (fume) JAN 1993 OEL-UNITED KINGDOM:TWA 1 mg/m3;STEL 3 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO MANGANESE COMPDS (as Mn)-air:TWA 1 mg/m3;STEL 3 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 44000 No. of Facilities: 1963 (estimated) No. of Industries: 29 No. of Occupations: 53 No. of Employees: 19787 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5920 No. of Facilities: 26 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 305 (estimated) No. of Female Employees: 71 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5992 No. of Facilities: 235 (estimated) No. of Industries: 9 No. of Occupations: 9 No. of Employees: 4560 (estimated) No. of Female Employees: 12 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 44000 No. of Facilities: 66404 (estimated) No. of Industries: 316 No. of Occupations: 125 No. of Employees: 756403 (estimated) No. of Female Employees: 15912 (estimated)
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