66-05-7

• 常用中文名：PHENIPRAZINE HYDROCHLORIDE
• 常用英文名：PHENIPRAZINE HYDROCHLORIDE
• CAS号：66-05-7
• 分子式：C₉H₁₅ClN₂
• 分子量：186.68200
• 相关类别： 信号通路 神经信号通路 单胺氧化酶
• 发布时间：2016-08-24 15:45:53
• 更新时间：2024-01-14 22:11:21
• 盐酸苯哌嗪是一种强效、长效的单胺氧化酶抑制剂。哌嗪具有研究抑郁症的潜力[1]。

名称

• 英文名: 1-phenylpropan-2-ylhydrazine,hydrochloride

物化性质

• 分子式: C₉H₁₅ClN₂
• 分子量: 186.68200
• 精确质量: 186.09200
• PSA: 38.05000
• LogP: 2.97410

生物活性

• 描述: 盐酸苯哌嗪是一种强效、长效的单胺氧化酶抑制剂。哌嗪具有研究抑郁症的潜力[1]。
• 相关类别:
  信号通路 >> 神经信号通路 >> 单胺氧化酶
  研究领域 >> 神经疾病
• 参考文献:

  [1]. HORITA A. beta-Phenylisopropylhydrazine, a potent and long acting monoamine oxidase inhibitor. J Pharmacol Exp Ther.

  [2]. Stein, Larry, et al. Accelerated recovery from reserpine depression by monoamine oxidase inhibitors.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : MV7400000 CHEMICAL NAME : Hydrazine, (alpha-methylphenethyl)-, monohydrochloride CAS REGISTRY NUMBER : 66-05-7 LAST UPDATED : 199206 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C9-H14-N2.Cl-H MOLECULAR WEIGHT : 186.71 WISWESSER LINE NOTATION : ZM1Y1&R &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 180 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 18,617,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 59 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IJNEAQ International Journal of Neuropharmacology. (New York, NY) V.1-8, 1962-69. For publisher information, see NEPHBW. Volume(issue)/page/year: 5,125,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 112 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,20,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 87 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IJNEAQ International Journal of Neuropharmacology. (New York, NY) V.1-8, 1962-69. For publisher information, see NEPHBW. Volume(issue)/page/year: 5,125,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 66 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IJNEAQ International Journal of Neuropharmacology. (New York, NY) V.1-8, 1962-69. For publisher information, see NEPHBW. Volume(issue)/page/year: 5,125,1966