851443-04-4

• 常用中文名：瑞舒伐他汀乙酯
• 常用英文名：Rosuvastatin ethyl ester
• CAS号：851443-04-4
• 分子式：C₂₄H₃₂FN₃O₆S
• 分子量：509.591
• 发布时间：2018-09-10 07:26:19
• 更新时间：2026-07-03 12:17:48

名称

• 中文名: 瑞舒伐他汀乙酯
• 英文名: (3R,5S,E)-Ethyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido) pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate
• 中文别名: 7-[4-(4-氟苯基)-6-异丙基-2-(N-甲基-N-甲磺酰氨基)嘧啶-5-基]-3,5－二羟基-6(E)-庚烯酸乙酯; 罗苏伐他汀乙酯; (3R,5S,E)-7-(4-(4-氟苯基)-6-异丙基-2-(N-甲基甲磺酰胺基)嘧啶-5-基)-3,5-二羟基庚-6-烯酸乙酯; (3R,5S,E)-乙基7-(4-(4-氟苯基)-6-异丙基-2-(N-甲基甲基磺酰胺基)嘧啶-5-基)-3,5-二羟基庚基6-烯酸酯(瑞舒伐他汀杂质); 瑞舒伐他汀杂质13; 瑞舒伐他汀对接光降解-1; 瑞舒伐他汀乙酯(杂质5); 瑞舒伐他汀FP杂质A; 瑞舒伐他汀酸乙酯; 罗苏伐他汀FP杂质A; 舒伐他汀乙酯; 超级他汀乙酯
• 英文别名: ROSUVASTATIN FP IMPURITY A (ROSUVASTATIN ETHYL ESTER); 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-(N-methyl-N-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-ht-6-enoic acid ethyl ester; 6-Htenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, ethyl ester, (3R,5S,6E); ethyl (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate; Rosuvastatin Impurity 23; Ethyl (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoate; Ethyl (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl}-3,5-dihydroxy-6-heptenoate; (3R,5S,E)-Ethyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl); Rosuvastatin Impurity 5; (E)-(+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(methansulfonyl-methylamino)-pyrimidin-5-yl]-(3R,5S)-dihydroxy-hept-6-enoate ethyl ester; ethyl (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate; ROSUVASTATIN ETHYL ESTER; (3R,5S,E)-Ethyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido) pyrimidin-5-yl)-3; Ethyl (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-htenoate; (3R,5S,E)-Ethyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido) pyrimidin-5-yl)-3,5-dihydroxyht-6-enoate; 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-(N-methyl-N-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid ethyl ester; Ethyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyht-6-enoate; ROSUVASTATIN ETHYL ESTHER; (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)]-2-[methyl(methylsulfonyl)amino-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid ethyl ester; (+)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl)-(3R,5S,6E)-dihydroxy-hept-6-enoic acid ethyl ester; 7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-ht-6-enoic acid ethyl ester; (3R,5S,E)-ethyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyht-6-enoate (Rosuvastatin Impurity）; Rosuvastatin ethyl ester Impurity; (+)-ethyl 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxy-6(E)-heptenoate; (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid ethyl ester; Rosuvastatin Acid Ethyl Ester; 3-Isoxazolecboxylicacid,5-(3-furanyl); Rosuvastatine; Rosuvastatin Ethyl Ester; Rosuvastatin FP Impurity A

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 699.1±65.0 °C at 760 mmHg
• 分子式: C₂₄H₃₂FN₃O₆S
• 分子量: 509.591
• 闪点: 376.6±34.3 °C
• 精确质量: 509.199585
• PSA: 138.30000
• LogP: 1.54
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.571

安全

• 海关编码: 2942000000

合成路线

901765-36-4 ~99% 851443-04-4

文献：AUROBINDO PHARMA LIMITED Patent: WO2008/96257 A1, 2008 ; Location in patent: Page/Page column 24 ;

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