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303-54-8

303-54-8结构式

常用中文名：地帕明
常用英文名：Depramine
CAS号：303-54-8
分子式：C₁₉H₂₂N₂
分子量：278.39
相关类别：信号通路神经信号通路疼痛
发布时间：2018-07-23 17:57:07
更新时间：2024-01-12 13:00:28
Depramine(GP 31406)是一种具有药理活性的三环类抗抑郁药。Depramine抑制乙酰胆碱酯酶、Mg2+-ATP酶和Na+/K+ATP酶活性[1][2]。

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中文名	地帕明
英文名	3-benzo[b][1]benzazepin-11-yl-N,N-dimethylpropan-1-amine
英文别名	(3-dibenzo[b,f]azepin-5-yl-propyl)-dimethyl-amine Depramine Depramina [INN-Spanish] 5-(3-(Dimethylamino)propyl)-5H-dibenz(b,f)azepine 10,11-Dehydroimipramine 5H-Dibenz(b,f)azepine,5-(3-(dimethylamino)propyl) Depraminum [INN-Latin] 5-(8-Dimethylaminopropyl)-iminostilben Balipramine 5-(3'-Dimethyl-amino-propyl)-5H-dibenz<b,f>azepin

描述	Depramine(GP 31406)是一种具有药理活性的三环类抗抑郁药。Depramine抑制乙酰胆碱酯酶、Mg2+-ATP酶和Na+/K+ATP酶活性[1][2]。
相关类别	研究领域 >> 神经疾病信号通路 >> 神经信号通路 >> 疼痛
靶点	Acetylcholinesterase (AChE), Mg2+-ATPase, Na+/K+ ATPase[1]
参考文献	[1]. Caratsch CG, et al. Tricyclic antidepressants: action on synaptosomal acetylcholinesterase and ATPase in the brain of guinea pigs and subcellular distribution. Neuropharmacology. 1973 Jun;12(6):563-75.

密度	1.06g/cm3
沸点	413.9ºC at 760mmHg
分子式	C₁₉H₂₂N₂
分子量	278.39
闪点	185.9ºC
精确质量	278.17800
PSA	6.48000
LogP	4.32520
折射率	1.589

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HO1480000

CHEMICAL NAME :: 5H-Dibenz(b,f)azepine, 5-(3-(dimethylamino)propyl)-

CAS REGISTRY NUMBER :: 303-54-8

BEILSTEIN REFERENCE NO. :: 1319717

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C19-H22-N2

MOLECULAR WEIGHT :: 278.43

WISWESSER LINE NOTATION :: T C676 BNJ B3N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 23 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 120,450,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 41 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 120,450,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 6 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 120,450,1959

海关编码	2933990090

256-96-2结构式

256-96-2

109-54-6结构式

109-54-6

~%

303-54-8结构式

303-54-8

文献：Schmolka; Zimmer Synthesis, 1984 , vol. NO. 1, p. 29 - 31

上游产品 2
256-96-2 109-54-6
下游产品 0

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%