15302-10-0

• 常用中文名：氯丁卡因
• 常用英文名：Clibucaine
• CAS号：15302-10-0
• 分子式：C₁₅H₂₀Cl₂N₂O
• 分子量：315.24
• 相关类别： 研究领域 其他
• 发布时间：2018-03-06 08:00:00
• 更新时间：2024-01-23 19:11:49
• 克利布卡因是一种哌啶衍生物,具有局部麻醉特性。克利布卡因可用作局部麻醉剂[1]。

名称

• 中文名: 氯丁卡因
• 英文名: N-(2,4-dichlorophenyl)-3-piperidin-1-ylbutanamide
• 英文别名: Clibucaina; 3-Piperidino-buttersaeure-(2,4-dichlor-anilid); Clibucaine; Clibucaina [INN-Spanish]; 3-piperidino-butyric acid-(2,4-dichloro-anilide); Clibucainum [INN-Latin]

物化性质

• 密度: 1.255g/cm3
• 沸点: 466.8ºC at 760mmHg
• 分子式: C₁₅H₂₀Cl₂N₂O
• 分子量: 315.24
• 闪点: 236.1ºC
• 精确质量: 314.09500
• PSA: 35.83000
• LogP: 4.78380
• 蒸汽压: 6.86E-09mmHg at 25°C
• 折射率: 1.585
• 储存条件: 室温

生物活性

• 描述: 克利布卡因是一种哌啶衍生物,具有局部麻醉特性。克利布卡因可用作局部麻醉剂[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Dennie Van Den Heuvel, et al. Gastro-retentive oral dosage unit containing a local anaesthetic. Patent, WO2023094100A1.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TN3712310 CHEMICAL NAME : 1-Piperidinepropionanilide, 2',4'-dichloro-beta-methyl- CAS REGISTRY NUMBER : 15302-10-0 BEILSTEIN REFERENCE NO. : 0249881 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C15-H20-Cl2-N2-O MOLECULAR WEIGHT : 315.27 WISWESSER LINE NOTATION : T6NTJ AY1&1VMR BG DG HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 38,1085,1955 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 220 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 38,1085,1955 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 59 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 38,1085,1955

安全

• 海关编码: 2933399090

合成路线

554-00-7 ~% 15302-10-0

文献：Wilder Smith; Hofstetter Helvetica Chimica Acta, 1955 , vol. 38, p. 1085,1089,1091

110-89-4 99057-78-0 ~% 15302-10-0

文献：Wilder Smith; Hofstetter Helvetica Chimica Acta, 1955 , vol. 38, p. 1085,1089,1091

110-89-4 ~% 15302-10-0

文献：Wilder Smith; Hofstetter Helvetica Chimica Acta, 1955 , vol. 38, p. 1085,1089,1091

上下游产品

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110-89-4 554-00-7
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海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%