114607-46-4

• 常用中文名：阿扎司特
• 常用英文名：acitazanolast
• CAS号：114607-46-4
• 分子式：C₉H₇N₅O₃
• 分子量：233.184
• 相关类别： 研究领域 炎症/免疫
• 发布时间：2018-07-28 20:01:16
• 更新时间：2024-01-06 22:14:50
• Acitazanolast是一种口服活性抗过敏药物,可抑制组胺释放。Acitazanolast可用于研究IgE抗体引起的I型过敏反应(立即)[1]。

名称

• 中文名: 阿扎司特
• 英文名: 2-oxo-2-[3-(2H-tetrazol-5-yl)anilino]acetic acid
• 英文别名: MTCC; Oxo((3-(1H-tetrazol-5-yl)phenyl)amino)acetic Acid; acitazanolast; Oxo{[3-(2H-tetrazol-5-yl)phenyl]amino}acetic acid; Acetic acid, 2-oxo-2-[[3-(2H-tetrazol-5-yl)phenyl]amino]-; WP-871; Acitazanolast,WP-871

物化性质

• 密度: 1.7±0.1 g/cm3
• 分子式: C₉H₇N₅O₃
• 分子量: 233.184
• 精确质量: 233.054886
• PSA: 120.86000
• LogP: 0.29
• 折射率: 1.719

生物活性

• 描述: Acitazanolast是一种口服活性抗过敏药物,可抑制组胺释放。Acitazanolast可用于研究IgE抗体引起的I型过敏反应(立即)[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AJ1476901 CHEMICAL NAME : Acetic acid, oxo-((3-(1H-tetrazol-5-yl)phenyl)amino)- CAS REGISTRY NUMBER : 114607-46-4 LAST UPDATED : 199512 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C9-H7-N5-O3 MOLECULAR WEIGHT : 233.21 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,111,1995 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1927 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Blood - normocytic anemia REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,111,1995 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >1500 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Cardiac - arrhythmias (including changes in conduction) Gastrointestinal - nausea or vomiting REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,231,1995 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 22680 mg/kg/28D-C TOXIC EFFECTS : Liver - changes in liver weight Blood - changes in platelet count Related to Chronic Data - death REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,107,1989 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 28 gm/kg/4W-I TOXIC EFFECTS : Kidney, Ureter, Bladder - urine volume increased Kidney, Ureter, Bladder - other changes in urine composition Blood - normocytic anemia REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,235,1995