10184-70-0

• 常用中文名：21-脱乙酰草甘膦
• 常用英文名：Anecortave
• CAS号：10184-70-0
• 分子式：C₂₁H₂₈O₄
• 分子量：344.44
• 相关类别： 研究领域 癌症
• 发布时间：2016-11-17 20:40:53
• 更新时间：2026-07-10 11:37:53
• Anecortave(AL-4940)是一种血管生成抑制剂。Anecortave适用于研究渗出性(湿性)年龄相关性黄斑变性以及视网膜肿瘤[1][2]。

名称

• 中文名: 21-脱乙酰草甘膦
• 英文名: (8S,10S,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one
• 中文别名: 氢化可的松杂质22; 17,21-二羟基孕甾-4,9-二烯-3,20-二酮; 氢化可的松杂质38; 21-脱乙酰阿奈可他; 21-去乙酰阿奈可他; 21-去乙酰安可托韦
• 英文别名: 17-Desacetyl Anecortave; (1R,3aS,3bS,9aS,11aS)-1-Hydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,11H,11aH-cyclopenta[a]phenanthren-7-one; Hydrocortisone Impurity 38; (8S,10S,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one; 21-Desacetyl Anecortave; 17,21-dihydroxy-pregna-4,9(11)-diene-3,20-dione; ANECORTAVE ACETATE RELATED COMPOUND A (20 MG) (9-DEHYDROCORTISOL); Zolpidem Impurity 63-d6; (8S,10S,13S,14S,17R)-17-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,10,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one; Delta-9-Susbtance ‘S’; 17,21-Dihydroxypregna-4,9-diene-3,20-dione; 17,21-Dihydroxy-pregna-4,9(11)-dien-3,20-dion; Pregna-4,9-diene-3,20-dione, 17,21-dihydroxy

物化性质

• 分子式: C₂₁H₂₈O₄
• 分子量: 344.44
• 精确质量: 344.19900
• PSA: 74.60000
• LogP: 2.73090

生物活性

• 描述: Anecortave(AL-4940)是一种血管生成抑制剂。Anecortave适用于研究渗出性(湿性)年龄相关性黄斑变性以及视网膜肿瘤[1][2]。
• 相关类别:
  研究领域 >> 癌症
• 参考文献:

  [1]. Kaiser PK, et al. Posterior juxtascleral depot administration of anecortave acetate. Surv Ophthalmol. 2007 Jan;52 Suppl 1:S62-9.

  [2]. Jockovich ME, et al. Anecortave acetate as single and adjuvant therapy in the treatment of retinal tumors of LH(BETA)T(AG) mice. Invest Ophthalmol Vis Sci. 2006 Apr;47(4):1264-8.

合成路线

119669-94-2 ~% 10184-70-0

文献：Breslow, Ronald; Brandl, Michael; Hunger, Juergen; Adams, Alan D. Journal of the American Chemical Society, 1987 , vol. 109, # 12 p. 3799 - 3801

108674-98-2 ~% 10184-70-0

文献：Breslow, Ronald; Brandl, Michael; Hunger, Juergen; Adams, Alan D. Journal of the American Chemical Society, 1987 , vol. 109, # 12 p. 3799 - 3801

7753-60-8 ~% 10184-70-0

文献：Audouin, Max; Levisalles, Jacques Bulletin de la Societe Chimique de France, 1985 , # 6 p. 1280 - 1284

428516-04-5 ~% 10184-70-0

文献：Bernstein et al. Journal of the American Chemical Society, 1953 , vol. 75, p. 4830

566-35-8 ~% 10184-70-0

文献：Fried; Sabo Journal of the American Chemical Society, 1957 , vol. 79, p. 1130,1137

113862-93-4 ~% 10184-70-0

文献：Fried; Sabo Journal of the American Chemical Society, 1957 , vol. 79, p. 1130,1137

74220-42-1 ~% 10184-70-0

文献：Bernstein et al. Journal of the American Chemical Society, 1953 , vol. 75, p. 4830

76338-54-0 ~% 10184-70-0

文献：Bernstein et al. Journal of the American Chemical Society, 1953 , vol. 75, p. 4830

上下游产品

上游产品  7
108674-98-2 7753-60-8 428516-04-5 566-35-8
113862-93-4 74220-42-1 76338-54-0
下游产品  2
2398-99-4 7753-60-8