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63-25-2生产厂家

63-25-2价格

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63-25-2

63-25-2结构式
63-25-2结构式
  • 常用中文名：甲萘威
  • 常用英文名：carbaryl
  • CAS号：63-25-2
  • 分子式：C12H11NO2
  • 分子量：201.221
  • 相关类别： 化学农药原药 杀虫剂 氨基甲酸酯杀虫剂
  • 发布时间：2018-04-11 08:00:00
  • 更新时间：2024-01-02 17:15:10
  • Carbaryl 可用作杀虫剂。
  • 是氨基甲酸酯类杀虫剂，具有触杀、胃毒作用，微有内吸性质，能防治150多种作物的100多种害虫。可加工成可湿性粉剂或胶悬剂，用于防治水稻稻飞虱、稻叶蝉、棉花红铃虫、大豆食心虫和果树害虫。对有机氯，有机磷有抗性的昆虫有较好的防治效果。用药量一般为每公顷375-750g有效成分。该品不可与碱性农药混配使用。对蜜蜂毒性高，养蜂地区在开花季节不宜使用。 

化源商城直购

中文名 甲萘威
英文名 carbaryl
中文别名 1-萘基-N-甲基氨基甲酸酯
胺甲萘
1-萘基-N-甲基氨基甲酸脂
西维因
虫卯酯
卡巴立
英文别名 1-naphthol N-methylcarbamate
sevin
carbaril
rylam
1-Naphthyl hydrogen methylcarbonimidate
α-Naphthyl methylcarbamate
1-naphthalenol methylcarbamate
1-Naphthalenol, methylcarbamate
α-Naphthalenyl methylcarbamate
Suleo
nmc50
naphthalen-1-yl methylcarbamate
MFCD00021467
1-Naphthyl methylcarbamate
Methanol, 1-(methylimino)-1-(1-naphthalenyloxy)-, (E)-
NMC
1-naphthalenyl N-methylcarbamate
Sewin
1-NAPHTHYL N-METHYLCARBAMATE
SOK
EINECS 200-555-0
NAC
1-Naphthalenyl methylcarbamate
1-naphtalenol
KARL
Carbaryl
naphth-1-yl N-methylcarbamate
α-Naphthyl N-methylcarbamate
Pomex
Mugan
密度 1.1±0.1 g/cm3
沸点 366.5±25.0 °C at 760 mmHg
熔点 142-146 °C(lit.)
分子式 C12H11NO2
分子量 201.221
闪点 175.4±23.2 °C
精确质量 201.078979
PSA 38.33000
LogP 3.35
外观性状 无色至淡黄褐色的晶体
蒸汽压 0.0±0.9 mmHg at 25°C
折射率 1.570
储存条件

本品应密封于阴凉干燥处保存。贮运时应避免与碱性物接触。
稳定性

1. 对光、热和酸性物质较稳定，遇碱性物质易分解。在土壤微生物环境中易降解，生成-萘酚、-萘基-羧基-甲基氨基甲酸酯、-4-羟基-1-萘基-甲基氨基甲酸酯和5-羧基-1-萘基甲基氨基甲酸酯，其中1-萘基-羧基-甲基氨基甲酸酯可能致襄或致突变。

2. 存在于烟叶、烟气中。

3. 对人畜毒性较小。
水溶解性 不溶. 0.00826 G/100 ML
分子结构

1、 摩尔折射率：59.03

2、 摩尔体积（cm3/mol）：169.9

3、 等张比容（90.2K）：440.5

4、 表面张力（dyne/cm）：45.1

5、 极化率（10-24cm3）：23.40
计算化学

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:1

3.氢键受体数量:2

4.可旋转化学键数量:2

5.互变异构体数量:2

6.拓扑分子极性表面积38.3

7.重原子数量:15

8.表面电荷:0

9.复杂度:230

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1
更多

1. 性状：纯品为白色结晶，工业品略带灰色或粉红色

2. 密度（g/mL,20/20℃）：1.232

3. 相对蒸汽密度（g/mL,空气=1）：不确定

4. 熔点（ºC）：142

5. 沸点（ºC,常压）：315

6. 沸点（ºC, 5.2kPa）：不确定

7. 折射率：不确定

8. 闪点（ºC）：202.7

9. 比旋光度（º）：不确定

10. 自燃点或引燃温度（ºC）：不确定

11. 蒸气压（Pa,25ºC）：0.666

12. 饱和蒸气压（kPa,60ºC）：不确定

13. 燃烧热（KJ/mol）：不确定

14. 临界温度（ºC）：不确定

15. 临界压力（KPa）：不确定

16. 油水（辛醇/水）分配系数的对数值：不确定

17. 爆炸上限（%,V/V）：不确定

18. 爆炸下限（%,V/V）：不确定

19. 溶解性：二甲基甲酰胺>45%，丙酮>20%，环己酮>20%，甲乙酮>15%，氯仿>10%，乙醇>5%，甲苯>1%，水40mg/L(30℃)
第一部分：化学品名称
化学品中文名称： 西维因粉剂；1-萘基-N-甲基氨基甲酸酯
化学品英文名称： Sevin powder；1-Naphthyl-N-methyl carbamate
中文俗名或商品名：
Synonyms：
CAS No.： 63-25-2
分子式： C12H11NO2
分子量： 201.22
第二部分：成分/组成信息
纯化学品混合物
化学品名称：西维因粉剂；1-萘基-N-甲基氨基甲酸酯
有害物成分 含量 CAS No.
西维因粉剂 100 63-25-2
第三部分：危险性概述
危险性类别： 第6．1类 毒害品
侵入途径： 吸入 食入 经皮吸收
健康危害： 主要是抑制胆碱酯酶，使乙酰胆碱在组织中蓄积。主要症状为流涎、恶心、流泪、瞳孔缩小、视力模糊、痉挛等。其抑制胆碱酯酶的作用持续时间较短，停止接触后，胆碱酯酶恢复较快。
环境危害：
燃爆危险： 本品可燃，有毒。
危险特性： 5.12 遇明火、高热易引起燃烧。
5.71 受热分解放出有毒气体。
5.108 有毒，遇明火能燃烧。
危险性概述： A198 有毒、可燃
安全措施： B04 远离热源、火种，贮于阴凉通风处
B09 贮于阴凉、通风、干燥处
B51 应与氧化剂、碱类、食用化学品分储
B77 眼睛接触，用流动清水彻底冲洗
B82 误食，饮水，催吐，洗胃，导泄，就医
第四部分：急救措施
皮肤接触： 立即脱去污染的衣着，用肥皂水及流动清水彻底冲洗污染的皮肤、头发、指甲等。就医。
眼睛接触： 立即提起眼睑，用流动清水冲洗10分钟或用2％碳酸氢钠溶液冲洗。
吸入： 迅速脱离现场至空气新鲜处。呼吸困难时给输氧。呼吸停止时，立即进行人工呼吸。就医。
食入： 饮足量温水，催吐。洗胃，导泄。就医。。
第五部分：消防措施
危险特性： 遇明火、高热可燃。与强氧化剂可发生反应。受热分解放出有毒的氧化氮烟气。
有害燃烧产物： 一氧化碳、二氧化碳、氧化氮。
灭火方法及灭火剂： 雾状水、泡沫、二氧化碳、砂土。
消防员的个体防护： 消防人员须佩戴防毒面具、穿全身消防服，在上风向灭火。
禁止使用的灭火剂：
闪点(℃)： 无资料
自燃温度(℃)： 无资料
爆炸下限[%(V/V)]： 无资料
爆炸上限[%(V/V)]： 无资料
最小点火能(mJ)：
爆燃点：
爆速：
最大燃爆压力(MPa)：
建规火险分级：
第六部分：泄漏应急处理
应急处理： 隔离泄漏污染区，周围设警告标志，建议应急处理人员戴好防毒面具，穿化学防护服。不要直接接触泄漏物，避免扬尘，用清洁的铲子收集于干燥净洁有盖的容器中，运至废物处理场所。如大量泄漏，收集回收或无害处理后废弃。
第七部分：操作处置与储存
操作注意事项： 密闭操作，提供充分的局部排风。操作尽可能机械化、自动化。操作人员必须经过专门培训，严格遵守操作规程。建议操作人员佩戴自吸过滤式防尘口罩，戴化学安全防护眼镜，穿防毒物渗透工作服，戴乳胶手套。远离火种、热源，工作场所严禁吸烟。使用防爆型的通风系统和设备。避免产生粉尘。避免与氧化剂、碱类接触。搬运时要轻装轻卸，防止包装及容器损坏。配备相应品种和数量的消防器材及泄漏应急处理设备。倒空的容器可能残留有害物。
储存注意事项： 储存于阴凉、通风的库房。远离火种、热源。应与氧化剂、碱类、食用化学品分开存放，切忌混储。配备相应品种和数量的消防器材。储区应备有合适的材料收容泄漏物。
第八部分：接触控制/个体防护
最高容许浓度： 中国MAC：未制定标准苏联MAC：1mg／m3美国TWA：ACGIH 5mg／m3美国S
监测方法：
工程控制： 严加密闭，提供充分的局部排风。尽可能机械化、自动化。提供安全淋浴和洗眼设备。
呼吸系统防护： 生产操作或农业使用时，佩带防毒口罩。紧急事态抢救或逃生时，应该佩带自给式呼吸器。
眼睛防护： 戴安全防护眼镜。
身体防护： 穿相应的防护服。
手防护： 戴防护手套。
其他防护： 工作现场禁止吸烟、进食和饮水。工作后，彻底清洗。工作服不要带到非作业场所，单独存放被毒物污染的衣服，
第九部分：理化特性
外观与性状： 白色结晶，工业品略带灰色或粉红色。
pH：
熔点(℃)： 145
沸点(℃)： 无资料
相对密度(水=1)： 1．23
相对蒸气密度(空气=1)： 无资料
饱和蒸气压(kPa)： 无资料
燃烧热(kJ/mol)：
临界温度(℃)：
临界压力(MPa)：
辛醇/水分配系数的对数值： 无资料
闪点(℃)： 无资料
引燃温度(℃)： 无资料
爆炸上限%(V/V)： 无资料
爆炸下限%(V/V)： 无资料
分子式： C12H11NO2
分子量： 201.22
蒸发速率：
粘性：
溶解性： 不溶于水，溶于乙醇、苯、丙酮等多数有机溶剂。
主要用途： 用作杀虫剂。
第十部分：稳定性和反应活性
稳定性： 在常温常压下 稳定
禁配物： 强氧化剂、强碱。
避免接触的条件：
聚合危害： 不能出现
分解产物： 一氧化碳、二氧化碳、氧化氮。
第十一部分：毒理学资料
急性毒性： 属中等毒类 LD50：250～560mg／kg(大鼠经口)；4000mg／kg(大鼠经皮) LC50：
急性中毒：
慢性中毒：
亚急性和慢性毒性：
刺激性：
致敏性：
致突变性：
致畸性：
致癌性：
第十二部分：生态学资料
生态毒理毒性：
生物降解性：
非生物降解性：
生物富集或生物积累性：
第十三部分：废弃处置
废弃物性质：
废弃处置方法： 根据国家和地方有关法规的要求处置。或与厂商或制造商联系，确定处置方法。
废弃注意事项：
第十四部分：运输信息
危险货物编号： 61888
UN编号： 2757
包装标志：
包装类别： Ⅲ
包装方法： 塑料袋或二层牛皮纸袋外全开口或中开口钢桶；两层塑料袋或一层塑料袋外麻袋、塑料编织袋、乳胶布袋；塑料袋外复合塑料编织袋（聚丙烯三合一袋、聚乙烯三合一袋、聚丙烯二合一袋、聚乙烯二合一袋）；塑料袋或二层牛皮纸袋外普通木箱；螺纹口玻璃瓶、塑料瓶、复合塑料瓶或铝瓶外普通木箱；塑料瓶、两层塑料袋或两层牛皮纸袋（内或外套以塑料袋）外瓦楞纸箱。
运输注意事项： 储存于阴凉、通风仓间内。远离火种、热源。防止阳光直射。保持容器密封。应与氧化剂、碱类、食用化工原料分开存放。不可混储混运。搬运时要轻装轻卸，防止包装及容器损坏。分装和搬运作业要注意个人防护。
RETCS号：
IMDG规则页码：
第十五部分：法规信息
国内化学品安全管理法规：
国际化学品安全管理法规：
第十六部分：其他信息
参考文献： 1.周国泰，化学危险品安全技术全书，化学工业出版社，1997 2.国家环保局有毒化学品管理办公室、北京化工研究院合编，化学品毒性法规环境数据手册，中国环境科学出版社.1992 3.Canadian Centre for Occupational Health and Safety,CHEMINFO Database.1998 4.Canadian Centre for Occupational Health and Safety, RTECS Database, 1989
填表时间： 年月日
填表部门：
数据审核单位：
修改说明：
其他信息： 2
MSDS修改日期： 年月日

毒理学数据:

雄性大鼠急性经口LD50为800mg /kg ,雌性为500 mg /kg。雄性大鼠急性经皮LD50> 4000mg/kg，兔大于2000mg/kg。以含有200mg /kg的词料喂养大鼠2年，没有出现不良反应。对鲤鱼LC50 > 10mg/L (48h),蝉鱼LC50为1 .95mg几(96h)。对野鸭急性经日LD50> 2000mg/kg。对蜜蜂毒性较大。

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FC5950000
CHEMICAL NAME :
Carbamic acid, methyl-, 1-naphthyl ester
CAS REGISTRY NUMBER :
63-25-2
BEILSTEIN REFERENCE NO. :
1875862
LAST UPDATED :
199712
DATA ITEMS CITED :
142
MOLECULAR FORMULA :
C12-H11-N-O2
MOLECULAR WEIGHT :
201.24
WISWESSER LINE NOTATION :
L66J BOVM1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - sensory change involving peripheral nerve Behavioral - muscle weakness
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Autonomic Nervous System - parasympatholytic Cardiac - change in rate Nutritional and Gross Metabolic - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
230 mg/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
64 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
128 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
860 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
370 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
759 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Gastrointestinal - changes in structure or function of salivary glands
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
710 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
223 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC - Lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
>390 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
640 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
829 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - gerbil
DOSE/DURATION :
491 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
510 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
310 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
30 mg/kg/30D-I
TOXIC EFFECTS :
Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1050 mg/kg/21D-I
TOXIC EFFECTS :
Liver - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10800 mg/kg/96D-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
25480 mg/kg/1Y-I
TOXIC EFFECTS :
Endocrine - evidence of thyroid hypofunction Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1109 mg/kg/22W-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphokinase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
214 ug/m3/24H/13W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
720 mg/kg/10D-I
TOXIC EFFECTS :
Biochemical - Neurotransmitters or modulators (putative) - catecholamine levels in CNS Biochemical - Neurotransmitters or modulators (putative) - dopamine at other sites
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
300 mg/kg/50D-C
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Brain and Coverings - other degenerative changes Biochemical - Metabolism (Intermediary) - other proteins
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
23 mg/m3/4H/17W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Behavioral - changes in motor activity (specific assay) Behavioral - alteration of classical conditioning
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
63 mg/kg/4W-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - pig
DOSE/DURATION :
8157 mg/kg/72D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Spinal Cord - other degenerative changes Musculoskeletal - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
13230 mg/kg/14W-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5640 mg/kg/94W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1370 mg/kg
SEX/DURATION :
female 39 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5500 mg/kg
SEX/DURATION :
multigenerations
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
27500 ug/kg
SEX/DURATION :
multigenerations
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
220 mg/kg
SEX/DURATION :
female 5-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1370 mg/kg
SEX/DURATION :
male 39 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5475 mg/kg
SEX/DURATION :
female 52 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Effects on Newborn - live birth index (measured after birth)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
11660 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
100 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
200 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
150 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
900 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
900 mg/kg
SEX/DURATION :
female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
418 mg/kg
SEX/DURATION :
female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
4176 mg/kg
SEX/DURATION :
female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
375 mg/kg
SEX/DURATION :
female 3-62 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - body wall Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - hepatobiliary system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
750 mg/kg
SEX/DURATION :
female 3-62 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
197 mg/kg
SEX/DURATION :
female 1-63 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Newborn - stillbirth
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
394 mg/kg
SEX/DURATION :
female 1-63 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - gastrointestinal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1950 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Maternal Effects - other effects Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2600 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - body wall
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
912 mg/kg
SEX/DURATION :
female 1-16 week(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
300 mg/kg
SEX/DURATION :
female 12-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
250 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
12500 mg/kg
SEX/DURATION :
multigenerations
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
20300 mg/kg
SEX/DURATION :
multigenerations
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
20300 mg/kg
SEX/DURATION :
multigenerations
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
40600 mg/kg
SEX/DURATION :
multigenerations
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
Sperm Morphology
TYPE OF TEST :
Sperm Morphology

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Lung
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 19,369,1977 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 5 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 12,37,1976 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 12,37,1976 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966- Volume(issue)/page/year: 10(3),43,1975 TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 63,1,1976 TOXICOLOGY REVIEW 85ALAU "Carbamate Insecticides: Chemistry, Biochemistry, and Toxicology," Kuhr, R.J., and H.W. Dorough, Cleveland, OH, CRC Press, 1976 Volume(issue)/page/year: -,106,1977 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 5 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,37,1971 OSHA PEL (Gen Indu):8H TWA 5 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 5 mg/m3 JAN 1993 OEL-AUSTRALIA:TWA 5 mg/m3 JAN 1993 OEL-AUSTRIA:TWA 5 mg/m3;Skin JAN 1993 OEL-BELGIUM:TWA 5 mg/m3 JAN 1993 OEL-DENMARK:TWA 5 mg/m3;Skin JAN 1993 OEL-FRANCE:TWA 5 mg/m3 JAN 1993 OEL-GERMANY:TWA 5 mg/m3;Skin JAN 1993 OEL-HUNGARY:STEL 1 mg/m3 JAN 1993 OEL-INDIA:TWA 5 mg/m3 JAN 1993 OEL-JAPAN:TWA 5 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 mg/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 5 mg/m3 JAN 1993 OEL-POLAND:TWA 1 mg/m3 JAN 1993 OEL-RUSSIA:STEL 1 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 5 mg/m3;Skin JAN 1993 OEL-THAILAND:TWA 5 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 5 mg/m3;STEL 10 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CARBARYL-air:10H TWA 5 mg/m3;min expos during pregnancy REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 47800 No. of Facilities: 678 (estimated) No. of Industries: 5 No. of Occupations: 16 No. of Employees: 14120 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 47800 No. of Facilities: 2381 (estimated) No. of Industries: 5 No. of Occupations: 4 No. of Employees: 16544 (estimated) No. of Female Employees: 3228 (estimated)

符号 GHS06 GHS08 GHS09
GHS06, GHS08, GHS09
信号词 Danger
危害声明 H301-H332-H351-H410
警示性声明 P261-P273-P301 + P310 + P330-P304 + P340 + P312-P391-P501
个人防护装备 Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
危害码 (欧洲) Xn:Harmful
风险声明 (欧洲) R22;R40;R50
安全声明 (欧洲) 22-24-36/37-46-61-2-62-60
危险品运输编码 UN 2811 6.1/PG 3
WGK德国 3
RTECS号 FC5950000
包装等级 III
危险类别 6.1(b)
海关编码 2922499916
105-40-8结构式

105-40-8

90-15-3结构式

90-15-3

~%

63-25-2结构式

63-25-2

文献：US5066819 A1, ;
96-31-1结构式

96-31-1

90-15-3结构式

90-15-3

~%

63-25-2结构式

63-25-2

文献：US4987233 A1, ;
75-44-5结构式

75-44-5

90-15-3结构式

90-15-3

~%

63-25-2结构式

63-25-2

文献：US4272441 A1, ;
22013-97-4结构式

22013-97-4

90-15-3结构式

90-15-3

~77%

63-25-2结构式

63-25-2

文献：Degani, Iacopo; Fochi, Rita; Magistris, Claudio Synthesis, 2008 , # 18 art. no. Z09808SS, p. 2919 - 2924
817-73-2结构式

817-73-2

90-15-3结构式

90-15-3

~33%

63-25-2结构式

63-25-2

文献：Kulkarni; Naik; Tandel; Rajappa Tetrahedron, 1991 , vol. 47, # 7 p. 1249 - 1256
132905-86-3结构式

132905-86-3

74-89-5结构式

74-89-5

~74%

63-25-2结构式

63-25-2

文献：Patonay, Tamas; Patonay-Peli, Erzsebet; Mogyorodi, Ferenc Synthetic Communications, 1990 , vol. 20, # 18 p. 2865 - 2885
90-15-3结构式

90-15-3

624-83-9结构式

624-83-9

~%

63-25-2结构式

63-25-2

文献：Journal of Agricultural and Food Chemistry, , vol. 7, p. 612
6642-30-4结构式

6642-30-4

90-15-3结构式

90-15-3

~87%

63-25-2结构式

63-25-2

文献：Kulkarni; Naik; Tandel; Rajappa Tetrahedron, 1991 , vol. 47, # 7 p. 1249 - 1256
90-15-3结构式

90-15-3

~%

63-25-2结构式

63-25-2

文献：Synthetic Communications, , vol. 20, # 18 p. 2865 - 2885

（1）热法：将光气预热至90℃左右，甲胺预热至220℃，按摩尔比1：3：1调节流量进行酰氯化合成反应，该合成器上部温度控制在340～360℃，下部温度控制在240～280℃。控制反应气缓冲出口压力在0.1兆帕以下，酰氯受器和冷凝器夹套水温应严格控制。得到的甲氨基甲酰氯平均含量90%以上，收率83%以上。将甲萘酚和甲氨基甲酰氯以1：1.2的摩尔比投入缩合釜，搅拌反应。工艺过程可采用先将甲氨基甲酰氯溶于四氯化碳、氯苯、甲苯或其他溶剂中，再与甲萘酚反应；也可将其配的5%甲萘酚钠水溶液、3%氢氧化钠溶液及甲氨基甲酰氯溶液投入缩合釜，温度控制在10～15℃、pH8～11下连续反应，溢出的反应物经离心分离、水洗、干燥得甲萘威。

（2）冷法：将甲苯投入搪玻璃反应釜，再加入熔融的甲萘酚，搅拌冷却至-5℃以下，通入光气，同时滴加20%氢氧化钠溶液，反应维持在pH6～7，光化反应完成后，仍在-5℃下滴加一甲胺和氢氧化钠溶液，加完后搅拌保温2小时。将反应液过滤，回收滤液中的甲苯供循环使用，滤饼用稀盐酸和水洗滴，干燥，即得甲萘威，含量约95%，收率90%左右。
备注：对水、日光或热稳定，遇强碱分解成1-萘酚。对人畜毒性较小。对金属、包装材料和应用器械没有腐蚀性。在苹果、梨、白菜、西红柿中的最大允许残留量为5mg/kg，在高粱、桃、杏、蔬菜中则为10mg/kg。ADI为0.01mg/kg。安全间隔期10天。不能在养蜂区施药，以免蜜蜂中毒。对瓜类有药害。解毒药物为阿托品，但不要使用解磷定等肟类药物，治疗时要对症处理，及时控制肺水肿。

3.异氰酸甲酯的制备甲胺与光气在高温下直接进行气相反应，反应器为一管道。反应温度大于400℃，反应器材质为钢衬石墨。防止副产物生成以及杜绝反应器堵塞是生产中关键。异氰酸甲酯分离与精制系统主要设备是脱光气塔，精制异氰酸甲酯塔为90块塔板的浮阀塔，均采用高镍合金钢材料制造。
4.甲萘威的合成反应在溶剂存在下进行，温度60～80℃，稍有负压。生成的混合溶液通过蒸馏，将过量的异氰酸甲酯从蒸馏塔顶部与部分溶剂一起蒸出，再回复使用。甲萘威在溶液中经精制，得纯品。
63-25-2 preparation

海关编码 2922499916
中文概述 2922499916. 甲萘威、地麦威、蜱虱威. 增值税率:17.0%. 退税率:9.0%. 监管条件:ABS(入境货物通关单,出境货物通关单,进出口农药登记证明). 最低关税:6.5%. 普通关税:30.0%
申报要素 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
监管条件 A.入境货物通关单 B.出境货物通关单 S.进出口农药登记证明
检验检疫 P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 M.进口商品检验
Summary 2922499916. VAT:17.0%. Tax rebate rate:9.0%. Supervision conditions:ABS(certificate of inspection for goods inward,certificate of inspection for goods outward,import or export registration certificate for pesticides). MFN tariff:6.5%. General tariff:30.0%

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