52434-75-0

• 常用中文名：LHRH (1-5) (FREE ACID)
• 常用英文名：LHRH (1-5) (free acid) trifluoroacetate salt
• CAS号：52434-75-0
• 分子式：C₃₄H₃₈N₈O₉
• 分子量：702.71
• 相关类别： 研究领域 其他
• 发布时间：2018-12-25 12:24:06
• 更新时间：2026-08-06 12:40:34
• LHRH(1-5)(游离酸)是通过在Tyr55-Gly66位点切割LHRH而产生的多肽。LHRH(1-5)(游离酸)在血管紧张素转化酶(HY-P2983)的催化下转化为LHRH(1-3)和LHRH(4-5)片段[1][2]。

名称

• 中文名: LHRH (1-5) (FREE ACID)
• 英文名: lhrh (1-5)
• 中文别名: 戈舍瑞林杂质13; 黄体生成素释放激素LHRH (FREE ACID); 戈舍瑞林杂质26醋酸盐; 戈舍瑞林杂质41 三氟乙酸盐
• 英文别名: PGLU-HIS-TRP-SER-TYR; 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosine; Leuprorelin (Leuprolide) Impurity 13; Goserelin Impurity 41 TFA Salt; pglu-his-trp-ser-tyr; PYR-HIS-TRP-SER-TYR-OH; Goserelin Impurity 26 Acetate; pyr-his-trp-ser-tyr-oh; LHRH , free acid; Leuprorelin (Leuprolide) Impurity; Goserelin Impurity 13; L-Tyrosine, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl

物化性质

• 分子式: C₃₄H₃₈N₈O₉
• 分子量: 702.71
• 精确质量: 702.27600
• PSA: 267.73000
• LogP: 0.81160

生物活性

• 描述: LHRH(1-5)(游离酸)是通过在Tyr55-Gly66位点切割LHRH而产生的多肽。LHRH(1-5)(游离酸)在血管紧张素转化酶(HY-P2983)的催化下转化为LHRH(1-3)和LHRH(4-5)片段[1][2]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. McDermott JR, et al. Mechanism of degradation of LH-RH and neurotensin by synaptosomal peptidases. Peptides. 1983 Jan-Feb;4(1):25-30.

  [2]. Yokosawa H, et al. Degradation of luteinizing hormone-releasing hormone by neuroblastoma cells and their membrane: evidence for the involvement of a thiol protease and angiotensin-converting enzyme. J Neurochem. 1987 Jan;48(1):293-8.

合成路线

142822-22-8 ~% 52434-75-0

文献：Slomczynska, Urszula; Leplawy, Tomasz; Leplawy, Miroslaw, T. Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1992 , vol. 47, # 10 p. 1424 - 1430

16874-12-7 ~% 52434-75-0

文献：Slomczynska, Urszula; Leplawy, Tomasz; Leplawy, Miroslaw, T. Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1992 , vol. 47, # 10 p. 1424 - 1430

142822-21-7 ~% 52434-75-0

文献：Slomczynska, Urszula; Leplawy, Tomasz; Leplawy, Miroslaw, T. Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1992 , vol. 47, # 10 p. 1424 - 1430

142822-20-6 ~% 52434-75-0

文献：Slomczynska, Urszula; Leplawy, Tomasz; Leplawy, Miroslaw, T. Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1992 , vol. 47, # 10 p. 1424 - 1430

25575-88-6 ~% 52434-75-0

文献：Slomczynska, Urszula; Leplawy, Tomasz; Leplawy, Miroslaw, T. Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1992 , vol. 47, # 10 p. 1424 - 1430

20696-57-5 ~% 52434-75-0

文献：Slomczynska, Urszula; Leplawy, Tomasz; Leplawy, Miroslaw, T. Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1992 , vol. 47, # 10 p. 1424 - 1430

33217-51-5 ~% 52434-75-0

文献：Slomczynska, Urszula; Leplawy, Tomasz; Leplawy, Miroslaw, T. Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1992 , vol. 47, # 10 p. 1424 - 1430

2130-96-3 23680-31-1 13139-14-5 25024-53-7 ~% 详细

文献：Stetler-Stevenson, Mary Alice; Yang, Dai Chang; Lipkowski, Andrew; McCartney, Linda; Peterson, Darryl; Fluoret, George Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 688 - 692

上下游产品

上游产品  9
142822-22-8 16874-12-7 142822-21-7 25575-88-6
20696-57-5 33217-51-5 2130-96-3 23680-31-1
13139-14-5
下游产品  0