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3562-63-8

3562-63-8 structure

3562-63-8 structure

Name: Megestrol
Chemical Name: megestrol
CAS Number: 3562-63-8
Molecular Formula: C₂₂H₃₀O₃
Molecular Weight: 342.472
Catalog: API Hormone and endocrine-regulating drugs Birth control pills
Create Date: 2018-04-15 08:00:00
Modify Date: 2026-07-05 11:00:36
Megestrol is a synthetic progestin and used for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis[1].

Name	megestrol
Synonyms	Megestrol Acetate Impurity 2(Megestrol Acetate Impurity B)(Megestrol) MFCD01939877 Megestrol 100 μg/ml Acetonitrile 20-dione,17-hydroxy-6-methyl-pregna-6-diene-3 Megestrol //BP Metesterone acetate impurity B (8R,9S,10R,13S,14S,17R)-17-Acetyl-17-hydroxy-6,10,13-trimethyl-8,9,10,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one Megesstrol 17-ALPHA-HYDROXY-6-METHYL-4,6-PREGNADIENE-3,20-DIONE 17α-Hydroxy-6-Methyl-4,6-Pregnadiene-3,20-Dione MEGESTROL Megestrol Acetate Impurity 2（Megestrol Acetate Impurity B） 17-alpha-hydroxy-6-methylpregna-4,6-diene-3,20-dione megestrol solution,100ppm Megestrol in Methanol 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione 4,6-PREGNADIEN-6-METHYL-17-OL-3,20-DIONE Megestro Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl EINECS 222-628-6 C07120 17-Hydroxy-6-methyl-pregna-4,6-dien-3,20-dion Megestrol (base and/or unspecified salts) Medroxyprogesterone Acetate Impurit 4 megestrol Megestrol acetate Impurity B 17-hydroxy-6-methylpregna-4,6-diene-3,20-dione

Description	Megestrol is a synthetic progestin and used for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis[1].
References	[1]. Garcia JM, et al. Off-Label Megestrol in Patients with Anorexia-Cachexia Syndrome Associated with Malignancy and Its Treatments. Am J Med. 2018 Jun;131(6):623-629.e1.

Density	1.2±0.1 g/cm3
Boiling Point	500.4±50.0 °C at 760 mmHg
Molecular Formula	C₂₂H₃₀O₃
Molecular Weight	342.472
Flash Point	270.5±26.6 °C
Exact Mass	342.219482
PSA	54.37000
LogP	3.06
Vapour Pressure	0.0±2.9 mmHg at 25°C
Index of Refraction	1.569

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4074500

CHEMICAL NAME :: Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-

CAS REGISTRY NUMBER :: 3562-63-8

LAST UPDATED :: 199606

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H20-O3

MOLECULAR WEIGHT :: 332.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 30 mg/kg/15D-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980- Volume(issue)/page/year: 11(3),17,1991

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