82419-52-1

• 常用中文名：9-氟-2,3二氢-3-甲基-7氧代-10-(1-哌嗪基)-吡啶并[1,2,3-DE]-1,4苯并恶嗪-6羧酸
• 常用英文名：Ofloxacin impurity E
• CAS号：82419-52-1
• 分子式：C₁₇H₁₈FN₃O₄
• 分子量：347.34100
• 相关类别： 原料药 人工合成抗感染类药 喹诺酮类药
• 发布时间：2018-06-22 13:47:08
• 更新时间：2026-07-23 00:25:46

名称

• 中文名: 氧氟沙星相关物质A
• 英文名: N-Demethylofloxacin
• 中文别名: 氧氟沙星相关化合物A; 氧氟沙星杂质5(氧氟沙星杂质E); N-去甲氧氟沙星; 去甲基氧氟沙星 标准品; 去甲基氧氟沙星; 氧氟沙星欧洲药典杂质E; 9-氟-2,3-二氢-3-甲基-7-氧代-10-(1-哌嗪基)-7H-吡啶并[1,2,3-DE]-1,4-苯并恶嗪-6-羧酸; 氧氟沙星杂质E 标准品; OFLOXACIN 杂质 E; 氧氟沙星杂质E; 去甲基盐酸氧氟沙星; 氧氟沙星相关物质A 标准品; 氧氟沙星杂质E、氧氟沙星相关物质A
• 英文别名: N-desmethyl ofloxacin; Ofloxacin Related CoMpound A; (RS)-9-Fluoro-2,3-dihydro-3-methyl-10-(1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-cboxylic acid HCl; Ofloxacin Related Compound A (25 mg); UNII-5S4363I4ED; Ofloxacin Related Compound A (25 mg) (9-Fluoro-3-methyl-7-oxo-10-(piperazin-1-yl)-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-cboxylic acid); Ofloxacin-3; N-demethyl ofloxacin; Ofloxacin impurity E CRS; (RS)-9-Fluoro-3-methyl-7-oxo-10-(piperazin-1-yl)-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-c; Ofloxacin IMpurity E; 9-Fluoro-2,3-dihydro-3-methyl-7-oxo-10-(1-piperazinyl)-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-cboxylic acid - [AC78643]; (RS)-9-Fluoro-3-methyl-7-oxo-10-(pi; (R)-9-fluoro-3-methyl-7-oxo-10-(piperazin-1-yl)-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-cboxylic acid; Ofloxacin related compound A; Ofloxacin Related Compound A (9-Fluoro-3-methyl-7-oxo-10-(piperazin-1-yl)-2,3-dihydro-7H-pyrido[1,2; OFLOXACIN RELATED COMPOUND A (25 MG) ((RS)-9-FLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-10-(PIPERA-ZIN-1 -YL)-7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CBOXYLIC ACID); OFLOXACIN RELATED COMPOUND A //BP; Desmethyl Ofloxacin (Ofloxacin Impurity E); 9-Fluoro-2,3-dihydro-3-methyl-7-oxo-10-(1-piperazinyl)-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-cboxylic Acid Hydrochloride; 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-cboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-7-oxo-10-(1-piperazinyl); 9-Fluoro-2,3-dihydro-3-methyl-7-oxo-10-(1-piperazinyl)-7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-cboxylic Acid; (RS)-9-Fluoro-3-methyl-7-oxo-10-(piperazin-1-yl)-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-cboxylic Acid; Desmethyl Ofloxacin Hydrochloride; 9-Fluoro-3-methyl-7-oxo-10-(piperazin-1-yl)-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-cboxylic acid; Ofloxacin Related Compound A (25 mg) ((RS)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-10-(piperazin-1-yl)-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-cboxylic acid); Ofloxacin Impurity E (Desmethyl Ofloxacin); Ofloxacin Impurity 5(Ofloxacin Impurity E); OFLOXACIN RELATED COMPOUND A (25 MG) ((RS)-9-FLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-10-(PIPERA-ZIN-1 -YL)-7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CBOXYLIC ACID) //BP; Ofloxacin Impurity 5（HCl）; 9-fluoro-3-methyl-7-oxo-10-(piperazin-1-yl)-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-cboxylic acid; Ofloxacin Impurity E RC A); (RS)-9-fluoro-2,3-dihydro-3-Methyl-7-oxo-10-(piperazin-1-yl)-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-cboxylic acid; Ofloxacin Impurity E (Ofloxacin Related Compound A); Desmethyl Ofloxacin

物化性质

• 熔点: >250ºC (dec.)
• 分子式: C₁₇H₁₈FN₃O₄
• 分子量: 347.34100
• 精确质量: 347.12800
• PSA: 83.80000
• LogP: 1.59560
• 外观性状: 固体
• 储存条件: -20?C Freezer

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 警示性声明: P301 + P312 + P330
• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 22
• 危险品运输编码: NONH for all modes of transport

合成路线

110-85-0 82419-35-0 ~93% 82419-52-1

文献：Organic and Biomolecular Chemistry, , vol. 9, # 24 p. 8288 - 8300

771-69-7 ~% 82419-52-1

文献：Chemical and Pharmaceutical Bulletin, , vol. 32, # 12 p. 4907 - 4913

82419-32-7 ~% 82419-52-1

文献：Chemical and Pharmaceutical Bulletin, , vol. 32, # 12 p. 4907 - 4913

82419-26-9 ~% 82419-52-1

文献：Chemical and Pharmaceutical Bulletin, , vol. 32, # 12 p. 4907 - 4913

82419-34-9 ~% 82419-52-1

文献：Chemical and Pharmaceutical Bulletin, , vol. 32, # 12 p. 4907 - 4913

82419-33-8 ~% 82419-52-1

文献：Chemical and Pharmaceutical Bulletin, , vol. 32, # 12 p. 4907 - 4913

86760-99-8 ~% 82419-52-1

文献：Chemical and Pharmaceutical Bulletin, , vol. 32, # 12 p. 4907 - 4913

上下游产品

上游产品  8
110-85-0 82419-35-0 771-69-7 82419-32-7
82419-26-9 82419-34-9 82419-33-8 86760-99-8
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