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| 中文名 | 左布地奈德 |
|---|---|
| 英文名 | budesonide |
| 中文别名 | 16alpha,17alpha-22R,S-丙基亚甲基二氧-孕甾-1,4-二烯-11beta,21-二羟基-3,20二酮 |
| 英文别名 |
Budesonide
Respules Spirocort Bidien 2H-Naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-6b-(2-hydroxyacetyl)-4a,6a-dimethyl-8-propyl-, (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)- Budesonide,(11β,16α)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione S-1320 16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione EINECS 257-139-7 Budeson Micronyl Pulmicort MFCD00083259 ENTOCORT Rhinocort (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-6b-Glycoloyl-5-hydroxy-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one 2H-naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-, (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)- PREFERID |
| 描述 | Budesonide是一种具有强效抗炎活性的糖皮质类固醇。 |
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| 相关类别 | |
| 参考文献 |
| 密度 | 1.3±0.1 g/cm3 |
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| 沸点 | 599.7±50.0 °C at 760 mmHg |
| 熔点 | 221-232ºC (dec.) |
| 分子式 | C25H34O6 |
| 分子量 | 430.534 |
| 闪点 | 201.8±23.6 °C |
| 精确质量 | 430.235535 |
| PSA | 93.06000 |
| LogP | 3.14 |
| 外观性状 | 白色固体 |
| 蒸汽压 | 0.0±3.9 mmHg at 25°C |
| 折射率 | 1.592 |
| 储存条件 | 库房通风低温干燥 |
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Section 1. Chemical Product and Company Identification BudesonideCatalog YY448, YY1420, B1581, Common Name/ Number(s). Trade Name 51333-22-3
CAS# Manufacturer Commercial Name(s) Synonym Budesonide Section 4. First Aid Measures Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least Eye Contact 15 minutes. Get medical attention. In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove Skin Contact contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention. Serious Skin ContactWash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention. InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious InhalationNot available. Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an Ingestion unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature Not available. Not available. Flash Points Not available. Flammable Limits These products are carbon oxides (CO, CO2). Products of Combustion Fire Hazards in Presence of Slightly flammable to flammable in presence of heat. Various Substances Risks of explosion of the product in presence of mechanical impact: Not available. Explosion Hazards in Risks of explosion of the product in presence of static discharge: Not available. Presence of Various Substances SMALL FIRE: Use DRY chemical powder. Fire Fighting Media LARGE FIRE: Use water spray, fog or foam. Do not use water jet. and Instructions Not available. Special Remarks on Fire Hazards Not available. Special Remarks on Explosion Hazards Section 6. Accidental Release Measures Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading Small Spill water on the contaminated surface and dispose of according to local and regional authority requirements. Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on Large Spill the contaminated surface and allow to evacuate through the sanitary system. Budesonide Section 7. Handling and Storage Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not Precautions ingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes. Keep container tightly closed. Keep container in a cool, well-ventilated area. Storage Section 8. Exposure Controls/Personal Protection Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below Engineering Controls recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSplash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE of a Large Spill handling this product. Not available. Exposure Limits Section 9. Physical and Chemical Properties Solid.Odorless. Physical state andO dor appearance Not available. Taste 430.59 g/mole Molecular Weight White. Off-white. Color Not applicable. pH (1% soln/water) Not available. Boiling Point 226.5°C (439.7°F) Melting Point Not available. Critical Temperature Not available. Specific Gravity Not applicable. Vapor Pressure Not available. Vapor Density Not available. Volatility Not available. Odor Threshold Not available. Water/Oil Dist. Coeff. Not available. Ionicity (in Water) Not available. Dispersion Properties Insoluble in cold water. Solubility Practically insoluble in Heptane. Sparingly soluble in Ethanol. Freely soluble in Chloroform. Section 10. Stability and Reactivity Data The product is stable. Stability Not available. Instability Temperature Conditions of Instability Excess heat Incompatibility with various Not available. substances Budesonide Non-corrosive in presence of glass. Corrosivity Not available. Special Remarks on Reactivity Not available. Special Remarks on Corrosivity Will not occur. Polymerization Section 11. Toxicological Information Inhalation. Ingestion. Routes of Entry Toxicity to AnimalsAcute oral toxicity (LD50): >3200 mg/kg [Rat]. Chronic Effects on Humans Not available. Hazardous in case of skin contact (irritant). Other Toxic Effects on HumansSlightly hazardous in case of ingestion, of inhalation. Not available. Special Remarks on Toxicity to Animals May cause adverse reproductive effects and birth defects (teratogenic) Special Remarks on Chronic Effects on Humans Potential Health Effects: Special Remarks on other Skin: Causes skin irritation. Toxic Effects on Humans Eyes: Causes eye irritation. Inhalation: May cause respiratory tract irritation. Ingestion: May cause nausea, vomiting, headache, increased thirst/dry mouth, swollen or moon face, swollen ankels, skin striae or markings, acne, respiratory infection. May also affect behavior/central nervous system (Central nervous system depression, confusion, excitement, restlessness, a false sense of well-being, severe mood swings, unusual tiredness or weakness, dizzienss, drowsiness, nervousness or difficulty sleeping), cardiovascular system (irregular heartbeat, chest pain, high blood pressure). May also cause pain in the hips, knees, back, ribs, arms, shoulders, legs, muscle cramps, numbness or tingling in fingers, toes, or other areas, eye pain, decreased or blurred vision, fever, sore throat, sneezing, cough, or other signs of infection, wounds that won't heal, frequent urination, unusual bruising, increased growth of hair on face or body, weight gain or loss Medical Conditions Aggravated by Exposure: Tuberculosis; hypertension; heart problems; diabetes; osteoporosis; glaucoma; cataracts; chronic liver disease; chicken pox or measles; Cushing's Syndrome; stomach or intestinal disease, inclulding colitis; allergic reaction to Budesonide; pregnancy. Section 12. Ecological Information Not available. Ecotoxicity Not available. BOD5 and COD Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. The product itself and its products of degradation are not toxic. Toxicity of the Products of Biodegradation Not available. Special Remarks on the Products of Biodegradation Budesonide Section 13. Disposal Considerations Waste must be disposed of in accordance with federal, state and local environmental control Waste Disposal regulations. Section 14. Transport Information Not a DOT controlled material (United States). DO T Cl assi fi cati on Not applicable. Identification Not applicable. Special Provisions for Transport DO T (Pi ctograms) Section 15. Other Regulatory Information and Pictograms No products were found. Federal and State Regulations California prop. 65: This product contains the following ingredients for which the State of California has found to California cause cancer which would require a warning under the statute: No products were found. Proposition 65 Warnings California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: No products were found. Other RegulationsEINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS no. 257-139-7) Canada: Not listed on Canadian Domestic Substance List (DSL) or Canadian Non- Domestic Substance List (NDSL). China: Not listed on National Inventory. Japan: Not listed on National Inventory (ENCS). Korea: Not listed on National Inventory (KECI). Philippines: Not listed on National Inventory (PICCS). Australia: Not listed on AICS. WHMIS (Canada) CLASS D-2A: Material causing other toxic effects (VERY TOXIC). Other Classifications Class D-2B: Material causing other toxic effects (TOXIC). R36/38- Irritating to eyes and skin.S26- In case of contact with eyes, rinse DSCL (EEC) immediately with plenty of water and seek medical advice. S37- Wear suitable gloves. Health Hazard HMIS (U.S.A.)2 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 2 0 Reactivity Health Reactivity 0 Specific hazard Personal ProtectionE WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) Budesonide TDG(Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. SECTION 16 - ADDITIONAL INFORMATION N/A |
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CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| 个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| 危害码 (欧洲) | Xn:Harmful |
| 风险声明 (欧洲) | R40 |
| 安全声明 (欧洲) | S22-S36 |
| 危险品运输编码 | NONH for all modes of transport |
| WGK德国 | 3 |
| RTECS号 | TU3723000 |
| 海关编码 | 29372900 |
| 海关编码 | 29372900 |
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