574013-66-4

• 常用中文名：3-[3-[(环己基羰基)[[4\'-(二甲基氨基)[1,1\'-联苯]-4-基]甲基]氨基]苯基]-2-丙烯酸甲酯
• 常用英文名：Fexaramine
• CAS号：574013-66-4
• 分子式：C₃₂H₃₆N₂O₃
• 分子量：496.64000
• 相关类别： 信号通路 代谢酶/蛋白酶 FXR
• 发布时间：2017-01-21 17:31:30
• 更新时间：2026-07-03 14:31:46
• Fexaramine是FXR受体小分子激动剂。

名称

• 中文名: Fexaramine
• 英文名: Fexaramine,3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoicacidmethylester
• 中文别名: FEXAMINE,受体(FXR)激动剂; (E)-3-(3-(N-((4'-(二甲基氨基)-[1,1'-联苯]-4-基)甲基)环己烷甲酰胺基)苯基)丙烯酸甲酯; 3-[3-[(环己基羰基)[[4'-(二甲基氨基)[1,1'-联苯]-4-基]甲基]氨基]苯基]-2-丙烯酸甲酯
• 英文别名: Fexamine, 10 mM in DMSO; 2-Propenoic acid, 3-[3-[(cyclohexylcbonyl)[[4'-(dimethylamino)[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-, methyl ester, (2E); (2E,4Z)-5-(3-(N-((4'-(dimethylamino)biphenyl-4-yl)methyl)cyclohexanecboxamido)phenyl)-4-(methoxycbonyl)penta-2,4-dienoic acid; Fexamine; Methyl (E)-3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)cyclohexanecboxamido)phenyl)acrylate; Actosp; Dasan; 3-[3-[(Cyclohexylcbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-pr; (E)-methyl 3-(3-(N-((4'-(dimethylamino)biphenyl-4-yl)methyl)cyclohexanecboxamido)phenyl)acrylate; 2-Propenoic acid, 3-[3-[(cyclohexylcbonyl)[[4'-(diMethylaMino)[1,1'-biphenyl]-4-yl]Methyl]amino]phenyl]-, Methyl ester; 3-[3-[(Cyclohexylcbonyl)[[4'-(dimethylamino)[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-Propenoic acid methyl ester; 3-[3-[(Cyclohexylcbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoicacidmethylester; (E)-methyl 3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)cyclohexanecboxamido)phenyl)acrylate

物化性质

• 密度: 1.158g/cm3
• 沸点: 677.7ºC at 760 mmHg
• 分子式: C₃₂H₃₆N₂O₃
• 分子量: 496.64000
• 闪点: 363.7ºC
• 精确质量: 496.27300
• PSA: 49.85000
• LogP: 6.71930
• 外观性状: yellow solid
• 折射率: 1.626
• 储存条件: -20℃

生物活性

• 描述: Fexaramine是FXR受体小分子激动剂。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> FXR
  研究领域 >> 其他
• 参考文献:

  [1]. Lam IP, et al. Bile acids inhibit duodenal secretin expression via orphan nuclear receptor small heterodimer partner (SHP). Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G90-7.

  [2]. Cho SW, et al. Positive regulation of osteogenesis by bile acid through FXR. J Bone Miner Res. 2013 Oct;28(10):2109-21.

  [3]. Fang S, et al. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb;21(2):159-65.

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302-H413
• 警示性声明: P301 + P312 + P330
• 危险品运输编码: NONH for all modes of transport