916170-19-9

• 常用中文名：AC-55541
• 常用英文名：AC-55541
• CAS号：916170-19-9
• 分子式：C₂₅H₂₀BrN₅O₃
• 分子量：518.362
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 蛋白酶激活受体(PAR)
• 发布时间：2016-03-12 13:09:10
• 更新时间：2026-07-01 09:13:48
• AC-55541是 Protease-activated receptor 2(PAR2)新型小分子激动剂,能激活PAR2的信号转导,EC50值为200-1000nM。

名称

• 中文名: AC-55541
• 英文名: AC 55541
• 中文别名: (E)-N-(2-(2-(1-(3-溴苯基)亚乙基)肼基)-2-氧代-1-(4-氧代-3,4-二氢邻苯二甲嗪-1-基)乙基)苯甲酰胺; AC 55541,蛋白酶激活受体2(P 2)激动剂; AC 55541,PROTEASE-ACTIVATED RECTOR 2 (P2)激动剂
• 英文别名: AC 55541, protease-activated rector 2 (P2) agonist; alpha-(Benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid (2E)-2-[1-(3-bromophenyl)ethylidene]hydrazide; (E)-N-(2-(2-(1-(3-Bromophenyl)ethylidene)hydrazinyl)-2-oxo-1-(4-oxo-3,4-dihydrophthalazin-1-yl)ethyl)benzamide; AC55541; AC-55541; (2E)-2-[1-(3-Bromophenyl)ethylidene] α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid hydrazide AC55541; 1-Phthalazineacetic acid, α-(benzoylamino)-3,4-dihydro-4-oxo-, 2-[(1E)-1-(3-bromophenyl)ethylidene]hydrazide; AC 55541,(2E)-2-[1-(3-Bromophenyl)ethylidene]α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineaceticacidhydrazide; AC 55541,inhibit,AC-55541,AC55541,Inhibitor,Protease Activated Rector (P,Thrombin rectors; AOB2796; 1-Phthalazineacetic acid, α-(benzoylamino)-3,4-dihydro-4-oxo-, (2E)-2-[1-(3-bromophenyl)ethylidene]hydrazide; (E)-N-(2-(2-(1-(3-Bromophenyl)ethylidene)hydrazineyl)-2-oxo-1-(4-oxo-3,4-dihydrophthalazin-1-yl)ethyl)benzamide; (2E)-2-[1-(3-Bromophenyl)ethylidene]α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineaceticacidhydrazide; AC-55541, 10 mM in DMSO; N-[2-{(2E)-2-[1-(3-Bromophenyl)ethylidene]hydrazino}-2-oxo-1-(4-oxo-3,4-dihydro-1-phthalazinyl)ethyl]benzamide; N-({N'-[(1E)-1-(3-bromophenyl)ethylidene]hydrazinecbonyl}(4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzamide; N-[2-{(2E)-2-[1-(3-Bromophenyl)ethylidene]hydrazino}-2-oxo-1-(4-oxo-3,4-dihydrophthalazin-1-yl)ethyl]benzamide

物化性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₂₅H₂₀BrN₅O₃
• 分子量: 518.362
• 精确质量: 517.074951
• PSA: 116.31000
• LogP: 4.65
• 外观性状: 白色至类白色固体
• 折射率: 1.689
• 储存条件: -20℃

生物活性

• 描述: AC-55541是 Protease-activated receptor 2(PAR2)新型小分子激动剂,能激活PAR2的信号转导,EC50值为200-1000nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 蛋白酶激活受体(PAR)
  研究领域 >> 其他
• 参考文献:

  [1]. Gardell LR, et al. Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J Pharmacol Exp Ther. 2008 Dec;327(3):799-808.