1852-49-9

• 常用中文名：妊娠二醇3Α单葡萄糖醛酸苷
• 常用英文名：Pregnanediol 3-glucuronide
• CAS号：1852-49-9
• 分子式：C₂₇H₄₄O₈
• 分子量：496.63300
• 相关类别： 研究领域 内分泌
• 发布时间：2018-12-05 20:38:37
• 更新时间：2026-07-01 10:11:11
• 孕二醇3-葡萄糖醛酸是孕酮的主要终末代谢产物,在生理过程中发挥重要作用,如女性月经周期、妊娠(支持妊娠)、胚胎发生和人类及其他物种的母体免疫反应[1]。

名称

• 中文名: 3-Alpha,20alpha-二羟基-5beta-孕甾3-葡糖苷酸
• 英文名: Pregnanediol 3α-O-β-D-Glucuronide
• 中文别名: 5B-孕烷-3A,20A-二醇葡萄糖醛酸钠孕二醇-3Α-葡萄糖醛酸; 5B-孕烷-3A,20A-二醇葡萄糖醛酸钠妊娠二醇3Α单葡萄糖醛酸苷; 5B-孕烷-3A,20A-二醇葡萄糖醛酸钠(2,3,4,20,C5,); 孕二醇3-O-葡萄糖苷酸; 孕二醇 3Α-O-Β-D-葡糖苷酸; 孕二醇-3Α-葡萄糖醛酸; 孕二醇葡糖苷酸
• 英文别名: 5BETA-PREGNANE-3ALPHA,20ALPHA-DIOL GLUCURONIDE; (2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-[[(3R,5R,8R,9S,10S,13S,14S,17S)-17-[(1S)-1-hydroxyethyl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]tetrahydropyran-2-cboxylic acid; Pregnanediol-3α-Glucuronoside; Pregnanediol 3a-O-β-D-Glucuronide; Pregnanediol-3α-Glucuronide; PREGNANEDIOL GLUCURONIDE; 20α-Hydroxy-5β-pregnan-3α-yl β-D-Glucopyranosiduronic Acid; 5β-Pregnane-3α,20α-diol glucuronide; Pregnanediol 3α-O-β-D-Glucuronide and Pregnanediol 3α-O-α-D-Glucuronide (90:10 mixture); pregnanediol-3alpha-glucuronide; 3alpha,20alpha-dihydroxy-5beta-pregnane 3-glucuronide; 3ALPHA,20ALPHA-DIHYDROXY-5BETA-PREGNANE 3-GLUCURONIDE; 5-BETA-PREGNAN-3-ALPHA, 20-ALPHA-DIOL 3-GLUCOSIDURONATE; 5B-pregnane-3A-20A-diol glucuronide*crystalline; 3α,20α-Dihydroxy-5β-pregnane 3-glucuronide; Pregnanediol 3-Glucuronide; (2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-[[(3R,5R,8R,9S,10S,13S,14S,17S)-17-[(1S)-1-hydroxyethyl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]oxane-2-cboxylic acid; (3α,5β,20S)-20-Hydroxypregnan-3-yl β-D-Glucopyranosiduronic Acid; β-D-Glucopyranosiduronic acid, (3α,5β,20S)-20-hydroxypregnan-3-yl; Pregnanediol 3α-monoglucuronide; Pregnanediol 3-O-Glucuronide

物化性质

• 密度: 1.3g/cm3
• 沸点: 666.4ºC at 760mmHg
• 熔点: >94°C (dec.) (lit.)
• 分子式: C₂₇H₄₄O₈
• 分子量: 496.63300
• 闪点: 217.2ºC
• 精确质量: 496.30400
• PSA: 136.68000
• LogP: 2.30350
• 外观性状: 白色至浅米色固体
• 蒸汽压: 1.34E-20mmHg at 25°C
• 折射率: 1.587
• 储存条件: 20°C，惰性气体

生物活性

• 描述: 孕二醇3-葡萄糖醛酸是孕酮的主要终末代谢产物,在生理过程中发挥重要作用,如女性月经周期、妊娠(支持妊娠)、胚胎发生和人类及其他物种的母体免疫反应[1]。
• 相关类别:
  研究领域 >> 内分泌
• 靶点:

  Human Endogenous Metabolite

• 参考文献:

  [1]. Chen J, et al. Quantitation of serum pregnanediol-3-glucuronide level in different endocrine statuses by LC-MS/MS. J Pharm Biomed Anal. 2020;184:113171.

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3

合成路线

21085-72-3 ~% 1852-49-9

文献：Huebner et al. Journal of Biological Chemistry, 1944 , vol. 155, p. 615

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