17650-86-1

• 常用中文名：友霉素
• 常用英文名：Amicetin
• CAS号：17650-86-1
• 分子式：C₂₉H₄₂N₆O₉
• 分子量：618.67900
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2018-11-25 14:47:19
• 更新时间：2024-04-01 17:52:24
• 阿米西汀是一种强效抗生素。阿米西汀对革兰氏阳性菌具有抗菌活性。Amicetin抑制蛋白质合成[1][2][3]。

名称

• 中文名: 友霉素
• 英文名: Benzamide,4-[[(2S)-2-amino-3-hydroxy-2-methyl-1-oxopropyl]amino]-N-[1-[(2R,5S,6R)-5-[[4,6-dideoxy-4-(dimethylamino)-a-D-glucopyranosyl]oxy]tetrahydro-6-methyl-2H-pyran-2-yl]-1,2-dihydro-2-oxo-4-pyrimidinyl]
• 英文别名: amicetin; Amicetin-A

物化性质

• 密度: 1.46g/cm3
• 分子式: C₂₉H₄₂N₆O₉
• 分子量: 618.67900
• 精确质量: 618.30100
• PSA: 210.73000
• LogP: 0.46960
• 折射率: 1.651
• 储存条件: 库房通风低温干燥

生物活性

• 描述: 阿米西汀是一种强效抗生素。阿米西汀对革兰氏阳性菌具有抗菌活性。Amicetin抑制蛋白质合成[1][2][3]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. HINUMA Y, et al. An amicetin (sacromycin) from Streptomyces sp. No. 5223. Studies on Streptomyces antibiotics. XXXVI. J Antibiot (Tokyo). 1955 Nov;8(5):148-52.

  [2]. Fu, J., et al. Total Synthesis of Nucleoside Antibiotics Amicetin, Plicacetin, and Cytosaminomycin A—D. Chinese Journal of Chemistry, 2021, 39(10), 2679-2684.

  [3]. Ennis, H. L. et, al. Polysome Metabolism in Escherichia coli: Amicetin, an Antibiotic That Stabilizes Polysomes. Antimicrobial Agents and Chemotherapy, 1972, 1(3), 204-209. doi:10.1128/aac.1.3.204.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : BE5950000 CHEMICAL NAME : Amicetin CAS REGISTRY NUMBER : 17650-86-1 BEILSTEIN REFERENCE NO. : 0102092 LAST UPDATED : 199612 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C29-H42-N6-O9 MOLECULAR WEIGHT : 618.77 WISWESSER LINE NOTATION : T6OTJ CQ DN1&1 F1Q BO- DT5OTJ B1 E1 B- AT6NVNJ DMVR DMVXZ1&1Q HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 530 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 57 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 14 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : DNA inhibition TEST SYSTEM : Protozoa - Euglena gracilis DOSE/DURATION : 1500 mg/L REFERENCE : NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4- 1957- Volume(issue)/page/year: 19,579,1972

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