1173-26-8

• 常用中文名：肾上腺酮21-乙酯
• 常用英文名：Pregn-4-ene-3,20-dione,21-(acetyloxy)-11-hydroxy-, (11b)-
• CAS号：1173-26-8
• 分子式：C₂₃H₃₂O₅
• 分子量：388.49700
• 相关类别： 分析化学 标准品 分析标准品
• 发布时间：2018-06-05 08:00:00
• 更新时间：2024-01-06 12:53:04
• 下载msds

名称

• 中文名: 21-乙酸肾上腺酮
• 英文名: Corticosterone 21-Acetate
• 中文别名: 肾上腺酮21-乙酯; 皮质甾酮-21-乙酸酯
• 英文别名: 11β,21-Dihydroxy-4-pregnene-3,20-dione 21-Acetate; [2-[(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate; EINECS 214-635-8; MFCD00010482

物化性质

• 密度: 1.2g/cm3
• 沸点: 542.2ºC at 760 mmHg
• 熔点: 151ºC
• 分子式: C₂₃H₃₂O₅
• 分子量: 388.49700
• 闪点: 183.5ºC
• 精确质量: 388.22500
• PSA: 80.67000
• LogP: 3.23750
• 蒸汽压: 5.14E-14mmHg at 25°C
• 折射率: 1.556
• 储存条件:

  保持贮藏器密封、储存在阴凉、干燥的地方，确保工作间有良好的通风或排气装置

• 稳定性:

  如果遵照规格使用和储存则不会分解，未有已知危险反应，避免氧化物

• 分子结构:

  1、 摩尔折射率：103.58

  2、 摩尔体积（m³/mol）：322.1

  3、 等张比容（90.2K）：852.5

  4、 表面张力（dyne/cm）: 49.0

  5、 介电常数：无可用

  6、 偶极距（10 ^-24cm ³）：无可用

  7、 极化率：41.06

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:1

  3.氢键受体数量:5

  4.可旋转化学键数量:4

  5.互变异构体数量:15

  6.拓扑分子极性表面积80.7

  7.重原子数量:28

  8.表面电荷:0

  9.复杂度:739

  10.同位素原子数量:0

  11.确定原子立构中心数量:7

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：未确定

  2. 密度（g/cm³,25℃）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：151

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,0.5mmHg）：未确定

  7. 折射率(°)：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º)）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（mmHg,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：未确定

MSDS

Section I.Chemical Product and Company Identification Chemical Name Corticosterone 21-Acetate Portland OR SynonymPregn-4-ene-3,20-dione, 21-(acetyloxy)-11- hydroxy-, (11-beta)- (9 CI) Chemical FormulaC23H32O5 CAS Number1173-26-8 Section II.Composition and Information on Ingredients Toxicology Data Chemical NameCAS Number Percent (%)TLV/PEL Corticosterone 21-AcetateMin. Not available.Not available. 1173-26-8 98.0(HPLC) Section III. Hazards Identification Acute Health EffectsNo specific information is available in our data base regarding the toxic effects of this material for humans. However, exposure to any chemical should be kept to a minimum. Skin and eye contact may result in irritation. May be harmful if inhaled or ingested. Always follow safe industrial hygiene practices and wear proper protective equipment when handling this compound. Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound. Chronic Health EffectsCARCINOGENIC EFFECTS : Not available. MUTAGENIC EFFECTS : Not available. TERATOGENIC EFFECTS : Not available. DEVELOPMENTAL TOXICITY: REPRODUCTIVE EFFECTS: Rat TDLo (intraperitoneal) 250mg/kg, female, 3 Days prior to mating. Toxic Effects: Maternal Effects- Ovaries, fallopian tubes. Maternal Effects- Uterus, cervix, vagina. Maternal Effects- Menstrual cycle changes or disorders. Rat TDLo (intraperitoneal) 250mg/kg, male, 1 Day prior to mating. Toxic Effects: Paternal Effects- Testes, epididymis, sperm duct. Mouse TDLo (subcutaneous) 7200mg/kg, female, 11-14 Days of pregnancy. Toxic Effects: Effects on Fertility- Post-implantation mortality. Effects on Embryo or Fetus- Fetotoxicity. Specific Developmental Abnormalities- Craniofacial. Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions. Section IV.First Aid Measures Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention. Skin Contact In case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention. If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or Inhalation waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not improve. IngestionINDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic material was ingested; the absence of such signs, however, is not conclusive. Continued on Next Page Corticosterone 21-Acetate Section V.Fire and Explosion Data Not available. FlammabilityMay be combustible at high temperature.Auto-Ignition Flash PointsFlammable Limits Not available.Not available. Combustion Products These products are toxic carbon oxides (CO, CO 2). Fire Hazards Not available. Explosion HazardsRisks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in presence of static discharge: Not available. Fire Fighting Media SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet. and Instructions Consult with local fire authorities before attempting large scale fire-fighting operations. Section VI.Accidental Release Measures Spill CleanupLight sensitive material. InstructionsUse a shovel to put the material into a convenient waste disposal container. Finish cleaning the spill by rinsing any contaminated surfaces with copious amounts of water. Consult federal, state, and/or local authorities for assistance on disposal. Section VII. Handling and Storage Handling and StorageLIGHT SENSITIVE. Keep away from heat. Mechanical exhaust required. When not in use, tightly seal the container and store in a dry, cool place. Avoid excessive heat and light. Do not breathe dust. Information Always store away from incompatible compounds such as oxidizing agents. Section VIII. Exposure Controls/Personal Protection Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSplash goggles. Lab coat. Dust respirator. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Be sure to use a MSHA/NIOSH approved respirator or equivalent. Exposure LimitsNot available. Section IX. Physical and Chemical Properties Solubility Physical state @ 20°CSolid. (White powder.)Not available. Not available. Specific Gravity Molecular Weight388.50Partition CoefficientNot available. Boiling Point Not available.Vapor PressureNot applicable. Melting Point145 to 146°C (293 to 294.8°F)Vapor DensityNot available. Refractive IndexNot available.VolatilityNot available. Critical TemperatureNot available.OdorNot available. ViscosityNot available.TasteNot available. Section X.Stability and Reactivity Data Stability This material is stable if stored under proper conditions. (See Section VII for instructions) Conditions of InstabilityLight sensitive. Avoid excessive heat and light. Incompatibilities Reactive with oxidizing agents. Continued on Next Page Corticosterone 21-Acetate Section XI. Toxicological Information RTECS NumberGM7820000 Routes of ExposureEye Contact. Ingestion. Inhalation. Toxicity DataNot available. CARCINOGENIC EFFECTS : Not available. Chronic Toxic Effects MUTAGENIC EFFECTS : Not available. TERATOGENIC EFFECTS : Not available. DEVELOPMENTAL TOXICITY: REPRODUCTIVE EFFECTS: Rat TDLo (intraperitoneal) 250mg/kg, female, 3 Days prior to mating. Toxic Effects: Maternal Effects- Ovaries, fallopian tubes. Maternal Effects- Uterus, cervix, vagina. Maternal Effects- Menstrual cycle changes or disorders. Rat TDLo (intraperitoneal) 250mg/kg, male, 1 Day prior to mating. Toxic Effects: Paternal Effects- Testes, epididymis, sperm duct. Mouse TDLo (subcutaneous) 7200mg/kg, female, 11-14 Days of pregnancy. Toxic Effects: Effects on Fertility- Post-implantation mortality. Effects on Embryo or Fetus- Fetotoxicity. Specific Developmental Abnormalities- Craniofacial. Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions. Acute Toxic EffectsNo specific information is available in our data base regarding the toxic effects of this material for humans. However, exposure to any chemical should be kept to a minimum. Skin and eye contact may result in irritation. May be harmful if inhaled or ingested. Always follow safe industrial hygiene practices and wear proper protective equipment when handling this compound. Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound. Section XII.Ecological Information EcotoxicityNot available. Environmental FateNot available. Section XIII. Disposal Considerations Waste DisposalRecycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when disposing of the substance. Section XIV. Transport Information DOT ClassificationNot a DOT controlled material (United States). PIN NumberNot applicable. Proper Shipping Name Not applicable. Packing Group (PG)Not applicable. DOT Pictograms Section XV. Other Regulatory Information and Pictograms TSCA Chemical InventoryThis product is NOT on the EPA Toxic Substances Control Act (TSCA) inventory. The following notices are required by 40 CFR 720.36 (C) for those products not on the inventory list: (EPA) (i) These products are supplied solely for use in research and development by or under the supervision of a technically qualified individual as defined in 40 CFR 720.0 et sec. (ii) The health risks of these products have not been fully determined. Any information that is or becomes available will be supplied on an MSDS sheet. WHMIS ClassificationNot available. (Canada) EINECS Number (EEC) 214-635-8 EEC Risk Statements Not available. Japanese Regulatory Data Not available. Continued on Next Page SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 2、 生殖毒性： 大鼠生殖毒性试验TDLo：口经，母鼠怀孕后19-22天，40mg/kg。 大鼠生殖毒性试验：引入腹膜，母鼠怀孕后3天，250mg/kg。 小鼠生殖毒性试验：植入皮下，母鼠怀孕后11-14天，400mg/kg 生态学数据: 对水是稍微有危害的不要让未稀释或大量的产品接触地下水、水道或者污水系统，若无政府许可，勿将材料排入周围环境。 CHEMICAL IDENTIFICATION RTECS NUMBER : GM7820000 CHEMICAL NAME : Corticosterone, 21-acetate CAS REGISTRY NUMBER : 1173-26-8 BEILSTEIN REFERENCE NO. : 3225312 LAST UPDATED : 199707 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C23-H32-O5 MOLECULAR WEIGHT : 388.55 WISWESSER LINE NOTATION : L E5 B666 OV MUTJ A1 CQ E1 FV1OV1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 40 mg/kg SEX/DURATION : female 19-22 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - endocrine system REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 140,1360,1972 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 250 mg/kg SEX/DURATION : female 3 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Maternal Effects - menstrual cycle changes or disorders REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 51,309,1977 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 250 mg/kg SEX/DURATION : male 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 51,309,1977 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 250 mg/kg SEX/DURATION : female 3 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles) REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 51,309,1977 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 60 mg/kg SEX/DURATION : female 21-22 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - endocrine system REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 140,1360,1972 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 400 mg/kg SEX/DURATION : female 11-14 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 6,313,1972 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 800 mg/kg SEX/DURATION : female 11-14 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 6,313,1972 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 7200 mg/kg SEX/DURATION : female 11-14 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : NKEZA4 Nippon Koshu Eisei Zasshi. Japanese Journal of Public Health. (Nippon Koshu Eisei Gakkai, 1-29-8 Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1954- Volume(issue)/page/year: 33,165,1986

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H317
• 警示性声明: P280
• 个人防护装备: dust mask type N95 (US);Eyeshields;Faceshields;Gloves
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 43
• 安全声明 (欧洲): 36
• 危险品运输编码: NONH for all modes of transport
• RTECS号: GM7820000

合成路线

50-22-6 108-24-7 ~10% 1173-26-8

文献：Kraan, Gijsbert P. B.; Wee, Kees T. van; Wolthers, Bert G.; Molen, Jan C. van der; Nagel, Gijs T.; et al. Steroids, 1993 , vol. 58, # 10 p. 495 - 503

50-23-7 ~% 1173-26-8

文献：Journal of the Chemical Society, , p. 517

115073-83-1 ~% 1173-26-8

文献：Helvetica Chimica Acta, , vol. 27, p. 1287,1292

565-92-4 ~% 1173-26-8

文献：Helvetica Chimica Acta, , vol. 27, p. 1287,1292

48200-75-5 ~% 1173-26-8

文献：Helvetica Chimica Acta, , vol. 27, p. 1287,1292

57717-92-7 ~% 1173-26-8

文献：Helvetica Chimica Acta, , vol. 27, p. 1287,1292

463-51-4 50-22-6 ~% 1173-26-8

文献：CH204233 , ;

115073-83-1 7726-95-6 64-19-7 ~% 1173-26-8

文献：Helvetica Chimica Acta, , vol. 27, p. 1287,1292

上下游产品

上游产品  9
50-22-6 108-24-7 50-23-7 565-92-4
48200-75-5 57717-92-7 463-51-4 7726-95-6
64-19-7
下游产品  2
50-22-6 298-25-9