7414-95-1

• 常用中文名：Imiclopazine
• 常用英文名：Imiclopazine
• CAS号：7414-95-1
• 分子式：C₂₅H₃₂ClN₅OS
• 分子量：486.07200
• 相关类别： 研究领域 神经疾病
• 发布时间：2016-03-19 02:28:42
• 更新时间：2024-01-05 19:28:41
• Imiclopazine 是一种吩噻嗪衍生物,具有良好的镇静,镇痛,抗攻击和止吐作用。

名称

• 中文名: 盐酸环丙哌嗪
• 英文名: Imidazolidone dihydrochloride
• 英文别名: Chlorimpiphenine dihydrochloride; Chorimpiphenine; P-4241; Chlorimiphene dichloride; Ponsital; Imiclopazine hydrochloride; Chlorimphenine hydrochloride; Imiclopazine dihydrochloride; Asta p 4241

物化性质

• 密度: 1.252g/cm3
• 沸点: 659.8ºC at 760mmHg
• 分子式: C₂₅H₃₂ClN₅OS
• 分子量: 486.07200
• 闪点: 352.8ºC
• 精确质量: 485.20200
• PSA: 58.57000
• LogP: 4.13440

生物活性

• 描述: Imiclopazine 是一种吩噻嗪衍生物,具有良好的镇静,镇痛,抗攻击和止吐作用。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 体外研究: 咪氯哌嗪在P388和P388/ADR细胞中表现出多药耐药(MDR)逆转活性,EC50值均为200μM[2]。
• 参考文献:

  [1]. A Ramu, et al. Reversal of multidrug resistance by phenothiazines and structurally related compounds. Cancer Chemother Pharmacol. 1992;30(3):165-73.

  [2]. D. Lenke, et al. Pharmacological activity of new phenothiazine and azaphenothiazine derivatives. January 1971, Arzneimittel-Forschung. 21:288-293.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NJ0621400 CHEMICAL NAME : 2-Imidazolidinone, 1-(2-(4-(3-(2-chlorophenothiazin-10-yl)propyl)-1-pipe razinyl)ethyl)-3- methyl-, dihydrochloride CAS REGISTRY NUMBER : 7414-95-1 LAST UPDATED : 198910 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C25-H32-Cl-N5-O-S.2Cl-H MOLECULAR WEIGHT : 559.05 WISWESSER LINE NOTATION : T C666 BN ISJ EG B3- AT6N DNTJ D2- AT5NVNTJ C1 &GH 2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 321 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,317,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,317,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 68 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,317,1967