149818-98-4

• 常用中文名：N-叔丁基氧基羰基-氨基-4,4-联苯-R-丙氨酸甲酯
• 常用英文名：methyl (2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(4-phenylphenyl)propanoate
• CAS号：149818-98-4
• 分子式：C₂₁H₂₅NO₄
• 分子量：355.427
• 发布时间：2018-10-05 23:17:15
• 更新时间：2026-07-14 17:18:02

名称

• 中文名: N-叔丁基氧基羰基-氨基-4,4-联苯-R-丙氨酸甲酯
• 英文名: methyl (2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(4-phenylphenyl)propanoate
• 中文别名: 沙库巴曲杂质76; (R)-3-([1,1'-联苯]-4-基)-2-((叔丁氧基羰基)氨基)丙酸甲酯; 沙库巴曲杂质46; 甲基-N-叔-丁基氧羰基-氨基-4,4'-联苯-R-丙氨酸; 沙库必曲(LCZ696)杂质76
• 英文别名: Methyl (2R)-3-(biphenyl-4-yl)-2-[(tert-butoxycbonyl)amino]propanoate; METHYL-N-TERT-BUTYLOXYCBONYL-AMINO-4,4'-BIPHENYL-R-ALANINE; (R)-Methyl 3-([1,1'-biphenyl]-4-yl)-2-((tert-butoxycbonyl)amino)propanoate; Methyl (2R)-3-(biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoate (non-preferred name); Methyl-N-tert-butyloxycarbonyl-amino-4,4'-biphenyl-R-alanine; [1,1'-Biphenyl]-4-propanoic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester, (αR); Sacubitril Impurity 76; methyl (2R)-2-[(2-methylpropan-2-yl)oxycbonylamino]-3-(4-phenylphenyl)propanoate; Methyl (2R)-3-(4-biphenylyl)-2-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)propanoate

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 508.6±50.0 °C at 760 mmHg
• 分子式: C₂₁H₂₅NO₄
• 分子量: 355.427
• 闪点: 261.4±30.1 °C
• 精确质量: 355.178345
• PSA: 64.63000
• LogP: 5.14
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.538

合成路线

149709-56-8 98-80-6 ~99% 149818-98-4

文献：Ksander, Gary M.; Ghai, Raj D.; deJesus, Reynalda; Diefenbacher, Clive G.; Yuan, Andrew; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1689 - 1700

1301706-50-2 98-80-6 ~% 149818-98-4

文献：Ciba-Geigy Corporation Patent: US5217996 A1, 1993 ; US 5217996 A

76757-90-9 ~% 149818-98-4

文献：Ksander, Gary M.; Ghai, Raj D.; deJesus, Reynalda; Diefenbacher, Clive G.; Yuan, Andrew; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1689 - 1700

176794-86-8 ~% 149818-98-4

文献：Blake, James F.; Kallan, Nicholas C.; Xiao, Dengming; Xu, Rui; Bencsik, Josef R.; Skelton, Nicholas J.; Spencer, Keith L.; Mitchell, Ian S.; Woessner, Richard D.; Gloor, Susan L.; Risom, Tyler; Gross, Stefan D.; Martinson, Matthew; Morales, Tony H.; Vigers, Guy P.A.; Brandhuber, Barbara J. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 19 p. 5607 - 5612

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