毒理学数据:
急性毒性:大鼠经口LD50:725mg/kg
有毒,吸入蒸气或粉末或经皮肤吸收均可引起中毒。
生态学数据:
该物质对环境有危害,应特别注意对水体的污染。
CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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BY7900000
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CHEMICAL NAME :
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Aniline, 4,4'-oxydi-
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CAS REGISTRY NUMBER :
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101-80-4
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BEILSTEIN REFERENCE NO. :
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0475735
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LAST UPDATED :
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199710
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DATA ITEMS CITED :
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43
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MOLECULAR FORMULA :
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C12-H12-N2-O
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MOLECULAR WEIGHT :
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200.26
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WISWESSER LINE NOTATION :
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ZR DOR DZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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725 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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365 mg/kg
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TOXIC EFFECTS :
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Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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685 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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300 mg/kg
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TOXIC EFFECTS :
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Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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700 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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650 mg/kg
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TOXIC EFFECTS :
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Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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650 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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4277 mg/kg/13W-C
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TOXIC EFFECTS :
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Endocrine - thyroid weight (goiter) Endocrine - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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619 mg/kg/26W-I
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TOXIC EFFECTS :
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Cardiac - EKG changes not diagnostic of specified effects Vascular - BP elevation not characterized in autonomic section
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1087 mg/kg/15D-I
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TOXIC EFFECTS :
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Endocrine - changes in adrenal weight Endocrine - changes in spleen weight Blood - pigmented or nucleated red blood cells
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
-
Rodent - mouse
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DOSE/DURATION :
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2366 mg/kg/13W-C
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TOXIC EFFECTS :
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Endocrine - thyroid weight (goiter) Endocrine - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
8652 mg/kg/2Y-C
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Endocrine - thyroid tumors
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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8550 mg/kg/76W-I
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TOXIC EFFECTS :
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Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia Skin and Appendages - tumors
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
-
Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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13 gm/kg/2Y-C
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Eye) - tumors Liver - tumors
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
-
7000 mg/kg/39W-I
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TOXIC EFFECTS :
-
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - leukemia
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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19 gm/kg/77W-I
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TOXIC EFFECTS :
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Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Blood - tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
-
Rodent - mouse
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DOSE/DURATION :
-
11 gm/kg/30W-I
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TOXIC EFFECTS :
-
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - leukemia
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TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
8652 mg/kg/2Y-C
-
TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Endocrine - thyroid tumors
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TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
-
Oral
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SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
69216 mg/kg/2Y-C
-
TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Endocrine - thyroid tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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12978 mg/kg/2Y-C
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TOXIC EFFECTS :
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Tumorigenic - neoplastic by RTECS criteria Sense Organs and Special Senses (Eye) - tumors
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TYPE OF TEST :
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Specific locus test
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TYPE OF TEST :
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DNA damage
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TYPE OF TEST :
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Micronucleus test
MUTATION DATA
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TYPE OF TEST :
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Sister chromatid exchange
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TEST SYSTEM :
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Rodent - hamster Ovary
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DOSE/DURATION :
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50 mg/L
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REFERENCE :
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SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 236,933,1987 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,203,1982 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 29,203,1982 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-GERMANY;Carcinogen JAN 1993 OEL-RUSSIA:STEL 5 mg/m3 JAN 1993 OEL-SWITZERLAND;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0239 No. of Facilities: 8 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 45 (estimated)
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