195532-12-8

• 常用中文名：普拉沙星
• 常用英文名：Pradofloxacin
• CAS号：195532-12-8
• 分子式：C₂₁H₂₁FN₄O₃
• 分子量：396.41500
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2016-05-25 21:47:55
• 更新时间：2026-06-30 10:50:15
• Pradofloxacin,第三代氟喹诺酮类抗菌化合物。

名称

• 中文名: 普拉沙星
• 英文名: 7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-8-cyano-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid
• 中文别名: 普拉沙星 Pradofloxacin; 普多沙星; 8-氰基-1-环丙基-6-氟-7-((4aS,7aS)-六氢-1H-吡咯并[3,4-b]吡啶-6(2H)-基)-4-氧代-1,4-二氢喹啉-3-羧酸
• 英文别名: 3-Quinolinecboxylic acid, 8-cyano-1-cyclopropyl-6-fluoro-1,4-dihydro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo; 6s-2,8-diazabicyclo-[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; 8-Cyano-1-cyclopropyl-6-fluoro-7-((4aS,7aS)-hexahydro-1H-pyrrolo[3,4-b]pyridin-6(2H)-yl)-4-oxo-1,4-dihydroquinoline-3-cboxylic acid; 8-cyano-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0] nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; Pradofloxacin [INN]; 8-cyano-1-cyclopropyl-7-((1S,6S)-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecboxylic acid; Pradofloxacin (Veraflox); UNII-6O0T5E048I; 6O0T5E048I; 8-cyano-1-cyclopropyl-7-(1s; Pudofloxacin; 8-cyano-1-cyclopropyl-7-([1S,6S]-2,8-diazabicyclo[4.3.0]nonan-8-yl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; 8-Cyano-1-cyclopropyl-6-fluoro-1,4-dihydro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecboxylic acid; 8-Cyano-1-cyclopropyl-6-fluoro-7-((4aS,7aS)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 8-cyano-1-cyclopropyl-6-fluoro-7-((4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-1,4-dihydroquinoline-3-cboxylic acid; pradofloxacin

物化性质

• 密度: 1.504g/cm3
• 沸点: 664.525ºC at 760 mmHg
• 分子式: C₂₁H₂₁FN₄O₃
• 分子量: 396.41500
• 闪点: 355.692ºC
• 精确质量: 396.16000
• PSA: 98.36000
• LogP: 2.62738
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.691

生物活性

• 描述: Pradofloxacin,第三代氟喹诺酮类抗菌化合物。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Lees P. Pharmacokinetics, pharmacodynamics and therapeutics of pradofloxacin in the dog and cat. J Vet Pharmacol Ther. 2013 Jun;36(3):209-21.

合成路线

117528-65-1 151213-40-0 ~90% 195532-12-8

文献：Adam, Thomas; Wischnat, Ralf; Weidemann, Klaus Patent: US2009/318700 A1, 2009 ; Location in patent: Page/Page column 2 ;

280-57-9 117528-65-1 151213-40-0 ~% 195532-12-8

文献：Bayer Aktiengesellschaft Patent: US6278013 B1, 2001 ;

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