6440-58-0

• 常用中文名：1,3-二羟甲基-5,5-二甲基海因
• 常用英文名：Dimethyloldimethyl hydantoin
• CAS号：6440-58-0
• 分子式：C₇H₁₂N₂O₄
• 分子量：188.181
• 相关类别： 分析化学 分析试剂 离子色谱试剂
• 发布时间：2018-12-07 21:26:15
• 更新时间：2024-01-02 23:48:33
• 【用途一】
  用于洗发香波、护发素、化妆品作杀菌防腐剂
  【用途二】
  洗发香波、护发素、化妆品杀菌防腐剂。

名称

• 中文名: 1,3-二羟甲基-5,5-二甲基海因
• 英文名: Dimethyloldimethyl hydantoin
• 中文别名: DMDM 乙内酰脲; 1,3-二羟甲基-5,5-二甲基乙内酰脲; 1,3-二(羟甲基)-5,5-二甲基咪唑烷-2,4-二酮; 二羟甲基海因
• 英文别名: DMDMH and BIT; 1,3-bis(hydroxymethyl)-5,5-dimethyl-1,3-diazolidine-2,4-dione; EINECS 229-222-8; 1,3-Bis(hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione; 1,3-Dihydroxymethyl-5,5-dimethylhydantoin; Hydantoin, 1,3-bis(hydroxymethyl)-5,5-dimethyl-; Glydant; dimethylol dimethyl hydantion; dimethylol-5,5-dimethylhydantoin; 1,3-Bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione; 2,4-Imidazolidinedione, 1,3-bis(hydroxymethyl)-5,5-dimethyl-; Mackgard DM; 1,3-DIMETHYLOL-5,5-DIMETHYL-HYDANTOIN; DMDMH; dmdmh55; MFCD00467199; 1,3-dimethylol-5,5-dimethyl hydantoin; dimethylol; 1,3-bis; DMDM hydantoin; 1,3-dimethylol-5,5-dimethylhydantoin

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 303.7±52.0 °C at 760 mmHg
• 熔点: 797 °C(lit.)
• 分子式: C₇H₁₂N₂O₄
• 分子量: 188.181
• 闪点: 137.5±30.7 °C
• 精确质量: 188.079712
• PSA: 81.08000
• LogP: -1.95
• 外观性状: 液体
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.529
• 储存条件:

  本品内用塑料瓶外用纸箱包装，每瓶10kg、每箱10瓶；采用塑料桶包装，每桶25kg。储存于避光、阴凉、干燥处，室温密闭保存，避免冷冻环境。保质期24个月。

• 计算化学:

  1.疏水参数计算参考值（XlogP）:-0.2

  2.氢键供体数量:2

  3.氢键受体数量:4

  4.可旋转化学键数量:2

  5.互变异构体数量:无

  6.拓扑分子极性表面积81.1

  7.重原子数量:13

  8.表面电荷:0

  9.复杂度:251

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1.性状：无色至淡黄色透明液体

  2.相对密度(25℃)：1.16

  3.凝固点（℃）：-11

  4.溶解性：易溶于水、低级醇，在水相及油水乳液中保持稳定抗菌性能。

毒性和生态

毒理学数据: 本品无毒，豚鼠急性经口毒性LD50＞4000mg/kg，老鼠急性经口毒性LD50＞6000mg/kg。 CHEMICAL IDENTIFICATION RTECS NUMBER : MT9191500 CHEMICAL NAME : Hydantoin, 1,3-bis(hydroxymethyl)-5,5-dimethyl- CAS REGISTRY NUMBER : 6440-58-0 LAST UPDATED : 199701 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C7-H12-N2-O4 MOLECULAR WEIGHT : 188.21 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit REFERENCE : JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 7(3),245,1988 ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Gastrointestinal - ulceration or bleeding from stomach Liver - other changes Kidney, Ureter, Bladder - other changes REFERENCE : JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 7(3),245,1988 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 40,1705,1976 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1320 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 40,1705,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9646 No. of Facilities: 2940 (estimated) No. of Industries: 12 No. of Occupations: 38 No. of Employees: 88285 (estimated) No. of Female Employees: 67234 (estimated)

安全

• 危害码 (欧洲): Xi: Irritant;
• 风险声明 (欧洲): 22-36-43
• 安全声明 (欧洲): 26-36/37
• 海关编码: 2933990090

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%