25561-30-2

• 常用中文名：N,O-双(三甲基硅烷基)三氟乙酰胺
• 常用英文名：bis(trimethylsilyl)trifluoroacetamide
• CAS号：25561-30-2
• 分子式：C₈H₁₈F₃NOSi₂
• 分子量：257.401
• 相关类别： 化学试剂 有机试剂 硅烷
• 发布时间：2018-11-28 17:30:02
• 更新时间：2026-07-01 12:55:44
• 【用途一】
  医药中间体，中性硅烷化保护剂，主要用于合成头孢类抗生素

名称

• 中文名: N,O-双(三甲基硅烷基)三氟乙酰胺
• 英文名: N,O-bis(trimethylsilyl)trifluoroacetamide
• 中文别名: N,O-双(三甲基硅基)三氟乙酰胺试剂盒 BSTFA; N,O-双三甲硅基三氟乙酰胺 含 TMCS; N,O-双三甲硅基三氟乙酰胺; 氮,氧-双(三甲基硅基)三氟乙酰胺; N,O-双三甲硅基三氟乙酰胺,WITHTMCS,PACKAGEDUNDERGONINRESEALABLECHEMSEAL^TBOTTLES; 双(三甲基甲硅烷基)三氟乙酰胺; BSTFA[=N,O-双(三甲基硅基)三氟代乙酰胺][用气相色谱]; BSTFA,衍生化; N,O-双三甲硅基三氟乙酰胺 PACKAGED UNDER GON IN RE; N,O-双(三甲基硅)三氟乙酰胺(三甲基氯硅烷作稳定剂); BSTFA,衍生化级; N,O-双(三甲基硅基)三氟代乙酰胺; 氮,氧-双(三甲基硅烷基)三氟乙酰胺; N,O-双(三甲; N,O-双(三甲基硅基)三氟乙酰胺BSTFA; BSTFA-TMCS(99:1)[用于气相色谱的衍生试剂]; N,O-双(三甲基硅烷基)三氟; N,O-双三甲硅基三氟乙酰胺, 含 TMCS, 氩气下可重封的CHEMSEAL瓶包装; 双三甲基硅烷三氟乙酰; N,O-双(三甲基硅烷)三氟乙酰胺; BSTFA[=N,O-双(三甲基硅基)三氟代乙酰胺](,用于气相色谱); BSTFA二(三甲基硅烷基)三氟乙酰胺; N,O-双(三甲基硅基)三氟乙酰胺 配件; 雙(三甲基矽基)三氟乙醯胺; BSTFA[=N,O-双(三甲基硅基)三氟代乙酰胺); N,O-双(三甲基硅烷基)三氟乙酰胺 G; N,O-BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE别名: N,O-双(三甲基硅烷基)三氟乙酰胺; N,O-双(三甲基硅烷基)三氟乙酰胺(含TMCS); 双三甲硅基三氟乙酰胺; N,O-双(三甲基硅)三氟乙酰胺(含三甲基氯; N,O-双(三甲硅基)三氟; 双(三甲基硅基)三氟乙酰胺; N,O-双(三甲基硅烷基)三氟乙酰胺(BSTFA),用于衍生化; 二(三甲基硅基)三氟乙酰胺; N,O-双(三甲基硅基)三氟乙酰胺; N,O-双三氟甲基硅基三氟乙酰胺; N,O-双三甲硅基三氟乙酰胺, WITH TMCS; N,O-双(三甲基硅烷基)三氟乙酰胺(BSTFA); N,O-双三甲硅基三氟乙酰胺,PACKAGEDUNDERGONINRESEALABLECHEMSEAL^TBOTTLES; N,O-双三甲硅基三氟乙酰胺, 含 TMCS; N,O-双(三甲基硅)三氟乙酰胺; N,O-双(三甲基硅烷基)三氟乙酰胺,含三甲基氯硅烷(用于气相色谱); N,O-双三甲硅基三氟乙酰胺, WITH TMCS, PACKAGED UNDER G; N,O-双(三甲基硅烷基); N,O-双三甲硅基三氟乙酰胺 氩气下可重封的CHEMSEAL瓶包装; N,O-双(三甲基硅基)三氟乙酰胺, J&KSEAL瓶; N,O-双(三甲基硅烷基)三氟乙酰胺:三甲基氯硅烷混合液; 双三甲基硅烷三氟乙酰胺; 硅烷化混合物 FLUKA V; N,O-双(三甲基硅)三氟乙酰胺(含三甲基氯硅烷); N,O-双(三甲基硅烷基)三氟甲基乙酰胺
• 英文别名: BSTFA [=N,O-Bis(trimethylsilyl)trifluoroacetamide]; N,O-Bis(trimethylsilyl)trifluoroacetamide Kit BSTFA 1 mL × Bis(trimethylsilyl); BSTFA (with TMCS), 10 amps; N,O-Bis(trimethylsilyl)trifluoroacetamide packaged under gon in resealable ChemSeal^t bottl; N,O-Bis(trimethylsilyl)trifluoroacetamide; N-(Trimethylsilyl)-1-(trimethylsilyloxy)-2,2,2-trifluoroethanimine; EINECS 247-103-9; N,O-Bis(trimethylsilyl)trifluoroacetamide, with TMCS, packaged under gon in resealable ChemSeal^t bottles; BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE WITH TMCS; N.O-Bis(trimethylsilyl)trifluoro acetamide (BSTFA); BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE(BSTFA); N,O-Bis(trimethylsilyl)trifluoroacetimide; Acetamide, 2,2,2-trifluoro-O,N-bis(trimethylsilyl); N,0-Bis(trimethylsilyl)trifluoroacetamideBSTFA; N,O-BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE WITH TRIMETHYLCHLOROSILANE, (EXCLUDING TMCS); N,O-Bis(trimethylsilyl)trifluoroacetamide J&KSeal; bstfa + tmcs; N,O-Bis(trimethylsilyl)trifluoroacetamide, with TMCS, packaged under gon in resealable ChemSeal; 2,2,2-Trifluoro-N,N-bis(trimethylsilyl)acetamide; MFCD00008269; Bis(trimethylsilyl)trifluoroacetamide; 2,2,2-Trifluoro-N-(trimethylsilyl)acetimidic acid trimethylsilyl ester; N,O-Bis(trimethylsilyl)trifluoroacetamide, , BSTFA; N.O-Bis(Trimethylsilyl)Trifluoroacetamide(Bstfa),Finasteride; 2,2,2-Trifluoro-N-(trimethylsilyl)ethanimidic acid trimethylsilyl ester; N,O-BIS(TRIMETHYLSILYL)TRIFLUOROACET-AMI DE TMCS 10X; N,O-BIS(TRIMETHYLSILYL)TRIFLUOROACET-AMI DE, PGE 10 X; 2,2,2-Trifluoro-1-trimethylsiloxy-N-trimethylsilylethanimine; N,O-Bis(trimethylsilyl)trifluoroacetamide, contains TMCS; N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane,BSTFA + TMCS, Silylating mixture Fluka V; N,N-bis(trimethylsilyl)-2,2,2-trifluoroacetamide; N,O-Bis(trimethylsilyl)trifluoroacetamide, contains TMCS, ampuled under gon; N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane,BSTFA + TMCS; BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE WITH TMCS PACKAGED UNDER GON IN RESEALABLE CHEMSEAL– BOTTLES; REGISIL RC-3; REGISIL RC-2; REGISIL RC-1; BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE*(B STFA) WITH; N,O-bis(trimehylsilyl)trifluoroacetamide; BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE, 9; bis(Trifluoromethylsilyl)trifluoroacetamide; 8 Reaction vial,capacity; N,O-Bis(trimethylsilyl)trifluoroacetamide, packaged in ampules; N,O-BIS(TRIMETHYLSILYL)TRIFLUOROACET-AMI DE WITH TMCS; Bis(trimethylsilyl)trifluoroacetamide for gas chromatoaphy; BSTFA-TMCS (99:1) [Derivatizing for; REGISIL(R) RC-1; bstfa kit; BSTFA; BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE, 9 , WITH TMCS; BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE, 9 , DERIVATIZATION ADE; Trimethylsilyl N-(trimethylsilyl)trifluoroacetimidate; N,O-Bis(trimethylsily)trifluoroamide; N,O-bis-TMS-trifluoroacetamide; N,O-Bis(Trimethylsilyl); N,O-bis(trimethylsilyl)acetamide,*with; N,O-BIS(TRIMETHYLSILYL)TRIFLUORO-ACETAMI DE, FOR; N,O-BSTFA; N,O-Bis(trimethylsilyl)trifluoroacetamide packaged under gon in resealable ChemSeal^t bottles; N,O-Bis(trimethylsilyl)trifluoroacetamide derivatization ade; BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE*(B STFA) SEALE; N,O-Bis(trimethylsilyl)trifluoroacetamide, packaged in ampoules; N,O-BIS(TRIMETHYLSILYL) TRIFLUOROACETAMIDE; N,O-Bis(trimethylsilyl)trifluoroacetamide, with trimethylsilyl chloride; N,O-BIS-(TRIMETHYLSILYL)-TRIFLUOR-ACETAM ID; Ethanimidic acid, 2,2,2-trifluoro-N-(trimethylsilyl)-, trimethylsilyl ester; BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE*(B STFA) BULK; BSTFA (with TMCS); BSTFA containing TMCS

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 170.0±50.0 °C at 760 mmHg
• 熔点: -10°C
• 分子式: C₈H₁₈F₃NOSi₂
• 分子量: 257.401
• 闪点: 56.6±30.1 °C
• 精确质量: 257.087891
• PSA: 21.59000
• LogP: 3.42
• 外观性状: 透明至淡黄色透明液体
• 蒸汽压: 1.5±0.3 mmHg at 25°C
• 折射率: 1.396
• 储存条件:

  2-8℃

• 稳定性:

  如果遵照规格使用和储存则不会分解

  避免接触氧化物，酸
• 水溶解性: hydrolyses
• 分子结构:

  1、 摩尔折射率：60.75

  2、 摩尔体积（cm³/mol）：252.8

  3、 等张比容（90.2K）：523.1

  4、 表面张力（dyne/cm）：18.3

  5、 极化率（10-24cm3）：24.08

• 计算化学:

  1、 氢键供体数量：0

  2、 氢键受体数量：5

  3、 可旋转化学键数量：3

  4、 拓扑分子极性表面积（TPSA）：21.6

  5、 重原子数：15

  6、 表面电荷：0

  7、 复杂度：250

  8、 同位素原子数量：0

  9、 确定原子立构中心数量：0

  10、 不确定原子立构中心数量：0

  11、 确定化学键立构中心数量：0

  12、 不确定化学键立构中心数量：1

  13、 共价键单元数量：1

• 更多:

  1. 性状：无色液体。

  2. 密度（g/mL,25/4℃）： 0.969

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）： 未确定

  5. 沸点（ºC,常压）： 145～147

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率： 1.3840

  8. 闪点（ºC）： 23

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：未确定。

MSDS

Name: Bis(trimethylsilyl)trifluoroacetamide packaged in 1 ml ampules Material Safety Data Sheet Synonym: BSTF CAS: 25561-30-2 Section 1 - Chemical Product MSDS Name:Bis(trimethylsilyl)trifluoroacetamide packaged in 1 ml ampules Material Safety Data Sheet Synonym:BSTF Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 25561-30-2 Bis(trimethylsilyl)trifluoroacetamide, 99+% 247-103-9 Hazard Symbols: XI Risk Phrases: 10 36/37/38 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Flammable. Irritating to eyes, respiratory system and skin.Moisture sensitive.The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: No information regarding eye irritation and other potential effects was found. Skin: No information regarding skin irritation and other potential effects was found. Ingestion: The toxicological properties of this substance have not been fully investigated. Inhalation: The toxicological properties of this substance have not been fully investigated. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Inhalation: Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Flammable liquid and vapor. Extinguishing Media: Use agent most appropriate to extinguish fire. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Remove all sources of ignition. Use a spark-proof tool. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Use only in a well-ventilated area. Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Storage: Keep away from heat, sparks, and flame. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Liquid Appearance: clear, colorless Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: 45.0 - 50.0 deg C @ Freezing/Melting Point: -10 deg C Autoignition Temperature: > 300 deg C (> 572.00 deg F) Flash Point: 43 deg C ( 109.40 deg F) Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: hydrolysis Specific Gravity/Density: .9690g/cm3 Molecular Formula: CF3C=NSi(CH3)3OSi(CH3)3 Molecular Weight: 257.39 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, excess heat, electrical sparks. Incompatibilities with Other Materials: Strong oxidizing agents, strong acids. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen fluoride, nitrogen, silicon oxide. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 25561-30-2 unlisted. LD50/LC50: Not available. Carcinogenicity: Bis(trimethylsilyl)trifluoroacetamide, packaged in 1 ml ampules - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA. See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Shipping Name: FLAMMABLE LIQUID, N.O.S.* Hazard Class: 3 UN Number: 1993 Packing Group: III IMO Shipping Name: FLAMMABLE LIQUID, N.O.S. Hazard Class: 3.3 UN Number: 1993 Packing Group: III RID/ADR Shipping Name: FLAMMABLE LIQUID, N.O.S. Dangerous Goods Code: 3(31C) UN Number: 1993 Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI Risk Phrases: R 10 Flammable. R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 16 Keep away from sources of ignition - No smoking. S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 25561-30-2: No information available. United Kingdom Occupational Exposure Limits Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 25561-30-2 is not listed on Canada's Ingredient Disclosure List. Exposure Limits US FEDERAL TSCA CAS# 25561-30-2 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 主要的刺激性影响： 在皮肤上面： 在皮肤和粘膜上造成腐蚀性影响 刺激皮肤和粘膜 在眼睛上面: 强烈的腐蚀性影响 刺激的影响 致敏作用：没有已知的敏化作用。 生态学数据: 对水是稍微危害的，若无政府许可，勿将材料排入周围环境

安全

• 符号: GHS02, GHS05
• 信号词: Danger
• 危害声明: H226-H314
• 补充危害声明: Corrosive to the respiratory tract., Reacts violently with water.
• 警示性声明: P280-P305 + P351 + P338-P310
• 个人防护装备: Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
• 危害码 (欧洲): C:Corrosive
• 风险声明 (欧洲): R10;R34
• 安全声明 (欧洲): S26-S36/37/39-S45-S16
• 危险品运输编码: UN 2924 3/PG 3
• WGK德国: 3
• 包装等级: III
• 危险类别: 3
• 海关编码: 29310095

合成路线

75-77-4 354-38-1 ~% 25561-30-2

文献：Chemische Berichte, , vol. 103, p. 553 - 560

354-32-5 1070-89-9 ~% 25561-30-2

文献：Chemische Berichte, , vol. 109, p. 2542 - 2546

上下游产品

上游产品  4
75-77-4 354-38-1 354-32-5 1070-89-9
下游产品  10
106450-25-3 10586-13-7 111878-20-7 111878-21-8
10586-12-6 33581-77-0 354-38-1 55982-15-5
14246-15-2 18037-10-0

海关

海关编码	2931900090
中文概述	2931900090. 其他有机-无机化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%
Summary	2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%