51484-40-3

• 常用中文名：2-([1,1'-联苯]-4-基)-N-(吡啶-2-基)乙酰胺
• 常用英文名：[1,1'-Biphenyl]-4-acetamide,N-2-pyridinyl-
• CAS号：51484-40-3
• 分子式：C₁₉H₁₆N₂O
• 分子量：288.34300
• 相关类别： 研究领域 炎症/免疫
• 发布时间：2018-05-04 08:00:00
• 更新时间：2024-01-09 16:02:53
• 二苯吡酰胺(Z-876)是一种双苯乙醇衍生物,具有显著的抗炎、镇痛、解热和尿酸特性。二苯吡酰胺具有抗血小板聚集活性[1]。

名称

• 中文名: 联苯吡胺
• 英文名: difenpiramide
• 英文别名: Z-876; 2-Biphenylyl-N-pyridylacetamide; 2-(4-phenylphenyl)-N-pyridin-2-ylacetamide; Pyridyl-biphenylyl-acetamide; Difenax; Acetamide,2-biphenylyl-N-pyridyl; Difenpiramide; Diphenpyramide

物化性质

• 密度: 1.192g/cm3
• 沸点: 549ºC at 760 mmHg
• 分子式: C₁₉H₁₆N₂O
• 分子量: 288.34300
• 闪点: 285.8ºC
• 精确质量: 288.12600
• PSA: 41.99000
• LogP: 4.00280
• 折射率: 1.645
• 储存条件: 室温

生物活性

• 描述: 二苯吡酰胺(Z-876)是一种双苯乙醇衍生物,具有显著的抗炎、镇痛、解热和尿酸特性。二苯吡酰胺具有抗血小板聚集活性[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Caliari S, et al. Pharmacological properties of the anti-inflammatory agent pyridyl-biphenylyl-acetamide (diphenpyramide). Arzneimittelforschung. 1977;27(11):2086-2093.

  [2]. Gugliotta L, et al. Farmaci antiinfiammatori e attività antiaggregante piastrinica: la difenpiramide [Anti-inflammatory drugs and platelet anti-aggregation activity: difenpiramide]. G Clin Med. 1976;57(11-12):408-415.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AB4549000 CHEMICAL NAME : Acetamide, 2-biphenylyl-N-pyridyl- CAS REGISTRY NUMBER : 51484-40-3 BEILSTEIN REFERENCE NO. : 0483768 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C19-H16-N2-O MOLECULAR WEIGHT : 288.37 WISWESSER LINE NOTATION : T6NJ BMV1R DR HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1857 mg/kg TOXIC EFFECTS : Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2086,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1396 mg/kg TOXIC EFFECTS : Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2086,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2590 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2086,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1471 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2086,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Behavioral - analgesia Nutritional and Gross Metabolic - body temperature decrease Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 118,729,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 4 gm/kg TOXIC EFFECTS : Behavioral - analgesia Nutritional and Gross Metabolic - body temperature decrease Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 118,729,1979

安全

• 海关编码: 2933399090

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%