24385-10-2

• 常用中文名：阿霉酮
• 常用英文名：adriamycinone
• CAS号：24385-10-2
• 分子式：C₂₁H₁₈O₉
• 分子量：414.36200
• 相关类别： 研究领域 癌症
• 发布时间：2018-08-17 12:00:31
• 更新时间：2026-07-04 09:39:47
• 阿霉素的中间体。

名称

• 中文名: 阿霉酮
• 英文名: adriamycinone
• 中文别名: 阿霉素(阿霉素 杂质 D、表阿霉素 杂质 A); 盐酸多柔比星杂质D; 7,8,9,10-四氢-6,8,10,11-四羟基-8-(羟基乙酰)-1-甲氧基-(8S-CIS)-5,12-并四苯二酮; 盐酸表柔比星杂质A; (8S,10S)-6,8,10,11-四羟基-8-(2-羟基乙酰基)-1-甲氧基-7,8,9,10-四氢并四苯-5,12-酮; 多柔比星杂质D/盐酸表柔比星杂质A; 阿霉素杂质D; 阿霉素杂质4(阿霉素杂质D); 阿霉酮/7,8,9,10-四氢-6,8,10,11-四羟基-8-(羟基乙酰)-1-甲氧基-(8S-CIS)-5,12-并四苯二酮; 阿霉素(阿霉素杂质D,表柔比星杂质A); 多柔比星杂质4; 多柔比星杂质D
• 英文别名: 14-hydroxydaunomycinone; Ccris; 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-8-(2-hydroxyacetyl)-1-methoxy-, (8S,10S); 7,8,9,10-Tetrahydro-6,8,10,11-tetrahydroxy-8-(hydroxy acetyl)-1-methoxy-(8S-cis)-5,12-naphthacenedione; doxorubicin aglycone; D2-N-Nitroso desmethyldoxycycline; (8S,10S)-6,8,10,11-Tetrahydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydronaphthacene-5,12-dion; Doxorubicin Impurity D/irubicin hydrochloride impurity A; Doxorubicin Hydrochloride Impurity D; MFCD00871832; (8S,10S)-7,8,9,10-Tetrahydro-6,8,10,11-tetrahydroxy 8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione; Epirubicin aglycon; Doxorubicinone ((8S,10S)-6,8,10,11-Tetrahydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetr; irubicin aglycone; Doxorubicin aglycone; adriamycinaglycone; Doxorubicinone-13C-D3; 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S,10S); 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis); 8-glycoloyl-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1-methoxy-5,12-Naphthacenedione; (8S,10S)-6,8,10,11-Tetrahydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione; Doxorubicinone (Doxorubicin Impurity D,irubicin Impurity A); DoxorubicinoneQ: What is Doxorubicinone Q: What is the CAS Number of Doxorubicinone Q: What is the storage condition of Doxorubicinone Q: What e the applications of Doxorubicinone; Adriamycin-aglycon; irubicin Hydrochloride Impurity A; (8S,10S)-6,8,10,11-Tetrahydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydronaphthacene-5,12-dione (Doxorubicin Aglycone, Doxorubicinone); Epirubicin aglycone; (8S,10S)-10[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-(bromoacetyl)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione; irubicin aglycon; doxorubicin hydroxyaglycone; (8S,10S)-6,8,10,11-tetrahydroxy-8-(hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione (doxorubicin aglycone, doxorubicinone); Doxorubicinone; ADRIAMYCINONE

物化性质

• 密度: 1.671g/cm3
• 沸点: 726.6ºC at 760 mmHg
• 熔点: 223-225ºC
• 分子式: C₂₁H₁₈O₉
• 分子量: 414.36200
• 闪点: 260.4ºC
• 精确质量: 414.09500
• PSA: 161.59000
• LogP: 0.15390
• 蒸汽压: 3.7E-22mmHg at 25°C
• 折射率: 1.737
• 储存条件: Amber Vial, -20°C Freezer

生物活性

• 描述: 阿霉素是抗癌化疗药物阿霉素的代谢产物[1]。阿霉素是一种有效的人类DNA拓扑异构酶I和拓扑异构酶II抑制剂,IC50分别为0.8μM和2.67μM。
• 相关类别:
  研究领域 >> 癌症
• 参考文献:

  [1]. M Joerger, et al. Pharmacokinetics of low-dose doxorubicin and metabolites in patients with AIDS-related Kaposi sarcoma. Cancer Chemother Pharmacol. 2005 May;55(5):488-96.