76811-98-8

• 常用中文名：4-((4-(4-羟基二苯甲基)-1-哌啶基)-1-氧代丁基)-a,a-二甲基苯乙酸
• 常用英文名：Fexofenadinone
• CAS号：76811-98-8
• 分子式：C₃₂H₃₇NO₄
• 分子量：499.64000
• 发布时间：2018-12-07 17:02:46
• 更新时间：2026-06-30 11:06:58

名称

• 中文名: 4-((4-(4-羟基二苯甲基)-1-哌啶基)-1-氧代丁基)-a,a-二甲基苯乙酸
• 英文名: Fexofenadinone
• 中文别名: 非索非那定酮; 非索非那定杂质 A; 非索芬那定杂质A; 2-(4-(4-(4-(羟基二苯甲基)哌啶-1-基)丁酰基)苯基)-2-甲基丙酸; 2-(4-(4-(4-(羟基二苯甲基)哌啶-1-基)丁酰基)苯基)-2-甲基丙酸 (非索非那定杂质); 非索非那定杂质A 标准品; 盐酸非索非那定杂质A; 非索非那定相关物质A 标准品; 4-((4-(4-羟基二苯甲基)-1-哌啶基)-1-氧代丁基)-A,A-二甲基苯乙酸; 非索非那定杂质A; 非索芬那定杂质1(非索芬那定杂质A); 2-[4-[4-[4-(羟基二苯甲基)-1-哌啶基]-1-氧代丁基]苯基]-2,2-二甲基乙酸; 非索非那定相关化合物A; 非索非那定盐酸盐 杂质A
• 英文别名: Fexofenadine Impurity A Fexofenadine related compound A; Fexofenadine impurity A CRS; 4-(4- (4-hydroxydiphenylmethyl) -1-piperidyl) -1-oxybutyl) -a, A-dimethylphenylacetic acid; Fexofenadine impurity A (Y0000751)Q: What is Fexofenadine impurity A (Y0000751) Q: What is the CAS Number of Fexofenadine impurity A (Y0000751); Fexofenadine Impurity AQ: What is Fexofenadine Impurity A Q: What is the CAS Number of Fexofenadine Impurity A Q: What is the storage condition of Fexofenadine Impurity A Q: What e the applications of Fexofenadine Impurity A; Fexofenadine Related Compound A; 2-[4-[4-[4-(Hydroxydiphenylmethyl)p; 2-[4-[4-[4-(Hydroxydiphenylmethyl)piperidin-1-yl]butanoyl]phenyl]-2-methylpropanoic Acid (Ketofexofenadine); Fexofenadine Impurity 1; Fexofenadine Imp A; 2-[4-[4-[4-(Hydroxydiphenylmethyl)piperidin-1-yl]butanoyl]phenyl]-2-methylpropanoic Acid (Ketofexofe; Fexofenadine Related Compound A (4-[1-oxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-alpha,a; Fexofenadine Impurity A/ Fexofenadine Related Compound A (Fexofenadinone); CUSTOMS SYNTHESIZED CHEMICAL COMPOUNDSMETHYL 2-(4-(4-(4-(HYDROXYDIPHENYLMETHYL)PIPERIDIN-1- YL) BUTANOYL)PHENYL)-2-ME; Fexofenadine hydrochloride impurity A; 4-[4-[4-(Hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]-α,α-dimethylphenylacetic acid; 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanoic acid; Fexofenadine hydrochloride impurity A -G; 2-(4-(4-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanoic acid (Fexofenadine Impurity); Fexofenadine Impurity A; Fexofenadine Impurity 1（Fexofenadine Impurity A）; Fexofenadine Related Compound A (25 mg) (4-[1-oxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-alpha,alpha-dimethyl benzeneacetic acid); 2-(4-{4-[4-(Hydroxy-diphenyl-methyl)-piperidin-1-yl]-butyryl}-phenyl)-2-methyl-propionic acid; FEXOFEDINE IMP-A; FEXOFEDINE IMPURITY A; 2-[4-[4-[4-(HydroxydiphenylMethyl)-1-piperidinyl]-1-oxobutyl]phenyl]-2,2-diMethylacetic Acid; 4-((4-(4-Hydroxydiphenylmethyl)-1-piperidinyl)-1-oxobutyl)-a,a-dimethyl-phenylacetic acid; fexofenadine Imp-A; Benzeneacetic acid, 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]-α,α-dimethyl; 4-[1-Oxo-4-[4-(hydroxydiphenylMethyl)-1-piperidinyl]butyl]-α,α-diMethylbenzeneacetic Acid

物化性质

• 密度: 1.165
• 分子式: C₃₂H₃₇NO₄
• 分子量: 499.64000
• 精确质量: 499.27200
• PSA: 77.84000
• LogP: 5.59770
• 外观性状: 固体
• 储存条件: 2-8°C， 密封， 干燥

安全

• 危害码 (欧洲): Xn
• 危险品运输编码: NONH for all modes of transport

合成路线

832088-68-3 ~96% 76811-98-8

文献：DIPHARMA FRANCIS S.r.I. Patent: US2010/228034 A1, 2010 ; Location in patent: Page/Page column 3 ;

154825-95-3 ~% 76811-98-8

文献：WO2011/158262 A1, ; Page/Page column 12-13 ;

43076-30-8 ~50% 76811-98-8

文献：El Ouarradi, Amane; Salard-Arnaud, Isabelle; Buisson, Didier Tetrahedron, 2008 , vol. 64, # 51 p. 11738 - 11744

154477-55-1 ~% 76811-98-8

文献：WO2005/19175 A1, ; Page/Page column 26-27 ;

1352802-40-4 ~% 76811-98-8

文献：WO2011/158262 A1, ;