40454-21-5

• 常用中文名：IQB-782
• 常用英文名：IQB-782
• CAS号：40454-21-5
• 分子式：C₄H₉N₃O₂S
• 分子量：163.19800
• 相关类别： 研究领域 心血管疾病
• 发布时间：2018-06-26 13:30:59
• 更新时间：2024-01-02 12:51:51
• IQB-782 是一种半胱氨酸衍生物。IQB-782 对凝血酶激活型纤溶抑制剂 (TAFI) 具有抑制作用, Ki(app) 值为 0.14 μM。IQB-782 具有较强的化痰作用。

名称

• 英文名: (2R)-2-(diaminomethylideneamino)-3-sulfanylpropanoic acid
• 英文别名: IQB-782; N-amidino-L-cysteine; CYSTEINE,N-AMIDINO-,L; L-Cysteine,N-(aminoiminomethyl); N-Amidinocysteine; EINECS 254-925-1; N-Guanyl-cysteine

物化性质

• 密度: 1.66g/cm3
• 沸点: 348.5ºC at 760mmHg
• 分子式: C₄H₉N₃O₂S
• 分子量: 163.19800
• 闪点: 164.5ºC
• 精确质量: 163.04200
• PSA: 138.00000
• LogP: 0.04340
• 折射率: 1.673
• 储存条件: -20°C，干燥，密封

生物活性

• 描述: IQB-782 是一种半胱氨酸衍生物。IQB-782 对凝血酶激活型纤溶抑制剂 (TAFI) 具有抑制作用, Ki(app) 值为 0.14 μM。IQB-782 具有较强的化痰作用。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
• 靶点:

  Ki (app): 0.14 μM (TAFI)[1]

• 体外研究: IQB-782抑制TAFI相关的羧肽酶,CPN和CPB的IC50s分别为49μM和12μM[1]。
• 参考文献:

  [1]. Do YH, et al. Inhibition of thrombin activatable fibrinolysis inhibitor by cysteine derivatives. Thromb Res. 2005;116(3):265-71.

  [2]. Moratalla R, et al. Pharmacological study of the new mucolytic drug N-guanyl-cysteine. Arzneimittelforschung. 1986 Jun;36(6):918-23.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : HA1680000 CHEMICAL NAME : Cysteine, N-amidino-, L- CAS REGISTRY NUMBER : 40454-21-5 LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C4-H9-N3-O2-S MOLECULAR WEIGHT : 163.22 WISWESSER LINE NOTATION : ZYM&MYVQ1SH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >6 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,918,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,918,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >6 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,918,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,918,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 685 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,918,1986

安全

• 危害码 (欧洲): Xi
• 海关编码: 2930909090

海关

海关编码	2930909090
中文概述	2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%