IQB-782

Modify Date: 2024-01-02 12:51:51

IQB-782 Structure
IQB-782 structure
Common Name IQB-782
CAS Number 40454-21-5 Molecular Weight 163.19800
Density 1.66g/cm3 Boiling Point 348.5ºC at 760mmHg
Molecular Formula C4H9N3O2S Melting Point N/A
MSDS N/A Flash Point 164.5ºC

 Use of IQB-782


IQB-782 is a cysteine derivative. IQB-782 has inhibition for thrombin activatable fibrinolysis inhibitor (TAFI), with an Ki(app) of 0.14 μM. IQB-782 shows a potent mucolytic-expectorant activity[1][2].

 Names

Name (2R)-2-(diaminomethylideneamino)-3-sulfanylpropanoic acid
Synonym More Synonyms

 IQB-782 Biological Activity

Description IQB-782 is a cysteine derivative. IQB-782 has inhibition for thrombin activatable fibrinolysis inhibitor (TAFI), with an Ki(app) of 0.14 μM. IQB-782 shows a potent mucolytic-expectorant activity[1][2].
Related Catalog
Target

Ki (app): 0.14 μM (TAFI)[1]

In Vitro IQB-782 inhibits TAFI related carboxypeptidases with IC50s of 49 μM and 12 μM for CPN and CPB, respectively[1].
References

[1]. Do YH, et al. Inhibition of thrombin activatable fibrinolysis inhibitor by cysteine derivatives. Thromb Res. 2005;116(3):265-71.

[2]. Moratalla R, et al. Pharmacological study of the new mucolytic drug N-guanyl-cysteine. Arzneimittelforschung. 1986 Jun;36(6):918-23.

 Chemical & Physical Properties

Density 1.66g/cm3
Boiling Point 348.5ºC at 760mmHg
Molecular Formula C4H9N3O2S
Molecular Weight 163.19800
Flash Point 164.5ºC
Exact Mass 163.04200
PSA 138.00000
LogP 0.04340
Index of Refraction 1.673

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HA1680000
CHEMICAL NAME :
Cysteine, N-amidino-, L-
CAS REGISTRY NUMBER :
40454-21-5
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C4-H9-N3-O2-S
MOLECULAR WEIGHT :
163.22
WISWESSER LINE NOTATION :
ZYM&MYVQ1SH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,918,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,918,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,918,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,918,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
685 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,918,1986

 Safety Information

Hazard Codes Xi
HS Code 2930909090

 Customs

HS Code 2930909090
Summary 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

IQB-782
N-amidino-L-cysteine
CYSTEINE,N-AMIDINO-,L
L-Cysteine,N-(aminoiminomethyl)
N-Amidinocysteine
EINECS 254-925-1
N-Guanyl-cysteine