6282-02-6

• 常用中文名：N-羟甲基苯甲酰胺
• 常用英文名：N-hydroxymethylbenzamide
• CAS号：6282-02-6
• 分子式：C₈H₉NO₂
• 分子量：151.163
• 相关类别： 化学试剂 有机试剂 酰胺
• 发布时间：2018-02-18 08:00:00
• 更新时间：2024-01-06 15:29:19
• 【用途一】
  有机合成，染料中间体
  【用途二】
  用作染料、颜料中间体

名称

• 中文名: N-羟甲基苯甲酰胺
• 英文名: N-(Hydroxymethyl)benzamide
• 英文别名: Benzamide, N-(hydroxymethyl)-; EINECS 228-495-0; N-(Hydroxymethyl)benzamide; N-hydroxymethylbenzamide; benzoylamino-methanol; N-Methylolbenzamide; N-Hydroxymethyl-benzamid; MFCD00014415; Benzamidomethanol

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 381.0±25.0 °C at 760 mmHg
• 熔点: 95-100 °C
• 分子式: C₈H₉NO₂
• 分子量: 151.163
• 闪点: 184.2±23.2 °C
• 精确质量: 151.063324
• PSA: 49.33000
• LogP: 0.06
• 外观性状: 白色粉末或晶体
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.564
• 储存条件:

  避光，阴凉干燥处，密封保存

• 稳定性:

  常温常压下稳定，粉末 。

• 分子结构:

  1、 摩尔折射率：41.41

  2、 摩尔体积（m³/mol）：127.2

  3、 等张比容（90.2K）：337.1

  4、 表面张力（dyne/cm）：49.2

  5、 极化率（10 ^-24cm ³）：16.41

• 计算化学:

  1、 疏水参数计算参考值（XlogP）：0.4

  2、 氢键供体数量：2

  3、 氢键受体数量：2

  4、 可旋转化学键数量：2

  5、 互变异构体数量：2

  6、 拓扑分子极性表面积（TPSA）：49.3

  7、 重原子数量：11

  8、 表面电荷：0

  9、 复杂度：130

  10、 同位素原子数量：0

  11、 确定原子立构中心数量： 0

  12、 不确定原子立构中心数量：0

  13、 确定化学键立构中心数量：0

  14、 不确定化学键立构中心数量：0

  15、 共价键单元数量：1

• 更多:

  1. 性状：粉末

  2. 密度（g/mL, 25 ℃ ）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：94-96

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC，18mmHg）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（20ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：未确定

MSDS

Name: N-(Hydroxymethyl)Benzamide 98% Material Safety Data Sheet Synonym: Benzamidomethanol CAS: 6282-02-6 Section 1 - Chemical Product MSDS Name:N-(Hydroxymethyl)Benzamide 98% Material Safety Data Sheet Synonym:Benzamidomethanol Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 6282-02-6 N-(Hydroxymethyl)Benzamide 98% 228-495-0 Hazard Symbols: XI Risk Phrases: 36/37/38 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Irritating to eyes, respiratory system and skin. Potential Health Effects Eye: Causes eye irritation. May cause chemical conjunctivitis. Skin: Causes skin irritation. Ingestion: May cause irritation of the digestive tract. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Inhalation: Causes respiratory tract irritation. Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema. Can produce delayed pulmonary edema. Chronic: Effects may be delayed. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution. Extinguishing Media: Use foam, dry chemical, or carbon dioxide. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 6282-02-6: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: Not available. Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 94-96 deg C Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C8H9NO2 Molecular Weight: 151.0685 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Conditions to Avoid: Incompatible materials, dust generation, excess heat, strong oxidants. Incompatibilities with Other Materials: Oxidizing agents. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 6282-02-6 unlisted. LD50/LC50: Not available. Carcinogenicity: N-(Hydroxymethyl)Benzamide - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA No information available. IMO No information available. RID/ADR No information available. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI Risk Phrases: R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 Wear suitable gloves and eye/face protection. WGK (Water Danger/Protection) CAS# 6282-02-6: 1 Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 6282-02-6 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 6282-02-6 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 主要的刺激性影响： 在皮肤上面：刺激皮肤和粘膜 在眼睛上面：刺激的影响 致敏作用：没有已知的敏化现象 生态学数据: 对水少是稍微危害的，不要让未稀释或大量的产品接触地下水、水道或污水系统 若无政府许可，勿将材料排入周围环境.

安全

• 危害码 (欧洲): Xi:Irritant;
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): S26-S37/39
• WGK德国: 1
• 海关编码: 2924299090

合成路线

55-21-0 ~84% 6282-02-6

文献：American Cyanamid Company Patent: US4395577 A1, 1983 ;

50-00-0 55-21-0 ~56% 6282-02-6 1575-94-6 详细

文献：Getz, John J.; Prankerd, Richard J.; Sloan, Kenneth B. Journal of Organic Chemistry, 1992 , vol. 57, # 6 p. 1702 - 1706

50-00-0 55-21-0 ~72% 6282-02-6

文献：Gupta, Rajive; Paul, Satya; Nanda, Puja Journal of the Indian Chemical Society, 2005 , vol. 82, # 6 p. 573 - 574

58379-67-2 ~4% 13156-28-0 6282-02-6 76965-50-9 详细

文献：Journal of Organic Chemistry, , vol. 52, # 24 p. 5475 - 5478

61652-83-3 ~% 6282-02-6 65-85-0

文献：Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , # 5 p. 563 - 570

50-00-0 55-21-0 ~% 6282-02-6 1575-94-6

文献：Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical, , vol. 23, # 2 p. 159 - 161

50-00-0 55-21-0 121-44-8 ~% 6282-02-6

文献：DE156398 ; DE157355 ; DE158088 ; Justus Liebigs Annalen der Chemie, , vol. 343, p. 226

海关

海关编码	2924299090
中文概述	2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%