157327-96-3

• 常用中文名：N-苯甲酰基-5'-O-[二(4-甲氧基苯基)苯基甲基]-3'-脱氧胞苷 2'-[2-氰基乙基 二异丙基氨基亚磷酸酯]
• 常用英文名：3’-dC(Bz)-2’-phosphor amidite
• CAS号：157327-96-3
• 分子式：C₄₆H₅₂N₅O₈P
• 分子量：833.91
• 相关类别： 信号通路 细胞周期/DNA损伤 核苷抗代谢药/类似物
• 发布时间：2017-09-24 23:40:23
• 更新时间：2026-08-24 18:26:48
• 3'-dC(Bz)-2'-磷脒是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

名称

• 中文名: N-苯甲酰基-5'-O-[二(4-甲氧基苯基)苯基甲基]-3'-脱氧胞苷 2'-[2-氰基乙基 二异丙基氨基亚磷酸酯]
• 英文名: 3'-dc cep
• 中文别名: (2R,3R,5S)-2-(4-苯甲酰氨基-2-氧嘧啶-1(2H)-基)-5-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)四氢呋喃-3-基( 2-氰乙基)二异丙基亚磷酰胺; N-苯甲酰基-5'-O-[二(4-甲氧基苯基)苯基甲基]-3'-脱氧胞苷 2'-[4-氰基乙基 二异丙基氨基亚磷酸酯]; (2R,3R,5S)-2-(4-苯甲酰氨基-2-氧代嘧啶-1(2H)-基)-5-((4-甲氧基苯基)(苯基)甲氧基)甲基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺
• 英文别名: 3'-dC-CE Phosphoramidite; 3’-dC(Bz)-2’-phosphoramidite; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-deoxycytidine 2'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; N4-Benzoyl-5’-O-(4,4-dimethoxytrityl)-3’-deoxycytidine-2’-CED-phosphoramidite; 5'-Dimethoxytrityl-N-benzoyl-3'-deoxyCytidine,2'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Midostaurin; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-deoxy-, 2'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] (9CI); N6-Benzoyl-3'-deoxy-5'-O-DMT-cytidine 2'-CE phosphoramidite; 4-N-benzoyl-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 2-cyanoethyl N,N-diisopropylphosphoramidite; 4'-N-benzoylstaurosporine; 3'-dC(Bz)-2'-phosphor amidite; Cgp 41 251; N6-Benzoyl-5'-O-DMT-3'-deoxycytidine 2'-CE phosphoramidite; 4'-N-benzoyl staurosprine; 3'-dC; (2R,3R,5S)-2-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; Benzoylstaurosporine; 3'-DC C

物化性质

• 分子式: C₄₆H₅₂N₅O₈P
• 分子量: 833.91
• 精确质量: 833.35500
• PSA: 159.99000
• LogP: 8.54318

生物活性

• 描述: 3'-dC(Bz)-2'-磷脒是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
• 参考文献:

  [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

合成路线

124482-92-4 86234-45-9 ~65% 157327-96-3

文献：Jung Kyeong Eun; Switzer Journal of the American Chemical Society, 1994 , vol. 116, # 14 p. 6059 - 6061

102691-36-1 86234-45-9 ~77% 157327-96-3

文献：Kumar, Anil; Dass, Debasis; Atreyi; Rao; Katti Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 10-11 p. 1783 - 1796

40615-36-9 ~% 157327-96-3

文献：Kumar, Anil; Dass, Debasis; Atreyi; Rao; Katti Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 10-11 p. 1783 - 1796

98-88-4 ~% 157327-96-3

文献：Kumar, Anil; Dass, Debasis; Atreyi; Rao; Katti Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 10-11 p. 1783 - 1796

161110-00-5 ~% 157327-96-3

文献：Kumar, Anil; Dass, Debasis; Atreyi; Rao; Katti Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 10-11 p. 1783 - 1796

7057-33-2 ~% 157327-96-3

文献：Kumar, Anil; Dass, Debasis; Atreyi; Rao; Katti Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 10-11 p. 1783 - 1796

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