6223-35-4

• 常用中文名：薁磺酸钠
• 常用英文名：sodium gualenate
• CAS号：6223-35-4
• 分子式：C₁₅H₁₇NaO₃S
• 分子量：300.348
• 相关类别： 化学试剂 有机试剂 磺酸盐/亚磺酸盐
• 发布时间：2018-02-08 08:00:00
• 更新时间：2024-01-02 10:17:28
• Sodium gualenate (Guaiazulenesulfonate sodium) 是桂皮烯的亲水性衍生物,具有优良的抗炎和愈伤作用,主要用于治疗十二指肠溃疡,胃溃疡和胃炎。

名称

• 中文名: 磺酸钠
• 英文名: sodium,3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate
• 中文别名: 薁磺酸钠; 呱仑酸钠; 1,4-二甲基-7-异丙基甘菊环-3-磺酸钠
• 英文别名: sodium 5-isopropyl-3,8-dimethylazulene-1-sulfonate; Gualenate de sodium; sodium gualenate; Azulene sulfonate sodium; 5-isopropyl-3,8-dimethyl-azulene-1-sulfonic acid,sodium-salt; 5-Isopropyl-3,8-dimethyl-azulen-1-sulfonsaeure,Natrium-Salz; Natrii gualenas; Sodium guiazulene sulfonate; Gualenato sodidico; Azulen SN; Azupromin

物化性质

• 熔点: 98°C(lit.)
• 分子式: C₁₅H₁₇NaO₃S
• 分子量: 300.348
• 精确质量: 300.079620
• PSA: 65.58000
• LogP: 4.51650
• 外观性状: 固体;Blue to Dark blue powder to crystaline
• 储存条件: <0°C;存放于惰性气体之中;避免光,湿气 (分解),加热

生物活性

• 描述: Sodium gualenate (Guaiazulenesulfonate sodium) 是桂皮烯的亲水性衍生物,具有优良的抗炎和愈伤作用,主要用于治疗十二指肠溃疡,胃溃疡和胃炎。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 体外研究: 瓜氨酸钠是一种不稳定的化合物,在室温下以固态逐渐分解。加热后,瓜氨酸钠在1周内几乎完全分解。发现用于与水压片的芥酸钠和玉米淀粉(重量比; 1：250)的捏合混合物是稳定的。因此,在生产过程中,瓜氨酸钠可以用水稳定[1]。瓜氨酸钠略微抑制大鼠腹膜肥大细胞释放组胺,并强烈抑制fMLP诱导的白细胞迁移[2]。
• 体内研究: 瓜氨酸钠经常用于治疗人胃炎。细胞保护被定义为瓜氨酸钠保护胃粘膜的主要机制,体内抗菌作用也已被证实[2]。
• 参考文献:

  [1]. Nakamichi K, et al. Stabilization of sodium guaiazulene sulfonate in granules for tableting prepared using a twin-screw extruder. Eur J Pharm Biopharm. 2003 Nov;56(3):347-54.

  [2]. Cao T, et al. Synthesis and Biological Evaluation of 3, 8-dimethyl-5-isopropylazulene Derivatives as Anti-gastric Ulcer Agent. Chem Biol Drug Des. 2016 Aug;88(2):264-71.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : CO4826000 CHEMICAL NAME : 1-Azulenesulfonic acid, 5-isopropyl-3,8-dimethyl-, sodium salt CAS REGISTRY NUMBER : 6223-35-4 LAST UPDATED : 199806 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C15-H18-O3-S.Na MOLECULAR WEIGHT : 301.38 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 6380 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,615,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 180 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - ataxia REFERENCE : SHNSAS Shinryo to Shinyaku. Medical Consultation and New Remedies. (Iji Shuppan Sha, 1-2-8 Shinkawa, Chuo-Ku, Tokyo 104, Japan) V.1- 1964- Volume(issue)/page/year: 11,2533,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 520 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold REFERENCE : SHNSAS Shinryo to Shinyaku. Medical Consultation and New Remedies. (Iji Shuppan Sha, 1-2-8 Shinkawa, Chuo-Ku, Tokyo 104, Japan) V.1- 1964- Volume(issue)/page/year: 11,2533,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1540 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,615,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 105 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - ataxia REFERENCE : SHNSAS Shinryo to Shinyaku. Medical Consultation and New Remedies. (Iji Shuppan Sha, 1-2-8 Shinkawa, Chuo-Ku, Tokyo 104, Japan) V.1- 1964- Volume(issue)/page/year: 11,2533,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 145 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold REFERENCE : SHNSAS Shinryo to Shinyaku. Medical Consultation and New Remedies. (Iji Shuppan Sha, 1-2-8 Shinkawa, Chuo-Ku, Tokyo 104, Japan) V.1- 1964- Volume(issue)/page/year: 11,2533,1974

安全

• RTECS号: CO4826000
• 海关编码: 2904100000

合成路线

489-84-9 ~% 6223-35-4

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 19 p. 5722 - 5725

16915-32-5 ~% 6223-35-4

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 19 p. 5722 - 5725

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海关

海关编码	2904100000
中文概述	2904100000 仅含磺基的衍生物及其盐和乙酯。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2904100000 derivatives containing only sulpho groups, their salts and ethyl esters。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%