1668-99-1

• 常用中文名：奎尼定盐酸盐
• 常用英文名：(9S)-6'-methoxycinchonan-9-ol monohydrochloride
• CAS号：1668-99-1
• 分子式：C₂₀H₂₅ClN₂O₂
• 分子量：360.87800
• 发布时间：2018-02-13 08:00:00
• 更新时间：2024-04-07 12:44:04

名称

• 中文名: 奎尼定盐酸盐
• 英文名: (S)-[(2R,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol,hydrochloride
• 英文别名: Quinidine,monohydrochloride; EINECS 216-792-8; Chinidin hydrochlorid

物化性质

• 沸点: 495.9ºC at 760mmHg
• 分子式: C₂₀H₂₅ClN₂O₂
• 分子量: 360.87800
• 闪点: 253.7ºC
• 精确质量: 360.16000
• PSA: 45.59000
• LogP: 3.91310
• 蒸汽压: 1.19E-10mmHg at 25°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VA5750000 CHEMICAL NAME : Quinidine, monohydrochloride CAS REGISTRY NUMBER : 1668-99-1 LAST UPDATED : 199506 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C20-H24-N2-O2.Cl-H HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 263 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,589,1977 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 52,2797,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,589,1977 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >125 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 52,2797,1992 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 600 mg/kg/4D-I TOXIC EFFECTS : Kidney, Ureter, Bladder - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) REFERENCE : FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 33,203,1995