查看所有供应商和价格请点击：
| 中文名 | 奎寧定鹽酸鹽 |
|---|---|
| 英文名 | quinidine hydrochloride |
| 中文别名 | 奎尼丁 盐酸盐 一水合物 |
| 英文别名 |
Quinidine monohydrate hydrochloride
QUINIDINE HYDROCHLORIDE MONOHYDRATE |
| 描述 | Quinidine hydrochloride monohydrate 是临床抗心律失常药物,也是 K+ 通道 (K+ channel) 的有效阻断剂,其 IC50 值为 19.9 μM。 |
|---|---|
| 相关类别 | |
| 靶点 |
IC50: 19.9 μM (K+ channel)[1] |
| 体外研究 | 盐酸奎尼丁一水合物阻断WT mSlo3(KCa5.1)通道,IC50为19.9±1.41μM,Hill斜率为1.15±0.15(n = 7)。同样,盐酸奎尼丁一水合物的抑制效力高于F304Y mSlo3(IC50为2.42±0.60μM,n = 9,P <0.005; Hill斜率为0.98±0.12),但R196Q mSlo3较低(IC50为38.4±6.77) μM,n = 5,P <0.001;山坡为1.05±0.16)。观察到奎尼定盐酸盐一水合物对F304Y mSlo3的抑制作用具有一定的时间依赖性[1]。 |
| 体内研究 | 当比较基线与其他时间点或比较实验时,盐酸奎尼丁一水合物直接应用于坐骨神经,在上升的躯体感觉诱发电位(SSEP)和下降的复合肌肉动作电位(CMAP)中产生剂量相关的幅度减小。左肢到右侧对侧经葡萄糖治疗的肢体。与基线和对侧相比,盐酸奎尼丁一水合物应用后SSEPs和CMAP电位的潜伏期增加[2]。 |
| 细胞实验 | 小鼠（m）Slo3（KCa5.1）通道或突变形式在爪蟾卵母细胞中表达，并用2电极电压钳记录电流。增益功能mSlo3突变用于探索抑制的状态依赖性。盐酸奎尼丁一水合物和mSlo3通道之间的相互作用通过计算机对接模拟[1]。 |
| 动物实验 | 将24只大鼠随机分成3组，每组8只。组Q1，Q3和Q5分别在5％葡萄糖0.1mL中接受1,3和5μmol奎尼丁盐酸盐一水合物。通过从左侧坐骨切口到大腿远端切开来暴露坐骨神经。直接切开皮下组织以暴露股二头肌。坐骨神经从其投资筋膜中解脱出来。然后在右侧重复该过程。在基线时，在奎尼丁盐酸盐一水合物处理后立即记录躯体感觉诱发电位（SSEP）和复合肌肉动作电位（CMAP），然后每15分钟记录1小时，然后每30分钟记录3小时。允许动物恢复，然后分开保存2周。在进行行为检查后，在腹膜内麻醉下对动物进行电生理检查[2]。 |
| 参考文献 |
| 沸点 | 495.9ºC at 760 mmHg |
|---|---|
| 熔点 | 258-259ºC |
| 分子式 | C20H27ClN2O3 |
| 分子量 | 378.89300 |
| 闪点 | 253.7ºC |
| 精确质量 | 378.17100 |
| PSA | 54.82000 |
| LogP | 3.84880 |
| 储存条件 | 2-8℃ |
|
Section 1. Chemical Product and Company Identification Quinidine HCl monohydrateCatalog QU104 Common Name/ Number(s). Trade Name CAS#6151-40-2
Manufacturer RTECSVA5750000 SPECTRUM CHEMICAL MFG. CORP. TSCATSCA 8(b) inventory: Quinidine HCl monohydrate Commercial Name(s)Not available. CI# Not available. Synonym6'-Methoxycinchonan-9-ol hydrochloride IN CASE OF EMERGENCY Not available. Chemical Name Chemical FamilyNot available.CALL (310) 516-8000 C20H24N2O2.HCl.H2O Chemical Formula SPECTRUM CHEMICAL MFG. CORP. Section 2.Composition and Information on Ingredients Exposure Limits TWA (mg/m3)STEL (mg/m3) CEIL (mg/m3) NameCAS #% by Weight 1) Quinidine HCl monohydrate6151-40-2100 Toxicological DataQuinidine HCl monohydrate on IngredientsLD50: Not available. LC50: Not available. Section 3. Hazards Identification Potential Acute Health Effects Very hazardous in case of ingestion. Hazardous in case of eye contact (irritant), of inhalation. Potential Chronic HealthVery hazardous in case of ingestion. EffectsHazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. Quinidine HCl monohydrate Section 4. First Aid Measures Eye ContactCheck for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used. Do not use an eye ointment. Seek medical attention. Skin ContactNo known effect on skin contact, rinse with water for a few minutes. Serious Skin ContactNot available. InhalationAllow the victim to rest in a well ventilated area. Seek immediate medical attention. Serious InhalationNot available. IngestionDo not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature Not available. Flash PointsNot available. Flammable LimitsNot available. Products of CombustionThese products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated compounds. Fire Hazards in Presence of Not available. Various Substances Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available. of Various SubstancesRisks of explosion of the product in presence of static discharge: Not available. Fire Fighting MediaSMALL FIRE: Use DRY chemical powder. and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks onNot available. Fire Hazards Special Remarks on Explosion Not available. Hazards Section 6. Accidental Release Measures Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large SpillUse a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Quinidine HCl monohydrate Section 7. Handling and Storage PrecautionsKeep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not breathe dust. Avoid contact with eyes Wear suitable protective clothing In case of insufficient ventilation, wear suitable respiratory equipment If you feel unwell, seek medical attention and show the label when possible. StorageKeep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly closed. Keep in a cool, well-ventilated place. Combustible materials should be stored away from extreme heat and away from strong oxidizing agents. Section 8. Exposure Controls/Personal Protection Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSplash goggles. Lab coat. Personal Protection in Case of Splash goggles. Full suit. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a a Large Spillspecialist BEFORE handling this product. Exposure LimitsNot available. Section 9. Physical and Chemical Properties Physical state and appearance Solid. (Crystals solid.)OdorOdorless. TasteBitter. Molecular Weight378.9 g/mole ColorWhite. pH (1% soln/water)Not available. Not available. Boiling Point Melting PointDecomposes. (259°C or 498.2°F) Not available. Critical Temperature Specific GravityNot available. Vapor PressureNot applicable. Vapor DensityNot available. VolatilityNot available. Odor ThresholdNot available. Water/Oil Dist. Coeff.Not available. Ionicity (in Water)Not available. Dispersion PropertiesSee solubility in water, methanol. SolubilitySoluble in methanol. Partially soluble in cold water. Section 10. Stability and Reactivity Data StabilityThe product is stable. Not available. Instability Temperature Conditions of InstabilityNot available. Incompatibility with various Not available. substances Quinidine HCl monohydrate CorrosivityNon-corrosive in presence of glass. Special Remarks onNot available. Reactivity Special Remarks onNot available. Corrosivity PolymerizationNo. Section 11. Toxicological Information Routes of EntryEye contact. Inhalation. Ingestion. Toxicity to AnimalsLD50: Not available. LC50: Not available. Chronic Effects on Humans Not available. Other Toxic Effects onVery hazardous in case of ingestion. HumansHazardous in case of inhalation. Special Remarks onNot available. Toxicity to Animals Special Remarks onHuman: passes through the placenta, excreted in maternal milk. Chronic Effects on Humans Special Remarks on otherNot available. Toxic Effects on Humans Section 12. Ecological Information EcotoxicityNot available. BOD5 and CODNot available. Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the ProductsThe products of degradation are more toxic. of Biodegradation Special Remarks on theNot available. Products of Biodegradation Section 13. Disposal Considerations Waste Disposal Section 14. Transport Information DOT ClassificationNot a DOT controlled material (United States). IdentificationNot applicable. Special Provisions forNot applicable. Transport Quinidine HCl monohydrate DOT (Pictograms) Section 15. Other Regulatory Information and Pictograms TSCA 8(b) inventory: Quinidine HCl monohydrate Federal and State Regulations California Proposition 65 Warnings Other RegulationsNot available.. WHMIS (Canada) Not controlled under WHMIS (Canada). Other Classifications DSCL (EEC)R36- Irritating to eyes. Health Hazard HMIS (U.S.A.)2 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 2 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection j WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG (Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Not applicable. Lab coat. Not applicable. Splash goggles. SECTION 16 - ADDITIONAL INFORMATION N/A |
| 符号 |
GHS07 |
|---|---|
| 信号词 | Warning |
| 危害声明 | H302-H312-H332 |
| 警示性声明 | P280 |
| 个人防护装备 | dust mask type N95 (US);Eyeshields;Gloves |
| 危害码 (欧洲) | Xn,Xi |
| 风险声明 (欧洲) | 20/21/22-36/37/38 |
| 安全声明 (欧洲) | 36-26 |
| 危险品运输编码 | UN 2811 6.1/PG 3 |