24159-07-7

• 常用中文名：常山乙素
• 常用英文名：Febrifugine
• CAS号：24159-07-7
• 分子式：C₁₆H₁₉N₃O₃
• 分子量：301.340
• 相关类别： 生物化工 中草药成分
• 发布时间：2018-06-20 11:28:28
• 更新时间：2024-01-02 11:31:19
• Febrifugine 是存在于常山的根和叶中的一种喹唑啉酮类生物碱,具有抗疟活性。

名称

• 中文名: 常山乙素
• 英文名: Febrifugine
• 中文别名: 3-[3-[(2R,3S)-3-羟基-2-哌啶基]-2-氧代丙基]-4(3H)-喹唑啉酮; Β-常山碱; 常山碱
• 英文别名: 3-{3-[(2S,3R)-3-Hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one; 3-[b-Keto-g-(3-hydroxy-2-piperidyl)propyl]-4-quinazolone; (2S-trans)-3-[3-(3-Hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone; 3-{3-[(2S,3R)-3-Hydroxy-2-piperidinyl]-2-oxopropyl}-4(3H)-quinazolinone; b-Dichroine; β-Dichroine; 4(3H)-Quinazolinone, 3-[3-[(2S,3R)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-; Febrifugine; febrifungine; Febrifugine (8CI)

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 508.2±60.0 °C at 760 mmHg
• 熔点: 139-140°; mp 154-156°
• 分子式: C₁₆H₁₉N₃O₃
• 分子量: 301.340
• 闪点: 261.1±32.9 °C
• 精确质量: 301.142639
• PSA: 84.22000
• LogP: -0.04
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.673
• 储存条件: 2-8℃

生物活性

• 描述: Febrifugine 是存在于常山的根和叶中的一种喹唑啉酮类生物碱,具有抗疟活性。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Herman JD, et al. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Sci Transl Med. 2015 May 20;7(288):288ra77.

  [2]. McLaughlin NP, et al. The chemistry and biology of febrifugine and halofuginone. Bioorg Med Chem. 2014 Apr 1;22(7):1993-2004.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VA3450000 CHEMICAL NAME : 4(3H)-Quinazolinone, 3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, (2S-trans)- CAS REGISTRY NUMBER : 24159-07-7 LAST UPDATED : 199707 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C16-H19-N3-O3 MOLECULAR WEIGHT : 301.38 WISWESSER LINE NOTATION : T66 BVN ENJ C1V1- BT6NTJ CQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 71,1048,1949 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,867,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4600 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 161,400,1948

安全

• 海关编码: 2933990090

合成路线

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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%