480449-70-5

• 常用中文名：艾多沙班
• 常用英文名：edoxaban
• CAS号：480449-70-5
• 分子式：C₂₄H₃₀ClN₇O₄S
• 分子量：548.057
• 相关类别： 信号通路 代谢酶/蛋白酶 因子Xa
• 发布时间：2018-06-12 10:43:14
• 更新时间：2024-01-02 13:47:08
• Edoxaban(DU-176)是口服的FXa抑制剂,临床开发用于中风预防。

名称

• 中文名: 伊多塞班
• 英文名: edoxaban
• 中文别名: N-(5-氯-2-吡啶基)-N'-[(1S,2R,4S)-4-[(二甲基氨基)甲酰基]-2-[[(4,5,6,7-四氢-5-甲基噻唑并[5,4-c]吡啶-2-基)甲酰]氨基]环己基]乙二酰胺; 艾多沙班
• 英文别名: Ethanediamide, N-(5-chloro-2-pyridinyl)-N-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-; N-(5-Chloro-2-pyridinyl)-N'-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]ethanediamide; Edoxaban; Lixiana; Savaysa; EthanediaMide,N1-(5-chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(diMethylaMino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-Methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]aMino]cyclohexyl]; EthanediaMide,N1-(5-chlo...; N-(5-Chloro-2-pyridinyl)-N'-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-{[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbonyl]amino}cyclohexyl]ethanediamide

物化性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₂₄H₃₀ClN₇O₄S
• 分子量: 548.057
• 精确质量: 547.176880
• PSA: 164.87000
• LogP: 1.24
• 折射率: 1.646
• 储存条件: 2-8°C

生物活性

• 描述: Edoxaban(DU-176)是口服的FXa抑制剂,临床开发用于中风预防。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 因子Xa
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Mendell J, Lee F, Chen S, The Effects of the Antiplatelet Agents, Aspirin and Naproxen, on Pharmacokinetics and Pharmacodynamics of the Anticoagulant Edoxaban, a Direct Factor Xa Inhibitor. J Cardiovasc Pharmacol. 2013 Apr 23. [Epub ahead of print]

  [2]. Mendell J, Noveck RJ, Shi M. Pharmacokinetics of the direct factor Xa inhibitor edoxaban and digoxin administered alone and in combination. J Cardiovasc Pharmacol. 2012 Oct;60(4):335-41.

  [3]. Bathala MS, Masumoto H, Oguma T, Pharmacokinetics, biotransformation, and mass balance of edoxaban, a selective, direct factor Xa inhibitor, in humans. Drug Metab Dispos. 2012 Dec;40(12):2250-5.

安全

• 危害码 (欧洲): Xn
• 海关编码: 2934999090

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%