29462-18-8

• 常用中文名：苯他西泮
• 常用英文名：Bentazepam
• CAS号：29462-18-8
• 分子式：C₁₇H₁₆N₂OS
• 分子量：296.38700
• 相关类别： 研究领域 神经疾病
• 发布时间：2018-08-26 07:59:15
• 更新时间：2024-01-07 15:21:06
• 苯他西泮(噻吩)是一种具有短效抗焦虑作用的化合物。苯他西泮具有抗惊厥和镇静作用。苯他西泮可用于抑郁症和焦虑症的研究[1]。

名称

• 中文名: 苯他西泮
• 英文名: 5-phenyl-3,4,6,7,8,9-hexahydro-[1]benzothiolo[2,3-e][1,4]diazepin-2-one
• 英文别名: Bentazepam; CI-718; Tiadipone; Thiadipone; 1,3,6,7,8,9-Hexahydro-5-phenyl-2H-(1)benzothieno(2,3-e)-1,4-diazepin-2-one; QM-6008; 5-phenyl-1,3,6,7,8,9-hexahydro-benzo[4,5]thieno[2,3-e][1,4]diazepin-2-one; Bentazepamum [INN-Latin]; 2H-(1)BENZOTHIENO(2,3-e)-1,4-DIAZEPIN-2-ONE,1,3,6,7,8,9-HEXAHYDRO-5-PHENYL

物化性质

• 密度: 1.38g/cm3
• 沸点: 532.6ºC at 760 mmHg
• 分子式: C₁₇H₁₆N₂OS
• 分子量: 296.38700
• 闪点: 275.9ºC
• 精确质量: 296.09800
• PSA: 69.70000
• LogP: 2.99000
• 蒸汽压: 2E-11mmHg at 25°C
• 折射率: 1.733
• 储存条件: 通风低温干燥

生物活性

• 描述: 苯他西泮(噻吩)是一种具有短效抗焦虑作用的化合物。苯他西泮具有抗惊厥和镇静作用。苯他西泮可用于抑郁症和焦虑症的研究[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 体内研究: 苯他西泮增加氯硝西泮的抗惊厥活性[1]。

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DL8230000 CHEMICAL NAME : 2H-(1)Benzothieno(2,3-e)-1,4-diazepin-2-one, 1,3,6,7,8,9-hexahydro-5-phenyl- CAS REGISTRY NUMBER : 29462-18-8 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C17-H16-N2-O-S MOLECULAR WEIGHT : 296.41 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 129 mg/kg/17W-I TOXIC EFFECTS : Behavioral - anorexia (human) Behavioral - muscle weakness Liver - liver function tests impaired REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 343,860,1994 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,926,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 980 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,926,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 630 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,926,1975

合成路线

29462-27-9 ~% 29462-18-8

文献：Tinney; Sanchez; Nogas Journal of Medicinal Chemistry, 1974 , vol. 17, # 6 p. 624 - 630

41042-86-8 ~% 29462-18-8

文献：Nakanishi,M. et al. Journal of Medicinal Chemistry, 1973 , vol. 16, p. 214 - 219

43215-25-4 623-33-6 ~% 29462-18-8

文献：Heckendorn; Gagneux Tetrahedron Letters, 1973 , vol. 25, p. 2279 - 2282

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