1464-33-1

• 常用中文名：5-羟基-4-甲氧甲基-6-甲基-3-吡啶甲醇
• 常用英文名：Ginkgotoxin
• CAS号：1464-33-1
• 分子式：C₉H₁₃NO₃
• 分子量：183.204
• 相关类别： 医药中间体 杂环化合物 吡啶类化合物 羟基吡啶
• 发布时间：2018-12-29 20:05:51
• 更新时间：2024-01-21 15:29:40
• 4'-O-甲基吡哆醇是一种天然化合物,具有抗氧化活性[1]。

名称

• 中文名: 3-羟基-5-羟甲基-4-甲氧甲基-2-甲基吡啶
• 英文名: 5-(hydroxymethyl)-4-(methoxymethyl)-2-methylpyridin-3-ol
• 中文别名: 5-羟基-4-甲氧甲基-6-甲基-3-吡啶甲醇; 3-羟基-5-羟基甲基-4-甲氧基甲基-2-甲基吡啶
• 英文别名: 3-Pyridinemethanol, 5-hydroxy-4-(methoxymethyl)-6-methyl-; 4-Methoxypyridoxine; 4-Methoxymethylpyridoxine; 5-(Hydroxymethyl)-4-(methoxymethyl)-2-methyl-3-pyridinol; 4'-O-methyl pyridoxine; 5-hydroxymethyl-4-methoxymethyl-2-methyl-pyridin-3-ol; 4'-O-methyl pyridoxime; 5-Hydroxy-4-(methoxymethyl)-6-methyl-3-pyridinemethanol; Ginkgotoxin; 3-Pyridinemethanol,5-hydroxy-4-(methoxymethyl)-6-methyl; 3-HYDROXY-5-HYDROXYMETHYL-4-METHOXYMETHYL-2-METHYLPYRIDINE

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 404.2±40.0 °C at 760 mmHg
• 熔点: 181°C
• 分子式: C₉H₁₃NO₃
• 分子量: 183.204
• 闪点: 198.3±27.3 °C
• 精确质量: 183.089539
• PSA: 62.58000
• LogP: -0.68
• 外观性状: 固体
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.562
• 储存条件: 室温， 密封， 干燥

生物活性

• 描述: 4'-O-甲基吡哆醇是一种天然化合物,具有抗氧化活性[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Isaac Duah Boateng, et al. Effect of different drying methods on product quality, bioactive and toxic components of Ginkgo biloba L. seed. J Sci Food Agric. 2021 Jun;101(8):3290-3297.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UT5009000 CHEMICAL NAME : 3-Pyridinemethanol, 5-hydroxy-4-(methoxymethyl)-6-methyl- CAS REGISTRY NUMBER : 1464-33-1 BEILSTEIN REFERENCE NO. : 0150788 LAST UPDATED : 199612 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C9-H13-N-O3 MOLECULAR WEIGHT : 183.23 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 540 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea REFERENCE : PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 4,179,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 32 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 4,179,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 23 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 4,179,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 4,179,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 8 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression REFERENCE : PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 4,179,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 9 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression REFERENCE : PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 4,179,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 17 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression REFERENCE : PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 4,179,1964

安全

• 符号: GHS06
• 信号词: Danger
• 危害声明: H300 + H330
• 警示性声明: P260-P284-P301 + P310 + P330-P304 + P340 + P310-P403 + P233
• 危害码 (欧洲): Xi
• 危险品运输编码: UN 1544PSN1 6.1 / PGII
• RTECS号: UT5009000
• 海关编码: 2933399090

合成路线

67-56-1 65-23-6 ~15% 1464-33-1

文献：Brousmiche, Darryl; Wan, Peter Chemical Communications, 1998 , # 4 p. 491 - 492

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海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%