930-37-0

• 常用中文名：(甲氧基甲基)环氧乙烷
• 常用英文名：Glycidyl Methyl Ether
• CAS号：930-37-0
• 分子式：C₄H₈O₂
• 分子量：88.105
• 相关类别： 有机原料 烃类化合物及其衍生物 芳香烃
• 发布时间：2018-04-06 08:00:00
• 更新时间：2024-01-02 23:28:33

名称

• 中文名: 环氧丙基甲基醚
• 英文名: Glycidyl Methyl Ether
• 中文别名: 2,3-环氧丙烷甲基醚; (甲氧基甲基)环氧乙烷; 1,2-环氧-3-甲氧基丙烷; 2,3-环氧丙基甲基醚; 甲基缩水甘油醚
• 英文别名: (Methoxymethyl)oxirane; 3-Methoxypropylene oxide; Oxirane, (methoxymethyl)-; Methyl-(2,3-epoxypropyl) Ether; 2-(Methoxymethyl)oxirane; Methyl glycidyl ether; Epimethylin; Oxirane, 2-(methoxymethyl)-; Glycidyl Methyl Ether; Propane, 1,2-epoxy-3-methoxy-; 1,2-Epoxy-3-methoxypropane; 3-Methoxy-1,2-epoxypropane; EINECS 213-216-7; 2,3-Epoxypropyl methyl ether

物化性质

• 密度: 0.9807 g/cm3 (20 ºC)
• 沸点: 113 ºC (760 Torr)
• 分子式: C₄H₈O₂
• 分子量: 88.105
• 闪点: 8.1±3.4 °C
• 精确质量: 88.052429
• PSA: 21.76000
• LogP: -0.17
• 蒸汽压: 21.6±0.2 mmHg at 25°C
• 折射率: 1.411
• 储存条件: 室温，干燥
• 分子结构:

  1、 摩尔折射率：21.90

  2、 摩尔体积（m³/mol）：88.2

  3、 等张比容（90.2K）：208.4

  4、 表面张力（dyne/cm）：31.1

  5、 极化率（10 ^-24cm ³）：9.68

• 计算化学:

  1.疏水参数计算参考值（XlogP）:-0.2

  2.氢键供体数量:0

  3.氢键受体数量:2

  4.可旋转化学键数量:2

  5.互变异构体数量:无

  6.拓扑分子极性表面积21.8

  7.重原子数量:6

  8.表面电荷:0

  9.复杂度:44.8

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:1

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：未确定

  2. 密度（g/mL,25/4℃）：0,98 g/cm³

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：未确定

  5. 沸点（ºC,常压）：110°C

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：24°C

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：未确定

MSDS

Glycidyl Methyl Ether SAFETY DATA SHEET Section1. IDENTIFICATION Product name:Glycidyl Methyl Ether Section2. HAZARDS IDENTIFICATION GHS classification PHYSICAL HAZARDS Category 3 Flammable liquids HEALTH HAZARDS Category 4 Acute toxicity (Oral) Acute toxicity (Dermal)Category 3 Category 2 Skin corrosion/irritation Serious eye damage/eye irritationCategory 2A Not classified ENVIRONMENTAL HAZARDS GHS label elements, including precautionary statements Pictograms or hazard symbols Signal wordDanger Flammable liquid and vapour Hazard statements Harmful if swallowed Toxic in contact with skin Causes skin irritation Causes serious eye irritation Precautionary statements: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. [Prevention] Keep container tightly closed. Use explosion-proof electrical/ventilating/lighting equipment. Take precautionary measures against ignition by the static discharge and the spark. Do not eat, drink or smoke when using this product. Wash hands thoroughly after handling. Wear protective gloves and eye/face protection. Glycidyl Methyl Ether Section2. HAZARDS IDENTIFICATION [Response]IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. If skin irritation occurs: Get medical advice/attention. Remove/Take off immediately all contaminated clothing. Wash contaminated clothing before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. [Storage]Store in a well-ventilated place. Keep cool. Store locked up. [Disposal]Dispose of contents/container through a waste management company authorized by the local government. Section3. COMPOSITION/INFORMATION ON INGREDIENTS Substance/mixture:Substance Glycidyl Methyl Ether Components: Percent:>85.0%(GC) CAS Number:930-37-0 Synonyms:1,2-Epoxy-3-methoxypropane Chemical Formula:C4H8O2 Section4. FIRST AID MEASURES Remove victim to fresh air and keep at rest in a position comfortable for breathing. Inhalation: Call a POISON CENTER or doctor/physician if you feel unwell. Skin contact:Remove/Take off immediately all contaminated clothing. Gently wash with plenty of soap and water. Call a POISON CENTER or doctor/physician. Eye contact:Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. Ingestion:Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. Protection of first-aiders:A rescuer should wear personal protective equipment, such as rubber gloves and air- tight goggles. Section5. FIRE-FIGHTING MEASURES Suitable extinguishingDry chemical, foam, water in large amounts, carbon dioxide. media: Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place. In case of fire in the surroundings: Keep containers cool by spraying with water. Eliminate all ignition sources if safe to do so. Special protectiveWhen extinguishing fire, be sure to wear personal protective equipment. equipment for firefighters: Section6. ACCIDENTAL RELEASE MEASURES Use extra personal protective equipment (self-contained breathing apparatus). Keep Personal precautions, protective equipment and people away from and upwind of spill/leak. Ensure adequate ventilation. Entry to non- emergency procedures: involved personnel should be controlled around the leakage area by roping off, etc. Environmental precautions: Prevent product from entering drains. Methods and materials for Absorb spilled material in dry sand or inert absorbent before recovering it into an containment and cleaning airtight container. In case of large amount of spillage, contain a spill by bunding. up: Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations. Glycidyl Methyl Ether Section6. ACCIDENTAL RELEASE MEASURES Prevention of secondary Remove all sources of ignition. Fire-extinguishing devices should be prepared in hazards:case of a fire. Use spark-proof tools and explosion-proof equipment. Section7. HANDLING AND STORAGE Precautions for safe handling Technical measures:Handling is performed in a well ventilated place. Wear suitable protective equipment. Prevent generation of vapour or mist. Keep away from heat/sparks/open flame/hot surfaces. -No smoking. Take measures to prevent the build up of electrostatic charge. Use explosion-proof equipment. Wash hands and face thoroughly after handling. Use a closed system if possible. Use a ventilation, local exhaust if vapour or aerosol will be generated. Advice on safe handling: Avoid contact with skin, eyes and clothing. Conditions for safe storage, including any incompatibilities Storage conditions:Keep container tightly closed. Store in a cool, dark and well-ventilated place. Store locked up. Store away from incompatible materials such as oxidizing agents. Comply with laws. Packaging material: Section8. EXPOSURE CONTROLS / PERSONAL PROTECTION Engineering controls:Install a closed system or local exhaust. Also install safety shower and eye bath. Personal protective equipment Respiratory protection: Half or full facepiece respirator, self-contained breathing apparatus(SCBA), supplied air respirator, etc. Use respirators approved under appropriate government standards and follow local and national regulations. Impervious gloves. Hand protection: Eye protection:Safety goggles. A face-shield, if the situation requires. Skin and body protection: Impervious protective clothing. Protective boots, if the situation requires. Section9. PHYSICAL AND CHEMICAL PROPERTIES Physical state (20°C):Liquid Form:Clear Colorless - Very pale yellow Colour: Odour:Pungent pH: No data available Melting point/freezing point:No data available Boiling point/range:110°C Flash point:25°C Flammability or explosive limits: Lower:No data available Upper:No data available Relative density:0.99 Solubility(ies): [Water]Miscible [Other solvents] Soluble:Methanol, Ethanol Log Pow:-0.17 Section10. STABILITY AND REACTIVITY Chemical stability:Stable under proper conditions. Possibility of hazardous No special reactivity has been reported. reactions: Spark, Open flame, Static discharge Conditions to avoid: Incompatible materials: Oxidizing agents, Acids, Bases Glycidyl Methyl Ether Section10. STABILITY AND REACTIVITY Hazardous decomposition Carbon monoxide, Carbon dioxide products: Section11. TOXICOLOGICAL INFORMATION Acute Toxicity:orl-rat LD50:467 uL/kg skn-rbt LD50:707 uL/kg Skin corrosion/irritation: skn-rbt 500 uL/24H SEV Serious eyeeye-rbt 10 uL MOD damage/irritation: Germ cell mutagenicity: mmo-klp 200 umol/L (-S9) mmo-sat 100 ug/plate (+S9) Carcinogenicity: IARC =No data available NTP =No data available Reproductive toxicity:No data available RTECS Number:TZ3530000 Section12. ECOLOGICAL INFORMATION Ecotoxicity: Fish:No data available No data available Crustacea: Algae:No data available Persistence / degradability: No data available Bioaccumulative1.0 potential(BCF): Mobility in soil -0.17 Log Pow: Soil adsorption (Koc):19.3 No data available Henry's Law constant(PaM3/mol): Section13. DISPOSAL CONSIDERATIONS Recycle to process, if possible. Consult your local regional authorities. You may be able to burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when disposing of the substance. Section14. TRANSPORT INFORMATION 3: Flammable liquid. Hazards Class: Subsidiary risk:6.1: Toxic substance. 1992 UN-No: Proper shipping name:Flammable liquid, toxic, n.o.s. Packing group:III Section15. REGULATORY INFORMATION Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002 and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport, loading and unloading were prescribed. Glycidyl Methyl Ether SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 急性毒性：大鼠口经LD50：467uL/kg CHEMICAL IDENTIFICATION RTECS NUMBER : TZ3530000 CHEMICAL NAME : Propane, 1,2-epoxy-3-methoxy- CAS REGISTRY NUMBER : 930-37-0 BEILSTEIN REFERENCE NO. : 0102505 LAST UPDATED : 199806 DATA ITEMS CITED : 12 MOLECULAR FORMULA : C4-H8-O2 MOLECULAR WEIGHT : 88.12 WISWESSER LINE NOTATION : T3OTJ B1O1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 467 uL/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 707 uL/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Skin and Appendages - dermatitis, other (after systemic exposure) MUTATION DATA TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 1250 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 249,55,1991

安全

• 危害码 (欧洲): F+
• 风险声明 (欧洲): 10
• 安全声明 (欧洲): S16
• 危险品运输编码: UN 3271
• RTECS号: TZ3530000
• 包装等级: II
• 危险类别: 3.1
• 海关编码: 2910900090

合成路线

4151-97-7 ~90% 930-37-0

文献：Dishong, Dennis M.; Diamond, Craig J.; Cinoman, Michael I.; Gokel, Geoge W. Journal of the American Chemical Society, 1983 , vol. 105, # 3 p. 586 - 593

106-89-8 ~% 930-37-0

文献：US6194409 B1, ;

67-56-1 3132-64-7 ~% 930-37-0

文献：Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 1132 - 1137

67-56-1 106-89-8 ~% 930-37-0

文献：Pharmaceutical Chemistry Journal, , vol. 25, # 7 p. 492 - 495 Khimiko-Farmatsevticheskii Zhurnal, , vol. 25, # 7 p. 51 - 54

124-41-4 106-89-8 ~% 930-37-0

文献：Journal of Medicinal Chemistry, , vol. 23, # 6 p. 620 - 624

142-28-9 627-30-5 ~% 930-37-0 1436-34-6 详细

文献：WO2009/773 A1, ; Page/Page column 19-21 ;

627-40-7 ~% 930-37-0

文献：Agricultural and Biological Chemistry, , vol. 52, # 11 p. 2911 - 2918

26438-92-6 ~% 930-37-0

文献：Recueil des Travaux Chimiques des Pays-Bas, , vol. 23, p. 351 Chem. Zentralbl., , vol. 75, # II p. 302

上下游产品

上游产品  9
4151-97-7 106-89-8 67-56-1 3132-64-7
124-41-4 142-28-9 627-30-5 627-40-7
26438-92-6
下游产品  10
19858-14-1 26072-85-5 5878-19-3 2806-84-0
86195-49-5 71484-94-1 64491-68-5 64491-70-9
1000801-77-3 107-98-2

海关

海关编码	2910900090
中文概述	2910900090. 三节环环氧化物，环氧醇（酚，醚），包括其卤化，磺化，硝化或亚硝化的衍生物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2910900090. epoxides, epoxyalcohols, epoxyphenols and epoxyethers, with a three-membered ring, and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%