60084-10-8

• 常用中文名：噻唑呋林
• 常用英文名：Tiazofurin
• CAS号：60084-10-8
• 分子式：C₉H₁₂N₂O₅S
• 分子量：260.267
• 相关类别： 信号通路 细胞周期/DNA损伤 核苷抗代谢药/类似物
• 发布时间：2018-04-14 08:00:00
• 更新时间：2024-01-08 15:56:21
• 硫唑呋林是一种具有抗肿瘤活性的合成核苷类似物。噻唑呋林在细胞内合成代谢为噻唑-4-甲酰胺腺嘌呤二核苷酸(TAD),一种IMP脱氢酶(IMPDH)的有效抑制剂。

名称

• 中文名: 噻唑呋林
• 英文名: 2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-thiazole-4-carboxamide
• 英文别名: (1R)-1,4-Anhydro-1-(4-carbamoyl-1,3-thiazol-2-yl)-D-ribitol; Riboxamide; D-Ribitol, 1-C-[4-(aminocarbonyl)-2-thiazolyl]-1,4-anhydro-, (1R)-; 2-b-D-Ribofuranosyl-4-thiazolecarboxamide; Tiazofurina [Spanish]; 4-Thiazolecarboxamide, 2-β-D-ribofuranosyl-; 2-β-D-Ribofuranosyl-4-thiazolecarboxamide; [3H]-Tiazofurin; Tiazofurine; Tiazole; Tiazofurin; Tiazofurina; Tiazofurinum; 2-β-D-Ribofuranosylthiazole-4-carboxamide; Tiazofurinum [Latin]

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 641.3±55.0 °C at 760 mmHg
• 分子式: C₉H₁₂N₂O₅S
• 分子量: 260.267
• 闪点: 341.6±31.5 °C
• 精确质量: 260.046692
• PSA: 154.14000
• LogP: -1.13
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.675
• 储存条件: 2-8°C，避光，惰性气体保存

生物活性

• 描述: 硫唑呋林是一种具有抗肿瘤活性的合成核苷类似物。噻唑呋林在细胞内合成代谢为噻唑-4-甲酰胺腺嘌呤二核苷酸(TAD),一种IMP脱氢酶(IMPDH)的有效抑制剂。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
• 参考文献:

  [1]. Tricot G, Jayaram HN, Weber G, Hoffman R. Tiazofurin: biological effects and clinical uses. Int J Cell Cloning. 1990;8(3):161-170.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : XJ3600000 CHEMICAL NAME : 4-Thiazolecarboxamide, 2-beta-D-ribofuranosyl- CAS REGISTRY NUMBER : 60084-10-8 LAST UPDATED : 199612 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C9-H12-N2-O5-S MOLECULAR WEIGHT : 260.29 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human DOSE/DURATION : 1135 mg/kg/15D-I TOXIC EFFECTS : Behavioral - headache Musculoskeletal - other changes TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human DOSE/DURATION : 892 mg/kg/10D-I TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1684 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3400 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Blood - other changes TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 1090 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Behavioral - fluid intake TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 3425 mg/kg SEX/DURATION : male 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct MUTATION DATA TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : 20 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 45,5512,1985

安全

• 危害码 (欧洲): Xi
• 海关编码: 2934100090

合成路线

上下游产品

上游产品  5
60084-09-5 95936-53-1 57944-10-2 23316-67-8
218145-21-2
下游产品  3
83285-83-0 92952-33-5 92952-40-4

海关

海关编码	2934100090
中文概述	2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%