160098-96-4

• 常用中文名：2-(2-呋喃基)-7-(2-苯基乙基)-7H-吡唑并[4,3-e][1,2,4]噻唑并[1,5-c]嘧啶-5-胺
• 常用英文名：SCH 58261
• CAS号：160098-96-4
• 分子式：C₁₈H₁₅N₇O
• 分子量：345.35800
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 腺苷受体
• 发布时间：2018-12-29 22:17:30
• 更新时间：2024-01-08 17:33:44
• SCH58261是adenosine A2A receptor竞争性的拮抗剂。

名称

• 中文名: 2-(2-呋喃基)-7-(2-苯基乙基)-7H-吡唑并[4,3-e][1,2,4]噻唑并[1,5-c]嘧啶-5-胺
• 英文名: 2-(2-furanyl)-7-(2-phenylethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
• 英文别名: 7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine; 2-(Furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine; SCH58261; SCH 58261

物化性质

• 密度: 1.54g/cm3
• 分子式: C₁₈H₁₅N₇O
• 分子量: 345.35800
• 精确质量: 345.13400
• PSA: 100.06000
• LogP: 3.14010
• 折射率: 1.807
• 储存条件: 2-8°C

生物活性

• 描述: SCH58261是adenosine A2A receptor竞争性的拮抗剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体
  研究领域 >> 癌症
• 参考文献:

  [1]. Paul A. Beavis et al. Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors. Proc Natl Acad Sci U S A, 2013 Sep 3, 110(36): 14711-14716.

  [2]. Alessia Melani et al. Time-course of protection by the selective A2Areceptor antagonist SCH58261 after transient focal cerebral ischemia. Neurological Sciences, August 2015, Volume 36, Issue 8, pp 1441-1448.

  [3]. Varani K et al. Pharmacological and biochemical characterization of purified A2a adenosine receptors in human platelet membranes by [3H]-CGS 21680 binding. Br J Pharmacol, 1996 Apr;117(8):1693-701.

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2934999090

合成路线

420-04-2 159979-95-0 ~20% 160098-96-4

文献：Baraldi, Pier Giovanni; Cacciari, Barbara; Spalluto, Giampiero; Pineda De Las Infantas Y Villatoro, Maria Jose; Zocchi, Cristina; Dionisotti, Silvio; Ongini, Ennio Journal of Medicinal Chemistry, 1996 , vol. 39, # 5 p. 1164 - 1171

3326-71-4 ~% 160098-96-4

文献：Baraldi, Pier Giovanni; Cacciari, Barbara; Spalluto, Giampiero; Pineda De Las Infantas Y Villatoro, Maria Jose; Zocchi, Cristina; Dionisotti, Silvio; Ongini, Ennio Journal of Medicinal Chemistry, 1996 , vol. 39, # 5 p. 1164 - 1171

162401-28-7 ~% 160098-96-4

文献：Baraldi, Pier Giovanni; Cacciari, Barbara; Spalluto, Giampiero; Pineda De Las Infantas Y Villatoro, Maria Jose; Zocchi, Cristina; Dionisotti, Silvio; Ongini, Ennio Journal of Medicinal Chemistry, 1996 , vol. 39, # 5 p. 1164 - 1171

159979-88-1 ~% 160098-96-4

文献：Baraldi, Pier Giovanni; Cacciari, Barbara; Spalluto, Giampiero; Pineda De Las Infantas Y Villatoro, Maria Jose; Zocchi, Cristina; Dionisotti, Silvio; Ongini, Ennio Journal of Medicinal Chemistry, 1996 , vol. 39, # 5 p. 1164 - 1171

上下游产品

上游产品  3
420-04-2 159979-95-0 3326-71-4
下游产品  0

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%