137-53-1

• 常用中文名：D-甲状腺素
• 常用英文名：D-THYROXINE SODIUM SALT
• CAS号：137-53-1
• 分子式：C₁₅H₁₀I₄NNaO₄
• 分子量：798.85200
• 相关类别： 原料药 激素及调节内分泌功能类药 甲状腺激素及抗甲状腺药
• 发布时间：2018-02-24 08:00:00
• 更新时间：2024-01-11 22:32:52
• D-甲状腺素(钠)(D-T4(钠))是甲状腺激素的左旋异构体,可用于研究甲状腺功能异常[1][2]。

名称

• 中文名: D-甲状腺素
• 英文名: d-thyroxine sodium salt
• 中文别名: 右甲状腺素钠
• 英文别名: detyroxin; biotirmone; Travenon; EINECS 205-301-2; dextroxin; lisolipin; choloxin; dextroid; dynothel; Eulipos; dethyrona

物化性质

• 沸点: 576.3ºC at 760mmHg
• 分子式: C₁₅H₁₀I₄NNaO₄
• 分子量: 798.85200
• 闪点: 302.3ºC
• 精确质量: 798.66900
• PSA: 95.61000
• LogP: 3.92290
• 蒸汽压: 4.02E-14mmHg at 25°C
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:2

  3.氢键受体数量:5

  4.可旋转化学键数量:5

  5.互变异构体数量:2

  6.拓扑分子极性表面积95.6

  7.重原子数量:25

  8.表面电荷:0

  9.复杂度:426

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:1

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:2

生物活性

• 描述: D-甲状腺素(钠)(D-T4(钠))是甲状腺激素的左旋异构体,可用于研究甲状腺功能异常[1][2]。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
• 体外研究: D-甲状腺素(钠)(D-T4(钠))也影响双羟基香豆素的药理作用[2]。
• 体内研究: D-甲状腺素(钠)(D-T4(钠))抑制小鼠体内双羟基香豆素以及哌替啶和戊巴比妥的代谢[1]。
• 参考文献:

  [1]. John J. Schrogie M.D., et al. II. The effect of D-thyroxine, clofibrate, and norethandrolone. Clinical Pharmacology and Therapeutics, Volume8, Issue1part1 January 1967 Pages 70-77

  [2]. Raluca-IoanaStefan, et al. Simultaneous determination of l-thyroxine (l-T4), d-thyroxine (d-T4), and l-triiodothyronine (l-T3) using a sensors/sequential injection analysis system.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : XP3582990 CHEMICAL NAME : Thyroxine, monosodium salt, D- CAS REGISTRY NUMBER : 137-53-1 LAST UPDATED : 199709 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C15-H10-I4-N-O4.Na MOLECULAR WEIGHT : 798.85 WISWESSER LINE NOTATION : QR BI FI DOR BI FI D1YZVO &-NA- HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 12 ug/kg/12D-I TOXIC EFFECTS : Liver - hepatitis (hepatocellular necrosis), diffuse Liver - liver function tests impaired Nutritional and Gross Metabolic - body temperature increase REFERENCE : JJMDAT Japanese Journal of Medicine. (Nankodo Co., Ltd., POB 5272, Tokyo International 100-31, Japan) V.1-30, 1962-1991. For publisher information, see IEDIEP. Volume(issue)/page/year: 23,282,1984 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1500 mg/kg/30D-C TOXIC EFFECTS : Vascular - BP elevation not characterized in autonomic section Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death REFERENCE : TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 29,207,1970 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 222 mg/kg/24W-C TOXIC EFFECTS : Vascular - BP elevation not characterized in autonomic section Kidney, Ureter, Bladder - changes in bladder weight Endocrine - evidence of thyroid hyperfunction REFERENCE : TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 29,565,1970 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 29 mg/kg SEX/DURATION : female 1-29 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 32,1182,1971 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 15 mg/kg SEX/DURATION : female 15-29 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - physical REFERENCE : DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 32,1182,1971 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 16 mg/kg SEX/DURATION : female 16-31 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system REFERENCE : SDMEAL South Dakota Journal of Medicine. (South Dakota Medical Assoc., 608 West Ave. N, Sioux Falls, SD 57104) V.18- 1965- Volume(issue)/page/year: 21,33,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5407 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 63 (estimated) No. of Female Employees: 9 (estimated)