D-THYROXINE SODIUM SALT

Modify Date: 2026-07-01 18:32:55

D-THYROXINE SODIUM SALT structure	Common Name	D-THYROXINE SODIUM SALT
	CAS Number	137-53-1	Molecular Weight	798.85200
	Density	N/A	Boiling Point	576.3ºC at 760mmHg
	Molecular Formula	C₁₅H₁₀I₄NNaO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	302.3ºC

Use of D-THYROXINE SODIUM SALT

D-thyroxine (sodium) (D-T4 (sodium)) is a laevorotatory isomer of thyroxine, and can used for the research of the dysfunctions of thyroid[1][2].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	d-thyroxine sodium salt
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	D-thyroxine (sodium) (D-T4 (sodium)) is a laevorotatory isomer of thyroxine, and can used for the research of the dysfunctions of thyroid[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
In Vitro	D-thyroxine (sodium) (D-T4 (sodium)) also influences the pharmacologic effect of bishydroxycoumarin[2].
In Vivo	D-thyroxine (sodium) (D-T4 (sodium)) inhibits the metabolism of bishydroxycoumarin as well as that of meperidine and pentobarbital in mice[1].
References	[1]. John J. Schrogie M.D., et al. II. The effect of D-thyroxine, clofibrate, and norethandrolone. Clinical Pharmacology and Therapeutics, Volume8, Issue1part1 January 1967 Pages 70-77 [2]. Raluca-IoanaStefan, et al. Simultaneous determination of l-thyroxine (l-T4), d-thyroxine (d-T4), and l-triiodothyronine (l-T3) using a sensors/sequential injection analysis system.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Boiling Point	576.3ºC at 760mmHg
Molecular Formula	C₁₅H₁₀I₄NNaO₄
Molecular Weight	798.85200
Flash Point	302.3ºC
Exact Mass	798.66900
PSA	95.61000
LogP	3.92290
Vapour Pressure	4.02E-14mmHg at 25°C
InChIKey	YDTFRJLNMPSCFM-UTONKHPSSA-M
SMILES	NC(Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)[O-].[Na+]

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XP3582990

CHEMICAL NAME :: Thyroxine, monosodium salt, D-

CAS REGISTRY NUMBER :: 137-53-1

LAST UPDATED :: 199709

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C15-H10-I4-N-O4.Na

MOLECULAR WEIGHT :: 798.85

WISWESSER LINE NOTATION :: QR BI FI DOR BI FI D1YZVO &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 12 ug/kg/12D-I

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), diffuse Liver - liver function tests impaired Nutritional and Gross Metabolic - body temperature increase

REFERENCE :: JJMDAT Japanese Journal of Medicine. (Nankodo Co., Ltd., POB 5272, Tokyo International 100-31, Japan) V.1-30, 1962-1991. For publisher information, see IEDIEP. Volume(issue)/page/year: 23,282,1984 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg/30D-C

TOXIC EFFECTS :: Vascular - BP elevation not characterized in autonomic section Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 29,207,1970

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 222 mg/kg/24W-C

TOXIC EFFECTS :: Vascular - BP elevation not characterized in autonomic section Kidney, Ureter, Bladder - changes in bladder weight Endocrine - evidence of thyroid hyperfunction

REFERENCE :: TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 29,565,1970 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 29 mg/kg

SEX/DURATION :: female 1-29 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 32,1182,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 15 mg/kg

SEX/DURATION :: female 15-29 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - physical

REFERENCE :: DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 32,1182,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 16 mg/kg

SEX/DURATION :: female 16-31 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

REFERENCE :: SDMEAL South Dakota Journal of Medicine. (South Dakota Medical Assoc., 608 West Ave. N, Sioux Falls, SD 57104) V.18- 1965- Volume(issue)/page/year: 21,33,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5407 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 63 (estimated) No. of Female Employees: 9 (estimated)

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell...
Source: ChEMBL
Target: Bile salt export pump
External Id: CHEMBL4017550

Total 1, Current Page 1 of 1

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

detyroxin

biotirmone

Travenon

EINECS 205-301-2

dextroxin

lisolipin

choloxin

dextroid

dynothel

Eulipos

dethyrona

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the molecular formula of d-thyroxine sodium salt?

A: Molecular formula of d-thyroxine sodium salt is C15H10I4NNaO4.

Q: What are the uses of d-thyroxine sodium salt?

A: Main uses of d-thyroxine sodium salt: D-thyroxine (sodium) (D-T4 (sodium)) is a laevorotatory isomer of thyroxine, and can used for the research of the dysfunctions of thyroid[1][2].

Q: What is the polar surface area (PSA) of d-thyroxine sodium salt?

A: Polar surface area (PSA) of d-thyroxine sodium salt is 95.61000.

Q: What is the English name of d-thyroxine sodium salt?

A: The English name of d-thyroxine sodium salt is d-thyroxine sodium salt.

Q: What is the LogP of d-thyroxine sodium salt?

A: LogP of d-thyroxine sodium salt is 3.92290.

Q: What is the InChIKey of d-thyroxine sodium salt?

A: InChIKey of d-thyroxine sodium salt is YDTFRJLNMPSCFM-UTONKHPSSA-M.

Q: What is the CAS number of d-thyroxine sodium salt?

A: CAS number of d-thyroxine sodium salt is 137-53-1.

Q: What is the boiling point of d-thyroxine sodium salt?

A: Boiling point of d-thyroxine sodium salt is 576.3ºC at 760mmHg.

Q: What English synonyms does d-thyroxine sodium salt have?

A: English synonyms of d-thyroxine sodium salt: detyroxin, biotirmone, Travenon, EINECS 205-301-2, dextroxin, lisolipin, choloxin, dextroid, dynothel, Eulipos, dethyrona.

Q: What is the SMILES notation of d-thyroxine sodium salt?

A: SMILES notation of d-thyroxine sodium salt is NC(Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)[O-].[Na+].

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Dextrothyroxine sodium
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
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