137-53-1

137-53-1 structure

Name: D-THYROXINE SODIUM SALT
Chemical Name: d-thyroxine sodium salt
CAS Number: 137-53-1
Molecular Formula: C₁₅H₁₀I₄NNaO₄
Molecular Weight: 798.85200
Catalog: API Hormone and endocrine-regulating drugs Thyroid hormone and antithyroid drugs
Create Date: 2018-02-24 08:00:00
Modify Date: 2026-07-01 18:32:55
D-thyroxine (sodium) (D-T4 (sodium)) is a laevorotatory isomer of thyroxine, and can used for the research of the dysfunctions of thyroid[1][2].

Name	d-thyroxine sodium salt
Synonyms	sodiumd-thyroxine D-Thyroxine monosodium salt Sodium D-3,3',5,5'-tetraiodothyronine Travenon D-3,5-DIIODO-4-(3',5'-DIIODO-4'-HYDROXYPHENOXY)-PHENYLALANINE SODIUM SALT D-Thyroxine sodium dextroxin 3:5:3’:5’-tetraiodo-d-thyroninesodium O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-D-tyrosine sodium salt lisolipin d-t4sodium D-3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]ALANINE SODIUM SALT nadrothyrond Thyroxine, monosodium salt, D- (8CI) sodiumd-t4 detyroxin D-Thyroxine monosodium salt //BP biotirmone dextrothyroxinesodium EINECS 205-301-2 monosodiumsalt,d-thyroxin D-Tyrosine,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt (1:1) sodiumdextrothyroxine Sodium-L-thyroxine 5Ho D-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, monosodium salt (9CI) dethyrona o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-d-tyrosinmonosodiumsalt (R)-2-Amino-3-[3,5-diiodo-4-(3,5-diiodo-4-hydroxyphenoxy)phenyl]propionic acid sodium salt D-B-[(3,5-DIIODO-4-HYDROXYPHENOXY)-3,5-DIIODOPHENYL]ALANINE SODIUM SALT Sodium d-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]alanine choloxin dextroid dynothel Eulipos

Description	D-thyroxine (sodium) (D-T4 (sodium)) is a laevorotatory isomer of thyroxine, and can used for the research of the dysfunctions of thyroid[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
In Vitro	D-thyroxine (sodium) (D-T4 (sodium)) also influences the pharmacologic effect of bishydroxycoumarin[2].
In Vivo	D-thyroxine (sodium) (D-T4 (sodium)) inhibits the metabolism of bishydroxycoumarin as well as that of meperidine and pentobarbital in mice[1].
References	[1]. John J. Schrogie M.D., et al. II. The effect of D-thyroxine, clofibrate, and norethandrolone. Clinical Pharmacology and Therapeutics, Volume8, Issue1part1 January 1967 Pages 70-77 [2]. Raluca-IoanaStefan, et al. Simultaneous determination of l-thyroxine (l-T4), d-thyroxine (d-T4), and l-triiodothyronine (l-T3) using a sensors/sequential injection analysis system.

Boiling Point	576.3ºC at 760mmHg
Molecular Formula	C₁₅H₁₀I₄NNaO₄
Molecular Weight	798.85200
Flash Point	302.3ºC
Exact Mass	798.66900
PSA	95.61000
LogP	3.92290
Vapour Pressure	4.02E-14mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XP3582990

CHEMICAL NAME :: Thyroxine, monosodium salt, D-

CAS REGISTRY NUMBER :: 137-53-1

LAST UPDATED :: 199709

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C15-H10-I4-N-O4.Na

MOLECULAR WEIGHT :: 798.85

WISWESSER LINE NOTATION :: QR BI FI DOR BI FI D1YZVO &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 12 ug/kg/12D-I

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), diffuse Liver - liver function tests impaired Nutritional and Gross Metabolic - body temperature increase

REFERENCE :: JJMDAT Japanese Journal of Medicine. (Nankodo Co., Ltd., POB 5272, Tokyo International 100-31, Japan) V.1-30, 1962-1991. For publisher information, see IEDIEP. Volume(issue)/page/year: 23,282,1984 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg/30D-C

TOXIC EFFECTS :: Vascular - BP elevation not characterized in autonomic section Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 29,207,1970

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 222 mg/kg/24W-C

TOXIC EFFECTS :: Vascular - BP elevation not characterized in autonomic section Kidney, Ureter, Bladder - changes in bladder weight Endocrine - evidence of thyroid hyperfunction

REFERENCE :: TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 29,565,1970 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 29 mg/kg

SEX/DURATION :: female 1-29 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 32,1182,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 15 mg/kg

SEX/DURATION :: female 15-29 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - physical

REFERENCE :: DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 32,1182,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 16 mg/kg

SEX/DURATION :: female 16-31 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

REFERENCE :: SDMEAL South Dakota Journal of Medicine. (South Dakota Medical Assoc., 608 West Ave. N, Sioux Falls, SD 57104) V.18- 1965- Volume(issue)/page/year: 21,33,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5407 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 63 (estimated) No. of Female Employees: 9 (estimated)

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