13925-12-7

• 常用中文名：1-Phenazinol,6-methoxy-, 5,10-dioxide
• 常用英文名：1-Phenazinol,6-methoxy-, 5,10-dioxide
• CAS号：13925-12-7
• 分子式：C₁₃H₁₀N₂O₄
• 分子量：258.23000
• 相关类别： 研究领域 癌症
• 发布时间：2016-12-19 07:08:49
• 更新时间：2024-01-10 15:25:22
• 粘菌素是一种由抗微生物溶杆菌OH13产生的二氮氧化物吩嗪。粘菌素对许多微生物和肿瘤细胞有毒[1]。

名称

• 英文名: 5-hydroxy-6-methoxy-10-oxidophenazin-10-ium-1-one
• 英文别名: Myxin; 6-Methoxy-1-phenazinol 5,10-dioxide; 1-Hydroxy-6-methoxyphenazine 5,10-dioxide; 1-hydroxy-6-methoxyphenazine N5,N10-dioxide; 3C Antibiotic; 1-Phenazinol,6-methoxy-,5,10-dioxide; 6-methoxy-5,10-dioxy-phenazin-1-ol; 1-Methoxy-6-hydroxyphenazin-5,10-dioxid

物化性质

• 密度: 1.53g/cm3
• 沸点: 538.8ºC at 760mmHg
• 分子式: C₁₃H₁₀N₂O₄
• 分子量: 258.23000
• 闪点: 279.7ºC
• 精确质量: 258.06400
• PSA: 80.38000
• LogP: 2.56420
• 蒸汽压: 1.93E-12mmHg at 25°C
• 折射率: 1.73

生物活性

• 描述: 粘菌素是一种由抗微生物溶杆菌OH13产生的二氮氧化物吩嗪。粘菌素对许多微生物和肿瘤细胞有毒[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Liu J, et al. Monooxygenase LaPhzX is Involved in Self-Resistance Mechanisms during the Biosynthesis of N-Oxide Phenazine Myxin. J Agric Food Chem. 2021;69(45):13524-13532.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SG1660000 CHEMICAL NAME : 1-Phenazinol, 6-methoxy-, 5,10-dioxide CAS REGISTRY NUMBER : 13925-12-7 BEILSTEIN REFERENCE NO. : 0622031 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C13-H10-N2-O4 MOLECULAR WEIGHT : 258.25 WISWESSER LINE NOTATION : T C666 BN INJ BO DQ IO KO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 133 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Protozoa - Euglena gracilis DOSE/DURATION : 10 mg/L REFERENCE : EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 27,586,1971

安全

• 海关编码: 2933990090

合成路线

13129-58-3 ~7% 13129-57-2 13925-12-7

文献：Chowdhury, Goutam; Sarkar, Ujjal; Pullen, Susan; Wilson, William R.; Rajapakse, Anuruddha; Fuchs-Knotts, Tarra; Gates, Kent S. Chemical Research in Toxicology, 2012 , vol. 25, # 1 p. 197 - 206

91-23-6 ~% 13925-12-7

文献：Chowdhury, Goutam; Sarkar, Ujjal; Pullen, Susan; Wilson, William R.; Rajapakse, Anuruddha; Fuchs-Knotts, Tarra; Gates, Kent S. Chemical Research in Toxicology, 2012 , vol. 25, # 1 p. 197 - 206

13398-79-3 ~% 13925-12-7

文献：Chowdhury, Goutam; Sarkar, Ujjal; Pullen, Susan; Wilson, William R.; Rajapakse, Anuruddha; Fuchs-Knotts, Tarra; Gates, Kent S. Chemical Research in Toxicology, 2012 , vol. 25, # 1 p. 197 - 206

90-04-0 ~% 13925-12-7

文献：Chowdhury, Goutam; Sarkar, Ujjal; Pullen, Susan; Wilson, William R.; Rajapakse, Anuruddha; Fuchs-Knotts, Tarra; Gates, Kent S. Chemical Research in Toxicology, 2012 , vol. 25, # 1 p. 197 - 206

上下游产品

上游产品  4
13129-58-3 91-23-6 13398-79-3 90-04-0
下游产品  1
13129-57-2

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%