55303-98-5

• 常用中文名：Avarol
• 常用英文名：Avarol
• CAS号：55303-98-5
• 分子式：C₂₁H₃₀O₂
• 分子量：314.46200
• 发布时间：2017-09-07 23:27:23
• 更新时间：2024-01-06 15:47:56
• Avarol induces apoptosis in pancreatic ductal adenocarcinoma cells by activating PERK-eIF2α-CHOP signaling. Avarl also acts as a competitive AChE inhibitor which are non-hepatotoxic and neuroprotective agents for Alzheimer's disease.

名称

• 英文名: 2-[[(1R,2S,4aS,8aS)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]methyl]benzene-1,4-diol
• 英文别名: Avarol; 2-{[(1r,2s,4as,8as)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]methyl}benzene-1,4-diol; (1R-(1alpha,2beta,4abeta,8abeta))-2-((1,2,3,4,4a,7,8,8a-Octahydro-1,2,4a,5-tetramethyl-1-naphthalenyl)methyl)-1,4-benzenediol; Avrol

物化性质

• 密度: 1.055g/cm3
• 沸点: 449.5ºC at 760 mmHg
• 分子式: C₂₁H₃₀O₂
• 分子量: 314.46200
• 闪点: 200ºC
• 精确质量: 314.22500
• PSA: 40.46000
• LogP: 5.43910
• 折射率: 1.552

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : CZ9026700 CHEMICAL NAME : 1,4-Benzenediol, 2-((1,2,3,4,4a,7,8,8a-octahydro-1,2,4a,5-tetramethyl- 1-naphthalenyl) methyl)-, (1R-(1-alpha,2-beta,4a-beta,8a-alpha))- CAS REGISTRY NUMBER : 55303-98-5 LAST UPDATED : 199406 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C21-H30-O2 MOLECULAR WEIGHT : 314.51 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 269 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Cells - not otherwise specified DOSE/DURATION : 3800 nmol/L REFERENCE : EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)- 25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year: 22,473,1986

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