31828-71-4

• 常用中文名：美西律
• 常用英文名：1-(2,6-Dimethylphenoxy)-2-propanamine
• CAS号：31828-71-4
• 分子式：C₁₁H₁₇NO
• 分子量：179.25900
• 相关类别： 原料药 循环系统用药 抗心律失常药
• 发布时间：2018-09-14 17:41:59
• 更新时间：2026-07-23 13:38:20
• 【用途一】
  用作抗心律失常药。

名称

• 中文名: 美西律
• 英文名: mexiletine
• 中文别名: 慢心律,美西律,慢心利,脉律定, 1-(2,6-二甲基苯氧基)-2-丙胺; 1-(2,6-二甲基苯氧基)丙-2-胺; 1-(2,6-二甲基苯氧基)-2-丙胺; 慢心利; 慢心律; 美西律对照品; 脉律定; 美西律标准品
• 英文别名: (R)-1-Methyl-2-(2,6-xylyloxy)ethylamine; Ko 1173Cl; (RS)-Mexiletine; mexitil; Cirumimeru; dl-Mexiletine; Mexilitine R; (2R)-1-(2,6-Dimethylphenoxy)propane-2-amine; Mexilitine; 1-methyl-2-(2,6-xylyloxy)-ethylamin; Mexiletine - API; Mexilitene; Ethylamine, 1-methyl-2-(2,6-xylyloxy)- (8CI); Olzoron; MEXILITINE HCL; Mexilux; 2-Amino-1-(2,6-dimethylphenoxy)propane; EINECS 250-825-7; Mexiletene; ko1173; Katen; MFCD00216024; (+-)-2-Amino-1-(2',6'-dimethylphenoxy)propane; Mexiletine; 1-(2,6-xylyloxy)-2-aminopropane hydrochloride; 1-(2,6-Dimethylphenoxy)-2-propanamine //BP; Mexiletine (base and/or unspecified salts); Ritalmex; 2-Propanamine, 1-(2,6-dimethylphenoxy); 1-(2,6-Dimethylphenoxy)propane-2-amine; C07220; 1-(2,6-dimethylphenoxy)-2-propanamin; Ethylamine, 1-methyl-2-(2,6-xylyloxy); 1-Methyl-2-(2,6-xylyloxy)ethylamine; 2-Propanamine, 1-(2,6-dimethylphenoxy)- (9CI); MEXILETIN; (S)-1-Methyl-2-(2,6-xylyloxy)ethylamine; Toy

物化性质

• 密度: 0.979 g/cm3
• 沸点: 271.5ºC at 760 mmHg
• 熔点: 203-205ºC
• 分子式: C₁₁H₁₇NO
• 分子量: 179.25900
• 闪点: 112.2ºC
• 精确质量: 179.13100
• PSA: 35.25000
• LogP: 2.72970
• 外观性状: powder | white
• 储存条件: 2-8°C
• 水溶解性: ethanol: 50 mg/mL

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KR9300000 CHEMICAL NAME : Ethylamine, 1-methyl-2-(2,6-xylyloxy)- CAS REGISTRY NUMBER : 31828-71-4 LAST UPDATED : 199703 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C11-H17-N-O MOLECULAR WEIGHT : 179.29 WISWESSER LINE NOTATION : ZY1&1OR B1 F1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 63 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis Gastrointestinal - nausea or vomiting REFERENCE : PMESAJ Postgraduate Medical Journal, Supplement. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1949- Volume(issue)/page/year: 53(Suppl 1),134,1977 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 349 mg/kg/4D-I TOXIC EFFECTS : Blood - thrombocytopenia REFERENCE : AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 100,162,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 41 mg/kg TOXIC EFFECTS : Toxic effects not yet reviewed REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #5116974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 320 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 13,21,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 114 mg/kg TOXIC EFFECTS : Cardiac - arrhythmias (including changes in conduction) REFERENCE : EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 21,370,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 23 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 41,1130,1991

安全

• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): R20/21/22
• 安全声明 (欧洲): S36
• 危险品运输编码: UN 3249
• WGK德国: 3
• RTECS号: KR9300000
• 包装等级: III
• 危险类别: 6.1(b)
• 海关编码: 2922299090

上下游产品

上游产品  8
1092493-53-2 72806-53-2 5370-01-4 53012-41-2
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下游产品  3
53012-41-2 94991-72-7 31828-71-4

制备

【方法一】
由2，6-二甲基苯酚出发。

海关

海关编码	2922299090
中文概述	2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
Summary	2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%