65267-04-1

• 常用中文名：2-[(2-chloroethyl-nitroso-carbamoyl)amino]acetamide
• 常用英文名：2-[(2-chloroethyl-nitroso-carbamoyl)amino]acetamide
• CAS号：65267-04-1
• 分子式：C₅H₉ClN₄O₃
• 分子量：208.60300
• 发布时间：2017-07-05 21:11:59
• 更新时间：2024-01-19 09:51:58

名称

• 英文名: 2-[[2-chloroethyl(nitroso)carbamoyl]amino]acetamide
• 英文别名: 1-(Carbamoylmethyl)-3-(2-chloroethyl)-3-nitrosourea; Urea,1-(carbamoylmethyl)-3-(2-chloroethyl)-3-nitroso; N-<N'-(2-chloroethyl)-N'-nitrosocarbamoyl>glycinamide; 2-(3-(2-chloroethyl))-3-nitrosoureido acetamide; n2-[(2-chloroethyl)(nitroso)carbamoyl]glycinamide

物化性质

• 密度: 1.58g/cm3
• 分子式: C₅H₉ClN₄O₃
• 分子量: 208.60300
• 精确质量: 208.03600
• PSA: 104.86000
• LogP: 0.49470
• 折射率: 1.597

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : YS4552830 CHEMICAL NAME : Urea, 1-(carbamoylmethyl)-3-(2-chloroethyl)-3-nitroso- CAS REGISTRY NUMBER : 65267-04-1 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C5-H9-Cl-N4-O3 MOLECULAR WEIGHT : 208.63 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 21230 ug/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 25,829,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 22400 ug/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 25,829,1982

合成路线

60784-40-9 1668-10-6 ~40% 65267-04-1

文献：Eisenbrand; Gerhard Patent: US4150146 A1, 1979 ;

55661-43-3 598-41-4 ~73% 65267-04-1

文献：Suami; Kato; Takino; Hisamatsu Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 829 - 832

80354-49-0 598-41-4 ~51% 65267-04-1

文献：Sosnovsky; Gnewuch Journal of Pharmaceutical Sciences, 1994 , vol. 83, # 7 p. 989 - 998

上下游产品

上游产品  4
1668-10-6 55661-43-3 598-41-4 80354-49-0
下游产品  0