7306-46-9

• 常用中文名：3,4-二甲氧基苄氯
• 常用英文名：3,4-Dimethoxybenzyl chloride
• CAS号：7306-46-9
• 分子式：C₉H₁₁ClO₂
• 分子量：186.635
• 发布时间：2018-09-25 17:08:12
• 更新时间：2024-01-05 23:11:43
• 【用途一】
  四氢巴马丁（延胡索乙素）的中间体。

名称

• 中文名: 3,4-二甲氧基苄氯
• 英文名: 4-(chloromethyl)-1,2-dimethoxybenzene
• 中文别名: 1-氯甲基-3,4-二甲氧基苯; 3,4-二甲氧基氯化苄
• 英文别名: 3,4-Dimethoxybenzyl chloride; Benzene, 4-(chloromethyl)-1,2-dimethoxy-; Veratryl chloride; EINECS 230-756-9; 3,4-dimethoxy-benzyl-chloride; 4-(Chloromethyl)-1,2-dimethoxybenzene; MFCD00185554; 1,2-dimethoxy-4-chloromethyl-benzene

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 260.8±25.0 °C at 760 mmHg
• 熔点: 50-53ºC(lit.)
• 分子式: C₉H₁₁ClO₂
• 分子量: 186.635
• 闪点: 98.6±18.4 °C
• 精确质量: 186.044754
• PSA: 18.46000
• LogP: 2.22
• 外观性状: 白色结晶粉末
• 蒸汽压: 0.0±0.5 mmHg at 25°C
• 折射率: 1.510
• 储存条件: 库房通风低温干燥

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: 3,4-Dimethoxybenzyl chloride Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:3,4-Dimethoxybenzyl chloride CAS number:7306-46-9 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels, refrigerated. Storage: Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data No data Melting point: Flash point:No data Density:No data Molecular formula:C9H11ClO2 Molecular weight:186.6 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, hydrogen chloride. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : XS9060000 CHEMICAL NAME : Toluene, alpha-chloro-3,4-dimethoxy- CAS REGISTRY NUMBER : 7306-46-9 BEILSTEIN REFERENCE NO. : 0973727 LAST UPDATED : 199707 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C9-H11-Cl-O2 MOLECULAR WEIGHT : 186.65 WISWESSER LINE NOTATION : G1R CO1 DO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4700 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) REFERENCE : GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 26(2),55,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7. Volume(issue)/page/year: 74,241,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5 gm/kg TOXIC EFFECTS : Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) REFERENCE : GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 26(2),55,1982 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2100 mg/kg/42W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application REFERENCE : ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7. Volume(issue)/page/year: 74,241,1970

安全

• 危害码 (欧洲): C: Corrosive;
• 风险声明 (欧洲): R34
• 安全声明 (欧洲): 26-36/37/39-45
• 危险品运输编码: UN 1759 8/PG 2
• RTECS号: XS9060000
• 海关编码: 2909309090

合成路线

上下游产品

上游产品  10
93-03-8 93-07-2 108-48-5 5653-67-8
91-16-7 120-14-9 107-30-2 52602-38-7
50-00-0 6378-11-6
下游产品  10
32161-30-1 33605-56-0 91-16-7 494-99-5
100-66-3 50896-90-7 4747-98-2 120-14-9
725-12-2 93-40-3

制备

【方法一】
用愈创木酚经甲基化（醚化）、氯甲基化制得。

海关

海关编码	2909309090
中文概述	2909309090 其他芳香醚及其卤化衍生物、磺化、硝化衍生物（包括亚硝化衍生物）。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%