149003-01-0

• 常用中文名：右雷佐生盐酸盐
• 常用英文名：Dexrazoxane HCl (ICRF-187, ADR-529)
• CAS号：149003-01-0
• 分子式：C₁₁H₁₇ClN₄O₄
• 分子量：304.73000
• 相关类别： 研究领域 心血管疾病
• 发布时间：2018-07-11 18:13:39
• 更新时间：2024-01-05 20:56:11
• Dexrazoxane( ICRF-187)盐酸盐是心脏保护剂。

名称

• 中文名: 右雷佐生盐酸盐
• 英文名: dexrazoxane hydrochloride
• 中文别名: 右丙亚胺盐酸盐; 盐酸右雷佐生
• 英文别名: 2,6-Piperazinedione, 4-[(1S)-2-(3,5-dioxo-1-piperazinyl)-1-methylethyl]-, hydrochloride (1:1); 4,4'-(2S)-Propan-1,2-diyldipiperazin-2,6-dionhydrochlorid; 4,4'-(2S)-propane-1,2-diyldipipérazine-2,6-dione chlorhydrate; (S)-4,4'-(1-Methyl-1,2-ethanediyl)bis-2,6-piperazinedionehydrochloride; Dexrazoxane hydrochloride; 2,6-Piperazinedione, 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-, hydrochloride (1:1); 4,4'-[(2S)-1,2-Propanediyl]di(2,6-piperazinedione) hydrochloride (1:1); 2,6-piperazinedione, 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-, monohydrochloride; 4,4'-(2S)-Propane-1,2-diyldipiperazine-2,6-dione hydrochloride (1:1); Dexrazoxane HCl; UNII:5346058Q7S; Dexrazoxane (Hydrochloride)

物化性质

• 沸点: 531.5ºC at 760 mmHg
• 熔点: 193ºC
• 分子式: C₁₁H₁₇ClN₄O₄
• 分子量: 304.73000
• 闪点: 275.3ºC
• 精确质量: 304.09400
• PSA: 98.82000
• 蒸汽压: 2.22E-11mmHg at 25°C
• 储存条件: -20°C

生物活性

• 描述: Dexrazoxane( ICRF-187)盐酸盐是心脏保护剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Hasinoff BB. The use of dexrazoxane for the prevention of anthracycline extravasation injury. Expert Opin Investig Drugs. 2008 Feb;17(2):217-23.

  [2]. Jones RL. Utility of dexrazoxane for the reduction of anthracycline-induced cardiotoxicity. Expert Rev Cardiovasc Ther. 2008 Nov;6(10):1311-7.

  [3]. Lipshultz SE, Scully RE, Lipsitz SR et al. Assessment of dexrazoxane as a cardioprotectant in doxorubicin-treated children with high-risk acute lymphoblastic leukaemia: long-term follow-up of a prospective, randomised, multicentre trial. Lancet Oncol. 201

安全

• 危害码 (欧洲): Xi